Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O76942

- PTP1_ENCCU

UniProt

O76942 - PTP1_ENCCU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polar tube protein 1

Gene

PTP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.

GO - Biological processi

  1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name:
Major PTP
Gene namesi
Name:PTP1
Ordered Locus Names:ECU06_0250
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0250.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 395373Polar tube protein 1PRO_0000022181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Found in spores. Expression is high during polar tube formation.1 Publication

Interactioni

Subunit structurei

Interacts with PTP2 and PTP3.1 Publication

Protein-protein interaction databases

STRINGi6035.ECU06_0250.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati179 – 204261Add
BLAST
Repeati205 – 230262Add
BLAST
Repeati231 – 256263Add
BLAST
Repeati257 – 282264Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 2821044 X 26 AA approximate tandem repeatsAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000115778.
OMAiTLCQGQA.
OrthoDBiEOG7K0ZQ5.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76942-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGISKILSA SIALMKLENV YSATALCSNA YGLTPGQQGM AQQPSYVLIP
60 70 80 90 100
STPGTIANCA SGSQDTYSPS PAAPTSPVTP GKTSENETSP SAPAEDVGTC
110 120 130 140 150
KIAVLKHCDA PGTTSGTTPG SGPCETPEQQ QPLSVISTTP AVPVTVESAQ
160 170 180 190 200
SPSVVPVVPV VAHHQAVPGY YNNGTSGIPG QQQILSGTLP PGATLCQGQA
210 220 230 240 250
MPSTPGQQQI LSGTLPPGVT LCQGQATPST PGQQQVLSGT LPPGVTLCQG
260 270 280 290 300
QATPSTPGQQ QVLSGTLLPG ATLCQDQGMP GTSGVPGQQG QSSGQCCAPQ
310 320 330 340 350
IPNPVMPPSM NISGNGYPSS TAYSPNLGSL GSCVDIQKTG GTSCEQKPEK
360 370 380 390
SATQYAMEAC ATPTPTVIIG NSEYLVGPGM YNAINSPCNT AVQCC
Length:395
Mass (Da):39,609
Last modified:November 1, 1998 - v1
Checksum:i8FB498209F5EA9B9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti209 – 23426Missing in strain: CDC:V282.
Add
BLAST
Natural varianti210 – 2101I → V in strain: m104.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005666 Genomic DNA. Translation: CAA06662.1.
AL590446 Genomic DNA. Translation: CAD25385.1.
AF310677 Genomic DNA. Translation: AAK62814.1.
AF310678 Genomic DNA. Translation: AAK62815.1.
AF310679 Genomic DNA. Translation: AAK62816.1.
RefSeqiNP_585781.1. NM_001041403.1.

Genome annotation databases

GeneIDi859204.
KEGGiecu:ECU06_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005666 Genomic DNA. Translation: CAA06662.1 .
AL590446 Genomic DNA. Translation: CAD25385.1 .
AF310677 Genomic DNA. Translation: AAK62814.1 .
AF310678 Genomic DNA. Translation: AAK62815.1 .
AF310679 Genomic DNA. Translation: AAK62816.1 .
RefSeqi NP_585781.1. NM_001041403.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU06_0250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859204.
KEGGi ecu:ECU06_0250.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU06_0250.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000115778.
OMAi TLCQGQA.
OrthoDBi EOG7K0ZQ5.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "On proteins of the microsporidian invasive apparatus: complete sequence of a polar tube protein of Encephalitozoon cuniculi."
    Delbac F., Peyret P., Metenier G., David D., Danchin A., Vivares C.P.
    Mol. Microbiol. 29:825-834(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42 AND 351-365, CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  3. "Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences."
    Xiao L., Li L., Visvesvara G.S., Moura H., Didier E.S., Lal A.A.
    J. Clin. Microbiol. 39:2248-2253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-349.
    Strain: CDC:V282, CDC:V385 and m104.
  4. "The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi."
    Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.
    Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTP2 AND PTP3.
  5. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPTP1_ENCCU
AccessioniPrimary (citable) accession number: O76942
Secondary accession number(s): Q964G9, Q964H0, Q964H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3