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O76942

- PTP1_ENCCU

UniProt

O76942 - PTP1_ENCCU

Protein

Polar tube protein 1

Gene

PTP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.

    GO - Biological processi

    1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Sporulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polar tube protein 1
    Alternative name(s):
    Major polar tube protein
    Short name:
    Major PTP
    Gene namesi
    Name:PTP1
    Ordered Locus Names:ECU06_0250
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VI

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU06_0250.

    Subcellular locationi

    GO - Cellular componenti

    1. polar tube Source: UniProtKB-SubCell

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 395373Polar tube protein 1PRO_0000022181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Developmental stagei

    Found in spores. Expression is high during polar tube formation.1 Publication

    Interactioni

    Subunit structurei

    Interacts with PTP2 and PTP3.1 Publication

    Protein-protein interaction databases

    STRINGi6035.ECU06_0250.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati179 – 204261Add
    BLAST
    Repeati205 – 230262Add
    BLAST
    Repeati231 – 256263Add
    BLAST
    Repeati257 – 282264Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni179 – 2821044 X 26 AA approximate tandem repeatsAdd
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000115778.
    OMAiTLCQGQA.
    OrthoDBiEOG7K0ZQ5.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O76942-1 [UniParc]FASTAAdd to Basket

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    MKGISKILSA SIALMKLENV YSATALCSNA YGLTPGQQGM AQQPSYVLIP    50
    STPGTIANCA SGSQDTYSPS PAAPTSPVTP GKTSENETSP SAPAEDVGTC 100
    KIAVLKHCDA PGTTSGTTPG SGPCETPEQQ QPLSVISTTP AVPVTVESAQ 150
    SPSVVPVVPV VAHHQAVPGY YNNGTSGIPG QQQILSGTLP PGATLCQGQA 200
    MPSTPGQQQI LSGTLPPGVT LCQGQATPST PGQQQVLSGT LPPGVTLCQG 250
    QATPSTPGQQ QVLSGTLLPG ATLCQDQGMP GTSGVPGQQG QSSGQCCAPQ 300
    IPNPVMPPSM NISGNGYPSS TAYSPNLGSL GSCVDIQKTG GTSCEQKPEK 350
    SATQYAMEAC ATPTPTVIIG NSEYLVGPGM YNAINSPCNT AVQCC 395
    Length:395
    Mass (Da):39,609
    Last modified:November 1, 1998 - v1
    Checksum:i8FB498209F5EA9B9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti209 – 23426Missing in strain: CDC:V282.
    Add
    BLAST
    Natural varianti210 – 2101I → V in strain: m104.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005666 Genomic DNA. Translation: CAA06662.1.
    AL590446 Genomic DNA. Translation: CAD25385.1.
    AF310677 Genomic DNA. Translation: AAK62814.1.
    AF310678 Genomic DNA. Translation: AAK62815.1.
    AF310679 Genomic DNA. Translation: AAK62816.1.
    RefSeqiNP_585781.1. NM_001041403.1.

    Genome annotation databases

    GeneIDi859204.
    KEGGiecu:ECU06_0250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005666 Genomic DNA. Translation: CAA06662.1 .
    AL590446 Genomic DNA. Translation: CAD25385.1 .
    AF310677 Genomic DNA. Translation: AAK62814.1 .
    AF310678 Genomic DNA. Translation: AAK62815.1 .
    AF310679 Genomic DNA. Translation: AAK62816.1 .
    RefSeqi NP_585781.1. NM_001041403.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU06_0250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859204.
    KEGGi ecu:ECU06_0250.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU06_0250.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000115778.
    OMAi TLCQGQA.
    OrthoDBi EOG7K0ZQ5.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "On proteins of the microsporidian invasive apparatus: complete sequence of a polar tube protein of Encephalitozoon cuniculi."
      Delbac F., Peyret P., Metenier G., David D., Danchin A., Vivares C.P.
      Mol. Microbiol. 29:825-834(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42 AND 351-365, CHARACTERIZATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    3. "Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences."
      Xiao L., Li L., Visvesvara G.S., Moura H., Didier E.S., Lal A.A.
      J. Clin. Microbiol. 39:2248-2253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-349.
      Strain: CDC:V282, CDC:V385 and m104.
    4. "The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi."
      Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.
      Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTP2 AND PTP3.
    5. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPTP1_ENCCU
    AccessioniPrimary (citable) accession number: O76942
    Secondary accession number(s): Q964G9, Q964H0, Q964H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3