Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O76942 (PTP1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name=Major PTP
Gene names
Name:PTP1
Ordered Locus Names:ECU06_0250
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.

Subunit structure

Interacts with PTP2 and PTP3. Ref.4

Subcellular location

Spore polar tube.

Developmental stage

Found in spores. Expression is high during polar tube formation.

Ontologies

Keywords
   Biological processSporulation
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processsporulation resulting in formation of a cellular spore

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentpolar tube

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Chain23 – 395373Polar tube protein 1
PRO_0000022181

Regions

Repeat179 – 204261
Repeat205 – 230262
Repeat231 – 256263
Repeat257 – 282264
Region179 – 2821044 X 26 AA approximate tandem repeats

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential

Natural variations

Natural variant209 – 23426Missing in strain: CDC:V282.
Natural variant2101I → V in strain: m104.

Sequences

Sequence LengthMass (Da)Tools
O76942 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8FB498209F5EA9B9

FASTA39539,609
        10         20         30         40         50         60 
MKGISKILSA SIALMKLENV YSATALCSNA YGLTPGQQGM AQQPSYVLIP STPGTIANCA 

        70         80         90        100        110        120 
SGSQDTYSPS PAAPTSPVTP GKTSENETSP SAPAEDVGTC KIAVLKHCDA PGTTSGTTPG 

       130        140        150        160        170        180 
SGPCETPEQQ QPLSVISTTP AVPVTVESAQ SPSVVPVVPV VAHHQAVPGY YNNGTSGIPG 

       190        200        210        220        230        240 
QQQILSGTLP PGATLCQGQA MPSTPGQQQI LSGTLPPGVT LCQGQATPST PGQQQVLSGT 

       250        260        270        280        290        300 
LPPGVTLCQG QATPSTPGQQ QVLSGTLLPG ATLCQDQGMP GTSGVPGQQG QSSGQCCAPQ 

       310        320        330        340        350        360 
IPNPVMPPSM NISGNGYPSS TAYSPNLGSL GSCVDIQKTG GTSCEQKPEK SATQYAMEAC 

       370        380        390 
ATPTPTVIIG NSEYLVGPGM YNAINSPCNT AVQCC 

« Hide

References

« Hide 'large scale' references
[1]"On proteins of the microsporidian invasive apparatus: complete sequence of a polar tube protein of Encephalitozoon cuniculi."
Delbac F., Peyret P., Metenier G., David D., Danchin A., Vivares C.P.
Mol. Microbiol. 29:825-834(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42 AND 351-365, CHARACTERIZATION.
[2]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[3]"Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences."
Xiao L., Li L., Visvesvara G.S., Moura H., Didier E.S., Lal A.A.
J. Clin. Microbiol. 39:2248-2253(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-349.
Strain: CDC:V282, CDC:V385 and m104.
[4]"The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi."
Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.
Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PTP2 AND PTP3.
[5]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ005666 Genomic DNA. Translation: CAA06662.1.
AL590446 Genomic DNA. Translation: CAD25385.1.
AF310677 Genomic DNA. Translation: AAK62814.1.
AF310678 Genomic DNA. Translation: AAK62815.1.
AF310679 Genomic DNA. Translation: AAK62816.1.
RefSeqNP_585781.1. NM_001041403.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU06_0250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859204.
KEGGecu:ECU06_0250.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU06_0250.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000115778.
OMATLCQGQA.
OrthoDBEOG7K0ZQ5.

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePTP1_ENCCU
AccessionPrimary (citable) accession number: O76942
Secondary accession number(s): Q964G9, Q964H0, Q964H1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program