ID   O76937_GIRTI            Unreviewed;       259 AA.
AC   O76937;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=Homeodomain protein {ECO:0000313|EMBL:CAA64696.1};
GN   Name=DthoxC {ECO:0000313|EMBL:CAA64696.1};
OS   Girardia tigrina (Planarian) (Dugesia tigrina).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Girardia.
OX   NCBI_TaxID=6162 {ECO:0000313|EMBL:CAA64696.1};
RN   [1] {ECO:0000313|EMBL:CAA64696.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9006075;
RA   Bayascas J.R., Castillo E., Munoz-Marmol A.M., Salo E.;
RT   "Planarian Hox genes: novel patterns of expression during regeneration.";
RL   Development 124:141-148(1997).
RN   [2] {ECO:0000313|EMBL:CAA64696.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9799427; DOI=10.1007/s004270050204;
RA   Bayascas J.R., Castillo E., Salo E.;
RT   "Platyhelminthes have a hox code differentially activated during
RT   regeneration, with genes closely related to those of spiralian
RT   protostomes.";
RL   Dev. Genes Evol. 208:467-473(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR   EMBL; X95416; CAA64696.1; -; Genomic_DNA.
DR   AlphaFoldDB; O76937; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659:SF21; HOMEOBOX PROTEIN ABDOMINAL-A-RELATED; 1.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}.
FT   DOMAIN          171..231
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  29892 MW;  C1D022B1EEFED25D CRC64;
     MHVDPNVPNP LQNSPSKLLS SKSSNHLPLS NLSKSSQIPA IGRYWPASIS KVSSSEHFGS
     LIATNFYSNS KVFPNSPWST HFPANDLAFD SSVFDSRRPH EESYLNAVPH FSSSQFSPYS
     QTCRQLIYPS ISTYESSESK ISDININPVS NNVMLYSWMN PKSSGDNTNN TNNKRTRQTY
     TRHQTLELEK EFHFNKYLTR RRRIEIAHTL ILTERQIKIW FQNRRMKWKK EHNIAKLTGP
     GSCDQLELVK TYNISQQYN
//