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Protein

Aconitate hydratase

Gene

Irp-1B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.UniRule annotation

Catalytic activityi

Citrate = isocitrate.UniRule annotation

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • aconitate hydratase activity Source: FlyBase
  • iron ion binding Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydrataseUniRule annotation (EC:4.2.1.3UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Name:Irp-1BImported
Synonyms:IRP-1BImported
ORF Names:CG6342Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0024957. Irp-1B.

PTM / Processingi

Proteomic databases

PaxDbiO76935.
PRIDEiO76935.

Expressioni

Gene expression databases

BgeeiO76935.
ExpressionAtlasiO76935. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0081736.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 574496AconitaseInterPro annotationAdd
BLAST
Domaini703 – 828126Aconitase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0452. Eukaryota.
COG1048. LUCA.
OrthoDBiEOG7CG6Z7.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 4 hits.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGANPFAQF EKTFSQAGTT YKYFDLASID SKYDQLPYSI RVLLESAVRN
60 70 80 90 100
CDNFHILEKD VQSILGWSPA LKQGSNDVEV SFKPARVILQ DFTGVPAVVD
110 120 130 140 150
FAAMRDAVLD LGGDPEKINP ICPADLVIDH SVQVDFARAP DALAKNQSLE
160 170 180 190 200
FERNKERFTF LKWGAKAFNN MLIVPPGSGI VHQVNLEYLA RVVFENDATD
210 220 230 240 250
GSKILYPDSV VGTDSHTTMI NGLGVLGWGV GGIEAEAVML GQSISMLLPE
260 270 280 290 300
VIGYKLEGKL SPLVTTTDLV LTITKHLRQL GVVGKFVEFY GPGVAELSIA
310 320 330 340 350
DRATISNMCP EYGATVGYFP IDENTLGYMK QTNRSEKKID IIRQYLKATQ
360 370 380 390 400
QLRNYADAAQ DPKFTQSITL DLSTVVTSVS GPKRPHDRVS VSDMPEDFKS
410 420 430 440 450
CLSSPVGFKG FAIAPEAQSA FGEFQWDDGK TYKLHHGSVV IAAITSCTNT
460 470 480 490 500
SNPSVMLGAG LLAKKAVEKG LSILPYIKTS LSPGSGVVTY YLKESGVIPY
510 520 530 540 550
LEKLGFDIVG YGCMTCIGNS GPLEENVVTQ SKKTGLVCAR VLSGNRNFEG
560 570 580 590 600
RIHPNTRANY LASPLLVIAY AIAGRVDIDF EKEPLGVDAN GKNVFLQDIW
610 620 630 640 650
PTRSEIQEVE NKHVIPAMFQ EVYSKIELGS QDWQTLQVSE GKLFSWSADS
660 670 680 690 700
TYIKRPPFFE GMTRDLPKLQ SIQKARCLLF LGDXVTTDHI SPAGSIAXTS
710 720 730 740 750
PAARFLSERN ITPRDFNSYG SRRGNDAIMS RGTFANIRLV NKLVEKTGPP
760 770 780 790 800
TVHIPSQEEL DIFDAAERYR EEGTPLVLVV GKDYGSGSSR DWAAKGPFLL
810 820 830 840 850
GVKAVIAESY ERIHRSNMVG MGIIPXQFLP GQSAETLNLT GREVYNIALP
860 870 880 890
ESGLKPGQKI QVEADGTVFE TILRFDTEVD ITYYKNGGIL NYMIRKMLS
Length:899
Mass (Da):98,602
Last modified:November 1, 1998 - v1
Checksum:iCDF68AA1D8036B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223248 mRNA. Translation: CAA11212.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223248 mRNA. Translation: CAA11212.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0081736.

Proteomic databases

PaxDbiO76935.
PRIDEiO76935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0024957. Irp-1B.

Phylogenomic databases

eggNOGiKOG0452. Eukaryota.
COG1048. LUCA.
OrthoDBiEOG7CG6Z7.

Gene expression databases

BgeeiO76935.
ExpressionAtlasiO76935. differential.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 4 hits.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans."
    Muckenthaler M., Gunkel N., Frishman D., Cyrklaff A., Tomancak P., Hentze M.W.
    Eur. J. Biochem. 254:230-237(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Whole flyImported.
  2. Muckenthaler M.U.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Whole flyImported.

Entry informationi

Entry nameiO76935_DROME
AccessioniPrimary (citable) accession number: O76935
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.