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Protein

40S ribosomal protein S21

Gene

RpS21

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva.1 Publication

GO - Molecular functioni

  • ribosome binding Source: UniProtKB
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein
Biological processrRNA processing, Translation regulation

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S211 PublicationImported
Alternative name(s):
Overgrown hematopoietic organs at 23BImported
Gene namesi
Name:RpS21
Synonyms:oho23B
ORF Names:CG2986
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0015521 RpS21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954181 – 8340S ribosomal protein S21Add BLAST83

Proteomic databases

PaxDbiO76927
PRIDEiO76927

Expressioni

Developmental stagei

Uniformly expressed at all developmental stages.1 Publication

Gene expression databases

BgeeiFBgn0015521
ExpressionAtlasiO76927 baseline and differential
GenevisibleiO76927 DM

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit (PubMed:23636399). Interacts with sta (PubMed:10022917).2 Publications

Protein-protein interaction databases

BioGridi59710, 52 interactors
IntActiO76927, 1 interactor
STRINGi7227.FBpp0077309

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AV1-83[»]
ProteinModelPortaliO76927
SMRiO76927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS21 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3486 Eukaryota
ENOG4112266 LUCA
GeneTreeiENSGT00390000017515
HOGENOMiHOG000236508
InParanoidiO76927
KOiK02971
OMAiCPRKCSA
OrthoDBiEOG091G113O
PhylomeDBiO76927

Family and domain databases

Gene3Di3.30.1230.20, 1 hit
InterProiView protein in InterPro
IPR001931 Ribosomal_S21e
IPR018279 Ribosomal_S21e_CS
IPR038579 Ribosomal_S21e_sf
PANTHERiPTHR10442 PTHR10442, 1 hit
PfamiView protein in Pfam
PF01249 Ribosomal_S21e, 1 hit
PIRSFiPIRSF002148 Ribosomal_S21e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006584 Ribosomal_S21e, 1 hit
PROSITEiView protein in PROSITE
PS00996 RIBOSOMAL_S21E, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: O76927-1) [UniParc]FASTAAdd to basket
Also known as: B1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENDAGENVD LYVPRKCSAS NRIIHAKDHA SVQLSIVDVD PETGRQTDGS
60 70 80
KTYAICGEIR RMGESDDCIV RLAKKDGIIT KNF
Length:83
Mass (Da):9,167
Last modified:November 1, 1998 - v1
Checksum:iDDFB9D498B3E1E05
GO
Isoform E1 Publication (identifier: O76927-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-83: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:81
Mass (Da):8,906
Checksum:i2D498B3E1E05C02F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03946382 – 83Missing in isoform E. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009557 Genomic DNA Translation: CAA08751.1
AE014134 Genomic DNA Translation: AAF51191.1
AE014134 Genomic DNA Translation: AAN10392.1
AE014134 Genomic DNA Translation: AAN10393.2
BT015189 mRNA Translation: AAT94418.1
RefSeqiNP_001259970.1, NM_001273041.1 [O76927-1]
NP_523462.2, NM_078738.5 [O76927-2]
NP_722853.1, NM_164506.4 [O76927-1]
NP_722854.1, NM_164507.4 [O76927-1]
NP_722855.1, NM_164508.3 [O76927-1]
UniGeneiDm.2727

Genome annotation databases

EnsemblMetazoaiFBtr0077621; FBpp0077307; FBgn0015521 [O76927-1]
FBtr0077622; FBpp0077308; FBgn0015521 [O76927-1]
FBtr0077623; FBpp0077309; FBgn0015521 [O76927-1]
FBtr0273293; FBpp0271801; FBgn0015521 [O76927-2]
FBtr0335131; FBpp0307130; FBgn0015521 [O76927-1]
GeneIDi33487
KEGGidme:Dmel_CG2986
UCSCiCG2986-RA d. melanogaster [O76927-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS21_DROME
AccessioniPrimary (citable) accession number: O76927
Secondary accession number(s): A4V027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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