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O76924 (ARI2_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ariadne-2
Short name=Ari-2
Gene names
Name:ari-2
Synonyms:ari2, TRIAD1
ORF Names:CG5709
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Subunit structure

Interacts with UbcD10.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the RBR family. Ariadne subfamily.

Contains 1 IBR-type zinc finger.

Contains 2 RING-type zinc fingers.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Protein ariadne-2
PRO_0000055757

Regions

Zinc finger153 – 20250RING-type 1; atypical
Zinc finger222 – 28463IBR-type
Zinc finger311 – 34030RING-type 2
Coiled coil387 – 41024 Potential
Coiled coil452 – 50352 Potential
Compositional bias2 – 6463Asp/Glu-rich (acidic)
Compositional bias123 – 1286Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
O76924 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 9FB82E5ACF05E900

FASTA50958,627
        10         20         30         40         50         60 
MDSDIEMDME SDNDGEYDDD YDYYNTGEDC DVERLDPKRA DPEYFEYECL TVEDIEKLLN 

        70         80         90        100        110        120 
ERVEKLNTIL QITPSLAKVL LLEHQWNNVA VVEKYRQDAN ALLVTARIKP PSVAVTDTAS 

       130        140        150        160        170        180 
TSAAAASAQL LRLGSSGYKT TASATPQYRS QMCPVCASSQ LGDKFYSLAC GHSFCKDCWT 

       190        200        210        220        230        240 
IYFETQIFQG ISTQIGCMAQ MCNVRVPEDL VLTLVTRPVM RDKYQQFAFK DYVKSHPELR 

       250        260        270        280        290        300 
FCPGPNCQII VQSSEISAKR AICKACHTGF CFRCGMDYHA PTDCQVIKKW LTKCADDSET 

       310        320        330        340        350        360 
ANYISAHTKD CPKCHICIEK NGGCNHMQCF NCKHDFCWMC LGDWKTHGSE YYECSRYKDN 

       370        380        390        400        410        420 
PNIANESVHV QAREALKKYL HYYERWENHS KSLKLEQQTI DRLRQRINSK VMNGSGTWID 

       430        440        450        460        470        480 
WQYLFNAAAL LAKCRYTLQY TYPYAYYMEA GSRKNLFEYQ QAQLEAEIEN LSWKIERAET 

       490        500 
TDLGDLENQM DIAEKRRTTL LKDFFPVDA

« Hide

References

« Hide 'large scale' references
[1]"Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins."
Aguilera M., Oliveros M., Martinez-Padron M., Barbas J.A., Ferrus A.
Genetics 155:1231-1244(2000) [PubMed: 10880484] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ010169 mRNA. Translation: CAA09030.1.
AE013599 Genomic DNA. Translation: AAF46823.1.
RefSeqNP_477374.1. NM_058026.3.
UniGeneDm.4783.

3D structure databases

ProteinModelPortalO76924.
SMRO76924. Positions 149-285, 303-359.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-17813N.
IntActO76924. 6 interactions.
MINTMINT-304091.
STRINGO76924.

Proteomic databases

PRIDEO76924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0071774; FBpp0071688; FBgn0025186.
GeneID37542.
KEGGdme:Dmel_CG5709.
NMPDRfig|7227.3.peg.6811.

Organism-specific databases

CTD37542.
FlyBaseFBgn0025186. ari-2.

Phylogenomic databases

eggNOGinNOG05346.
InParanoidO76924.
OMANCETIKK.
OrthoDBEOG4DBRVV.
PhylomeDBO76924.

Gene expression databases

BgeeO76924.
GermOnlineCG5709. Drosophila melanogaster.

Family and domain databases

InterProIPR002867. Znf_C6HC.
IPR001878. Znf_CCHC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK11969.
PfamPF01485. IBR. 2 hits.
[Graphical view]
SMARTSM00647. IBR. 2 hits.
SM00184. RING. 2 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio804182.

Entry information

Entry nameARI2_DROME
AccessionPrimary (citable) accession number: O76924
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents