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Protein

Protein ariadne-2

Gene

ari-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri153 – 20250RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 28463IBR-typeAdd
BLAST
Zinc fingeri311 – 34030RING-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ariadne-2
Short name:
Ari-2
Gene namesi
Name:ari-2
Synonyms:ari2, TRIAD1
ORF Names:CG5709
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0025186. ari-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Protein ariadne-2PRO_0000055757Add
BLAST

Proteomic databases

PaxDbiO76924.
PRIDEiO76924.

Expressioni

Gene expression databases

BgeeiFBgn0025186.
ExpressionAtlasiO76924. differential.
GenevisibleiO76924. DM.

Interactioni

Subunit structurei

Interacts with UbcD10.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi63159. 31 interactions.
DIPiDIP-17813N.
IntActiO76924. 6 interactions.
MINTiMINT-304091.
STRINGi7227.FBpp0071688.

Structurei

3D structure databases

ProteinModelPortaliO76924.
SMRiO76924. Positions 47-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili387 – 41024Sequence analysisAdd
BLAST
Coiled coili452 – 50352Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 6463Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi123 – 1286Poly-Ala

Sequence similaritiesi

Belongs to the RBR family. Ariadne subfamily.Curated
Contains 1 IBR-type zinc finger.Curated
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri153 – 20250RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 28463IBR-typeAdd
BLAST
Zinc fingeri311 – 34030RING-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1815. Eukaryota.
ENOG410XP9Y. LUCA.
GeneTreeiENSGT00840000129790.
InParanoidiO76924.
KOiK11969.
OMAiDCLTVED.
OrthoDBiEOG091G06CV.
PhylomeDBiO76924.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiPF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00647. IBR. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDIEMDME SDNDGEYDDD YDYYNTGEDC DVERLDPKRA DPEYFEYECL
60 70 80 90 100
TVEDIEKLLN ERVEKLNTIL QITPSLAKVL LLEHQWNNVA VVEKYRQDAN
110 120 130 140 150
ALLVTARIKP PSVAVTDTAS TSAAAASAQL LRLGSSGYKT TASATPQYRS
160 170 180 190 200
QMCPVCASSQ LGDKFYSLAC GHSFCKDCWT IYFETQIFQG ISTQIGCMAQ
210 220 230 240 250
MCNVRVPEDL VLTLVTRPVM RDKYQQFAFK DYVKSHPELR FCPGPNCQII
260 270 280 290 300
VQSSEISAKR AICKACHTGF CFRCGMDYHA PTDCQVIKKW LTKCADDSET
310 320 330 340 350
ANYISAHTKD CPKCHICIEK NGGCNHMQCF NCKHDFCWMC LGDWKTHGSE
360 370 380 390 400
YYECSRYKDN PNIANESVHV QAREALKKYL HYYERWENHS KSLKLEQQTI
410 420 430 440 450
DRLRQRINSK VMNGSGTWID WQYLFNAAAL LAKCRYTLQY TYPYAYYMEA
460 470 480 490 500
GSRKNLFEYQ QAQLEAEIEN LSWKIERAET TDLGDLENQM DIAEKRRTTL

LKDFFPVDA
Length:509
Mass (Da):58,627
Last modified:November 1, 1998 - v1
Checksum:i9FB82E5ACF05E900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010169 mRNA. Translation: CAA09030.1.
AE013599 Genomic DNA. Translation: AAF46823.1.
RefSeqiNP_477374.1. NM_058026.4.
UniGeneiDm.4783.

Genome annotation databases

EnsemblMetazoaiFBtr0071774; FBpp0071688; FBgn0025186.
GeneIDi37542.
KEGGidme:Dmel_CG5709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010169 mRNA. Translation: CAA09030.1.
AE013599 Genomic DNA. Translation: AAF46823.1.
RefSeqiNP_477374.1. NM_058026.4.
UniGeneiDm.4783.

3D structure databases

ProteinModelPortaliO76924.
SMRiO76924. Positions 47-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63159. 31 interactions.
DIPiDIP-17813N.
IntActiO76924. 6 interactions.
MINTiMINT-304091.
STRINGi7227.FBpp0071688.

Proteomic databases

PaxDbiO76924.
PRIDEiO76924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071774; FBpp0071688; FBgn0025186.
GeneIDi37542.
KEGGidme:Dmel_CG5709.

Organism-specific databases

CTDi37542.
FlyBaseiFBgn0025186. ari-2.

Phylogenomic databases

eggNOGiKOG1815. Eukaryota.
ENOG410XP9Y. LUCA.
GeneTreeiENSGT00840000129790.
InParanoidiO76924.
KOiK11969.
OMAiDCLTVED.
OrthoDBiEOG091G06CV.
PhylomeDBiO76924.

Miscellaneous databases

GenomeRNAii37542.
PROiO76924.

Gene expression databases

BgeeiFBgn0025186.
ExpressionAtlasiO76924. differential.
GenevisibleiO76924. DM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR031127. E3_UB_ligase_RBR.
IPR002867. IBR_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR11685. PTHR11685. 1 hit.
PfamiPF01485. IBR. 2 hits.
[Graphical view]
SMARTiSM00647. IBR. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARI2_DROME
AccessioniPrimary (citable) accession number: O76924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.