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Protein
Submitted name:

Drosophila homolog of transcription factor AP-2

Gene

TfAP-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • adult feeding behavior Source: FlyBase
  • adult locomotory behavior Source: FlyBase
  • imaginal disc-derived leg joint morphogenesis Source: FlyBase
  • imaginal disc-derived leg morphogenesis Source: FlyBase
  • imaginal disc-derived male genitalia development Source: FlyBase
  • inter-male aggressive behavior Source: FlyBase
  • male courtship behavior Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • proboscis development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-8864260. Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.
R-DME-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-DME-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-DME-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Names & Taxonomyi

Protein namesi
Submitted name:
Drosophila homolog of transcription factor AP-2Imported
Submitted name:
Transcription factor AP-2, isoform AImported
Gene namesi
Name:TfAP-2Imported
Synonyms:AP-2Imported, AP-2alphaImported, DAP-2Imported, dAP-2Imported, dAP-2alphaImported, Dmel\CG7807Imported, dTfap2Imported, l(3)1215Imported
ORF Names:CG7807Imported, Dmel_CG7807Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261953. TfAP-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0261953.

Interactioni

Protein-protein interaction databases

IntActiO76923. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 430TF_AP-2InterPro annotationAdd BLAST194

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
OrthoDBiEOG091G0PR6.

Family and domain databases

InterProiView protein in InterPro
IPR004979. TF_AP2.
IPR013854. TF_AP2_C.
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiView protein in Pfam
PF03299. TF_AP-2. 1 hit.
PRINTSiPR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

O76923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAYVDMPA VIQVQERLSG HGSLGLSSGS AAYTTHSGGH TGRSGPATGH
60 70 80 90 100
SGHSSTHGSA ATMHHQSLQS DFQPPYFPPP FHHSTQSPPQ QQNHGALEYL
110 120 130 140 150
GTDPYGQPLS SLHHAPLHHY NQLAGLRSTQ DQLGIHRTHR EAELQGHVTQ
160 170 180 190 200
LSHGFPYTDR RSDYGSAISA GAAHGTRLGH EHESLALHQA LQNAVDDVQA
210 220 230 240 250
PALDDNVAFM SDLPLIKSMK SGKEAGNIGS GSPSEVFCAV PGRLSLLSST
260 270 280 290 300
SKYKVTIAEV QRRLSPPECL NASLLGGVLR RAKSKNGGRL LREKLEKIGL
310 320 330 340 350
NLPAGRRKAA NVTLLTSLVE GEATHLAKDF HFVCETEFPA RQLAEYIVRH
360 370 380 390 400
QTEPQDSYRR KELILHSQQI TKELMQILSQ DRTTHFGTRS QHLLEPSMQR
410 420 430 440 450
HLTHFSLITH GFGSPAIMAV LHAFQTFLNE SLNYLEKLYP SNGGGMVSSS
460
LDKSKIDNEK K
Length:461
Mass (Da):50,343
Last modified:November 1, 1998 - v1
Checksum:i9A0FE9AE6EB4BEA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF51751.1.
AJ006868 mRNA. Translation: CAA07279.1.
RefSeqiNP_730664.1. NM_168927.2.
UniGeneiDm.3243.

Genome annotation databases

EnsemblMetazoaiFBtr0078419; FBpp0078073; FBgn0261953.
GeneIDi40398.
UCSCiCG7807-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO76923_DROME
AccessioniPrimary (citable) accession number: O76923
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported