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Protein
Submitted name:

EG:80H7.7 protein

Gene

Nmdar2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • NMDA glutamate receptor activity Source: FlyBase

GO - Biological processi

  • ionotropic glutamate receptor signaling pathway Source: FlyBase
  • long-term memory Source: FlyBase
  • medium-term memory Source: FlyBase
  • sensory perception of touch Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
EG:80H7.7 proteinImported
Gene namesi
Name:Nmdar2Imported
Synonyms:EG:80H7.7Imported
ORF Names:CG33513Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0053513. Nmdar2.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei481 – 50222HelicalSequence analysisAdd
BLAST
Transmembranei523 – 54119HelicalSequence analysisAdd
BLAST
Transmembranei553 – 57826HelicalSequence analysisAdd
BLAST
Transmembranei740 – 76021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: FlyBase
  • ionotropic glutamate receptor complex Source: FlyBase
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Proteomic databases

PaxDbiO76903.
PRIDEiO76903.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070276.

Structurei

3D structure databases

ProteinModelPortaliO76903.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini363 – 720358PBPeInterPro annotationAdd
BLAST
Domaini367 – 42559Lig_chan-Glu_bdInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

O76903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPDRPILST LCKEFLRVNV SAILYMMNNE QFGHSTASAQ YFLQLAGYLG
60 70 80 90 100
IPVISWNADN SGLERRASQS TLQLQLAPSI EHQSAAMLSI LERYKWHQFS
110 120 130 140 150
VVTSQIAGHD DFVQAVRERV AEMQEHFKFT ILNSIVVTRT SDLMELVNSE
160 170 180 190 200
ARVMLLYATQ TEAITILRAA EEMKLTGENY VWVVSQSVIE KKDAHSQFPV
210 220 230 240 250
GMLGVHFDTS SAALMNEISN AIKIYSYGVE AYLTDPANRD RRLTTQSLSC
260 270 280 290 300
EDEGRGRWDN GEIFFKYLRN VSIEGDLNKP NIEFTADGDL RSAELKIMNL
310 320 330 340 350
RPSANNKNLV WEEGVPEKFH LKITFLEEAP YINLSPADPV SGKCLMDRGV
360 370 380 390 400
LCRVAADHEM AADIDVGQAH RNESFYQCCS GFCIDLLEKF AEELGFTYEL
410 420 430 440 450
VRVEDGKWGT LENGKWNGLI ADLVNRKTDM VLTSLMINTE REAVVDFSEP
460 470 480 490 500
FMETGIAIVV AKRTGIISPT AFLEPFDTAS WMLVGIVAIQ AATFMIFLFE
510 520 530 540 550
WLSPSGYDMK LYLQNTNVTP YRFSLFRTYW LVWAVLFQAA VHVDSPRGFT
560 570 580 590 600
SRFMTNVWAL FAVVFLAIYT ANLAAFMITR EEFHEFSGLN DSRLVHPFSH
610 620 630 640 650
KPSFKFGTIP YSHTDSTIHK YFNVMHNYMR QYNKTSVADG VAAVLNGNLD
660 670 680 690 700
SFIYDGTVLD YLVAQDEDCR LMTVGSWYAM TGYGLAFSRN SKYVQMFNKR
710 720 730 740 750
LLEFRANGDL ERLRRYWMTG TCRPGKQEHK SSDPLALEQF LSAFLLLMAG
760 770 780 790 800
ILLAALLLLL EHVYFKYIRK RLAKKDGGHC CALISLSMGK SLTFRGAVFE
810 820 830 840 850
ATEILKKHRC NDPICDTHLW KVKHELDMSR LRVRQLEKVM DKHGIKAPQL
860 870 880 890 900
RLASSSDLLN HHHLKERPPL LGNLSLAASA QDLYRCCPSS CNPLPTGAAI
910 920 930 940 950
NGSGFPASSS EKLAASIPII VSISIGIAKL RTPPPVPPPQ VPMVRQSVNH
960 970 980 990 1000
SASVPLPGNT SPVLCGAGQH LYLCCSTTCQ PSSEPGAHCL GRLCGALLWG
1010
GCHSKGPADC GL
Length:1,012
Mass (Da):113,198
Last modified:November 1, 1998 - v1
Checksum:i6A2C401BA122429C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031027 Genomic DNA. Translation: CAA19838.1.
PIRiT13603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031027 Genomic DNA. Translation: CAA19838.1.
PIRiT13603.

3D structure databases

ProteinModelPortaliO76903.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070276.

Proteomic databases

PaxDbiO76903.
PRIDEiO76903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0053513. Nmdar2.

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequencing the distal X chromosome of Drosophila melanogaster."
    Mottier, Cadieu, Dreano, Lelaure, Galibert F.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Benos P.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76903_DROME
AccessioniPrimary (citable) accession number: O76903
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.