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Protein

Arginase

Gene

arg

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg), Arginase (arg)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processArginine metabolismUniRule annotation, Urea cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation
R-DME-70635 Urea cycle
UniPathwayiUPA00158; UER00270

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Name:argImported
Synonyms:ArgImported, Dmel\CG18104Imported, EG:171D11.4Imported, EG:65F1.3Imported
ORF Names:CG18104Imported, Dmel_CG18104Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023535 arg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO76895

Expressioni

Gene expression databases

BgeeiFBgn0023535
ExpressionAtlasiO76895 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070083

Structurei

3D structure databases

SMRiO76895
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965 Eukaryota
COG0010 LUCA
KOiK01476
OMAiEQECDVK
OrthoDBiEOG091G0A38

Family and domain databases

InterProiView protein in InterPro
IPR014033 Arginase
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01229 rocF_arginase, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWWSRKFASR SLRLHRLKST GSTAPREPEQ SLGIIGVPFA KGQAKQGVEL
60 70 80 90 100
APDLLRQSSL RQVLQSSHDG LVIRDYGNLQ YAVDEPLLQQ QRVHYHHIRN
110 120 130 140 150
YADFMACNRA LIEQVKLMLV ENTQFLAIGG DHAIGFGSVA GHLQHTPNLS
160 170 180 190 200
LVWIDAHADI NLHSTSQSGN IHGMPVSFLL EQLRNTWQHA GLQEIAPNCL
210 220 230 240 250
PKDQLVYIGL RDIDPYEAFI LNKVGIRYYA MDTIDRVGVP KIIEMTLDAL
260 270 280 290 300
NPQNKIHVSF DIDALDSNVA PSTGTAVRGG LTLREGISIV EALRDTKRVQ
310 320 330 340 350
GVDLVEINPK LGSERDVRTT VESGLEILKS MFGYRRSGRW SNIDTGILGS

D
Length:351
Mass (Da):39,086
Last modified:May 1, 1999 - v2
Checksum:i2D19D6D4004CDCB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239214 mRNA Translation: AAF40226.1
AE014298 Genomic DNA Translation: AAF45516.2
BT004504 mRNA Translation: AAO42668.1
AL009147, AL022139 Genomic DNA Translation: CAA15631.2
AL022139, AL009147 Genomic DNA Translation: CAA18092.2
PIRiT13422
RefSeqiNP_524875.1, NM_080136.3
UniGeneiDm.10614

Genome annotation databases

EnsemblMetazoaiFBtr0070088; FBpp0070083; FBgn0023535
GeneIDi46717
KEGGidme:Dmel_CG18104
UCSCiCG18104-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiO76895_DROME
AccessioniPrimary (citable) accession number: O76895
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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