Unreviewed, UniProtKB/TrEMBL O76895 (O76895_DROME)

Names and origin

Protein names

Submitted name:
    Arginase EMBL AAF40226.1
    EC=3.5.3.1
Submitted name:
    EG:171D11.4 protein EMBL CAA18092.2
    GH02581p EMBL AAO42668.1

Gene names

Name:	arg FlyBase FBgn0023535
Synonyms:	EG:171D11.4 EMBL CAA18092.2
ORF Names:	CG18104 FlyBase FBgn0023535, Dmel_CG18104 EMBL AAF45516.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome] EMBL CAA18092.2

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Manganese By similarity. RuleBase RU003684V1
Sequence similarities	Belongs to the arginase family. RuleBase RU003684V1

Ontologies

Keywords
Ligand	Manganese RuleBase RU003684V1 Metal-binding RuleBase RU003684V1
Molecular function	Hydrolase RuleBase RU003684V1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O76895-1 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: 2D19D6D4004CDCB7	FASTA	351	39,086
	10 20 30 40 50 60 MWWSRKFASR SLRLHRLKST GSTAPREPEQ SLGIIGVPFA KGQAKQGVEL APDLLRQSSL 70 80 90 100 110 120 RQVLQSSHDG LVIRDYGNLQ YAVDEPLLQQ QRVHYHHIRN YADFMACNRA LIEQVKLMLV 130 140 150 160 170 180 ENTQFLAIGG DHAIGFGSVA GHLQHTPNLS LVWIDAHADI NLHSTSQSGN IHGMPVSFLL 190 200 210 220 230 240 EQLRNTWQHA GLQEIAPNCL PKDQLVYIGL RDIDPYEAFI LNKVGIRYYA MDTIDRVGVP 250 260 270 280 290 300 KIIEMTLDAL NPQNKIHVSF DIDALDSNVA PSTGTAVRGG LTLREGISIV EALRDTKRVQ 310 320 330 340 350 GVDLVEINPK LGSERDVRTT VESGLEILKS MFGYRRSGRW SNIDTGILGS D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing the distal X chromosome of Drosophila melanogaster." Madueno E., de Pablos B., Modolell J. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Benos P. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAO42668.1.
[4]	"Sequencing the distal X chromosome of Drosophila melanogaster." Madueno E., de Pablos B., Modolell J. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Sequence of Drosophila arginase." Morris S.M.Jr., Kepka-Lenhart D. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Male and female head EMBL AAF40226.1.
[6]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[7]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF239214 mRNA. Translation: AAF40226.1. AE014298 Genomic DNA. Translation: AAF45516.2. BT004504 mRNA. Translation: AAO42668.1. AL009147, AL022139 Genomic DNA. Translation: CAA15631.2. AL022139, AL009147 Genomic DNA. Translation: CAA18092.2.
PIR	T13422.
RefSeq	NP_524875.1.
UniGene	Dm.10614
3D structure databases
HSSP	HSSP built from PDB template 1PQ3 based on UniProtKB P78540.
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0023535. Drosophila melanogaster. [Contig view]
GeneID	46717.
KEGG	dme:Dmel_CG18104.
Organism-specific databases
FlyBase	FBgn0023535. arg.
Phylogenomic databases
HOGENOM	O76895.
OMA	O76895. GVARYWQ.
Gene expression databases
ArrayExpress	O76895.
Family and domain databases
InterPro	IPR005924. Arginase. IPR014033. Arginase_sub. IPR006035. Ureohydrolase. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. rocF_arginase. 1 hit.
PROSITE	PS00148. ARGINASE_2. 1 hit. Uncertain. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	838864.

Entry information

Entry name

O76895_DROME

Accession

Primary (citable) accession number: O76895

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)