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Protein

Arginase

Gene

arg

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arg), Arginase (arg)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processArginine metabolismUniRule annotation, Urea cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-70635. Urea cycle.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Name:argImported
Synonyms:ArgImported, CG18104Imported, Dmel\CG18104Imported, EG:171D11.4Imported, EG:65F1.3Imported
ORF Names:Dmel_CG18104Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023535. arg.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0023535.
ExpressionAtlasiO76895. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070083.

Structurei

3D structure databases

SMRiO76895.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG091G0A38.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiView protein in InterPro
IPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
PfamiView protein in Pfam
PF00491. Arginase. 1 hit.
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
SUPFAMiSSF52768. SSF52768. 1 hit.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiView protein in PROSITE
PS51409. ARGINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWWSRKFASR SLRLHRLKST GSTAPREPEQ SLGIIGVPFA KGQAKQGVEL
60 70 80 90 100
APDLLRQSSL RQVLQSSHDG LVIRDYGNLQ YAVDEPLLQQ QRVHYHHIRN
110 120 130 140 150
YADFMACNRA LIEQVKLMLV ENTQFLAIGG DHAIGFGSVA GHLQHTPNLS
160 170 180 190 200
LVWIDAHADI NLHSTSQSGN IHGMPVSFLL EQLRNTWQHA GLQEIAPNCL
210 220 230 240 250
PKDQLVYIGL RDIDPYEAFI LNKVGIRYYA MDTIDRVGVP KIIEMTLDAL
260 270 280 290 300
NPQNKIHVSF DIDALDSNVA PSTGTAVRGG LTLREGISIV EALRDTKRVQ
310 320 330 340 350
GVDLVEINPK LGSERDVRTT VESGLEILKS MFGYRRSGRW SNIDTGILGS

D
Length:351
Mass (Da):39,086
Last modified:May 1, 1999 - v2
Checksum:i2D19D6D4004CDCB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239214 mRNA. Translation: AAF40226.1.
AE014298 Genomic DNA. Translation: AAF45516.2.
BT004504 mRNA. Translation: AAO42668.1.
AL009147, AL022139 Genomic DNA. Translation: CAA15631.2.
AL022139, AL009147 Genomic DNA. Translation: CAA18092.2.
PIRiT13422.
RefSeqiNP_524875.1. NM_080136.3.
UniGeneiDm.10614.

Genome annotation databases

EnsemblMetazoaiFBtr0070088; FBpp0070083; FBgn0023535.
GeneIDi46717.
KEGGidme:Dmel_CG18104.
UCSCiCG18104-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiO76895_DROME
AccessioniPrimary (citable) accession number: O76895
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported