Reviewed, UniProtKB/Swiss-Prot O76879 (CCCP_DROME)

Names and origin

Protein names

Recommended name:
    Circadian clock-controlled protein

Gene names

Name:	anon-3B1.2
ORF Names:	CG2650

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Component of the circadian clock or downstream effector of clock function.
Tissue specificity	Epidermis of newly eclosed adults. Ref.1
Developmental stage	Abundantly expressed during pupation and decreases rapidly with age. Expression is under pupal (eclosion) circadian clock control. Ref.1
Sequence similarities	Belongs to the TO family.

Ontologies

Keywords
Biological process	Biological rhythms
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	circadian rhythm Ref.1 Inferred from expression pattern. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 260	235	Circadian clock-controlled protein		PRO_0000020860
Natural variations
	Natural variant	219	1	Q → L in strain: Oregon-R, wi4, wi15, wi6, wi24, wi30, wi32 and wi33. Ref.6
Experimental info
	Sequence conflict	64 – 70	7	VAALEPI → SGRAGAHS Ref.1
	Sequence conflict	194	1	G → GSSPS Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O76879-1 [UniParc]. Last modified March 28, 2003. Version 2. Checksum: 8F2DA6F9A8E12323	FASTA	260	29,179
	10 20 30 40 50 60 MQLTGASMFL VWVGLLSWVS CRVDASEGFP SPLKRCKLQD ESCLLAQAQT FFQAFKNGIP 70 80 90 100 110 120 ERQVAALEPI ALGTMFIESG GHSESIKFKL TMSDAKLYNL ANSMMVKSLK GFTKDLTRPL 130 140 150 160 170 180 KLTLLLDNPE LEVRAKYDVD GKLLILPIVS KGDLTIRLND VHTKVWITAE PVKRSDGHTY 190 200 210 220 230 240 LNITDYKTAT KIKGGHFDLS NLFNDNKELR DSTLKVLNQE WSTLALDVQP KINEACAKAF 250 260 SAIVQSLWAN IPYDEFFEKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a Drosophila mRNA is under circadian clock control during pupation." Lorenz L.J., Hall J.C., Rosbash M. Development 107:869-880(1989) [PubMed: 2517256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon-R. Tissue: Head.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Oregon-R.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
[6]	"Single nucleotide polymorphisms derived from ancestral populations show no evidence for biased diversity estimates in Drosophila melanogaster." Schlotterer C., Harr B. Mol. Ecol. 11:947-950(2002) [PubMed: 11975710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 159-260, VARIANT LEU-219. Strain: AF1, AF2, AF3, AF4, K1, K11, K13, K14, K16, K17, K2, K20, K21, K3, K5, K7, K9, wi1, wi10, wi12, wi13, wi14, wi15, wi16, wi17, wi18, wi19, wi2, wi21, wi22, wi23, wi24, wi25, wi27, wi28, wi29, wi3, wi30, wi31, wi32, wi33, wi4, wi5, wi6, wi7, wi8, wi9, ZH1, ZH13, ZH16, ZH18, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31, ZH33, ZH35 and ZH36.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76206 Genomic DNA. Translation: CAA53799.1. AL024485 Genomic DNA. Translation: CAA19674.1. AE014298 Genomic DNA. Translation: AAF45805.2. AY071726 mRNA. Translation: AAL49348.1. AY047980 Genomic DNA. Translation: AAN02290.1. AY047981 Genomic DNA. Translation: AAN02292.1. AY047982 Genomic DNA. Translation: AAN02294.1. AY047983 Genomic DNA. Translation: AAN02296.1. AY047984 Genomic DNA. Translation: AAN02298.1. AY047985 Genomic DNA. Translation: AAN02300.1. AY047986 Genomic DNA. Translation: AAN02302.1. AY047987 Genomic DNA. Translation: AAN02304.1. AY047988 Genomic DNA. Translation: AAN02306.1. AY047989 Genomic DNA. Translation: AAN02308.1. AY047990 Genomic DNA. Translation: AAN02310.1. AY047991 Genomic DNA. Translation: AAN02312.1. AY047992 Genomic DNA. Translation: AAN02314.1. AY047993 Genomic DNA. Translation: AAN02316.1. AY047994 Genomic DNA. Translation: AAN02318.1. AY047995 Genomic DNA. Translation: AAN02320.1. AY047996 Genomic DNA. Translation: AAN02322.1. AY047997 Genomic DNA. Translation: AAN02324.1. AY047998 Genomic DNA. Translation: AAN02326.1. AY047999 Genomic DNA. Translation: AAN02328.1. AY048000 Genomic DNA. Translation: AAN02330.1. AY048001 Genomic DNA. Translation: AAN02332.1. AY048002 Genomic DNA. Translation: AAN02334.1. AY048003 Genomic DNA. Translation: AAN02336.1. AY048004 Genomic DNA. Translation: AAN02338.1. AY048005 Genomic DNA. Translation: AAN02340.1. AY048006 Genomic DNA. Translation: AAN02342.1. AY048007 Genomic DNA. Translation: AAN02344.1. AY048008 Genomic DNA. Translation: AAN02346.1. AY048009 Genomic DNA. Translation: AAN02348.1. AY048010 Genomic DNA. Translation: AAN02350.1. AY048011 Genomic DNA. Translation: AAN02352.1. AY048012 Genomic DNA. Translation: AAN02354.1. AY048013 Genomic DNA. Translation: AAN02356.1. AY048014 Genomic DNA. Translation: AAN02358.1. AY048015 Genomic DNA. Translation: AAN02360.1. AY048016 Genomic DNA. Translation: AAN02362.1. AY048017 Genomic DNA. Translation: AAN02364.1. AY048018 Genomic DNA. Translation: AAN02366.1. AY048019 Genomic DNA. Translation: AAN02368.1. AY048020 Genomic DNA. Translation: AAN02370.1. AY048021 Genomic DNA. Translation: AAN02372.1. AY048022 Genomic DNA. Translation: AAN02374.1. AY048023 Genomic DNA. Translation: AAN02376.1. AY048024 Genomic DNA. Translation: AAN02378.1. AY048025 Genomic DNA. Translation: AAN02380.1. AY048026 Genomic DNA. Translation: AAN02382.1. AY048027 Genomic DNA. Translation: AAN02384.1. AY048028 Genomic DNA. Translation: AAN02386.1. AY048029 Genomic DNA. Translation: AAN02388.1. AY048030 Genomic DNA. Translation: AAN02390.1. AY048031 Genomic DNA. Translation: AAN02392.1. AY048032 Genomic DNA. Translation: AAN02394.1. AY048033 Genomic DNA. Translation: AAN02396.1. AY048034 Genomic DNA. Translation: AAN02398.1. AY048035 Genomic DNA. Translation: AAN02400.1. AY048036 Genomic DNA. Translation: AAN02402.1. AY048037 Genomic DNA. Translation: AAN02404.1. AY048038 Genomic DNA. Translation: AAN02406.1. AY048040 Genomic DNA. Translation: AAN02408.1. AY048041 Genomic DNA. Translation: AAN02410.1. AY048042 Genomic DNA. Translation: AAN02412.1.
PIR	A60091.
RefSeq	NP_570016.1.
UniGene	Dm.5779
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0000092. Drosophila melanogaster. [Contig view]
GeneID	31252.
KEGG	dme:Dmel_CG2650.
NMPDR	fig|7227.3.peg.16284.
Organism-specific databases
FlyBase	FBgn0000092. CG2650.
Phylogenomic databases
HOGENOM	O76879.
OMA	O76879. PKINEAC.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-000397-MON.
Gene expression databases
GermOnline	CG2650. Drosophila melanogaster.
Family and domain databases
InterPro	IPR013053. Hormone_bd. IPR004272. Odorant_bd. [Graphical view]
Pfam	PF03027. DUF233. 1 hit. [Graphical view]
SMART	SM00700. JHBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	772676.

Entry information

Entry name

CCCP_DROME

Accession

Primary (citable) accession number: O76879
Secondary accession number(s): Q24484 , Q8MM43, Q8MM44, Q8SY82, Q9W4W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	March 28, 2003
Last modified:	June 16, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project