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Protein

Calcium-transporting ATPase

Gene

mca-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-5578775. Ion homeostasis.
R-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:mca-3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei86 – 10318HelicalUniRule annotationAdd
BLAST
Transmembranei123 – 14220HelicalUniRule annotationAdd
BLAST
Transmembranei330 – 35324HelicalUniRule annotationAdd
BLAST
Transmembranei373 – 40230HelicalUniRule annotationAdd
BLAST
Transmembranei823 – 84220HelicalUniRule annotationAdd
BLAST
Transmembranei854 – 87522HelicalUniRule annotationAdd
BLAST
Transmembranei896 – 91722HelicalUniRule annotationAdd
BLAST
Transmembranei937 – 95620HelicalUniRule annotationAdd
BLAST
Transmembranei976 – 99621HelicalUniRule annotationAdd
BLAST
Transmembranei1008 – 102922HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiO76832.
PaxDbiO76832.

Expressioni

Gene expression databases

ExpressionAtlasiO76832. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y67D8C.10b.4.

Structurei

3D structure databases

ProteinModelPortaliO76832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10375Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEYGASLEE LRALMEYRSA EAKEKIETDY GGTTGLCERL KTDPNNGLPN
60 70 80 90 100
NEEELERRRN VFGANEIPPH PPKCFLQLVW EALQDVTLVI LLVSAIVSLA
110 120 130 140 150
LSFYRPPGED TAGSDDSEHD AGWIEGVAIL ISVIVVVLVT ALNDYTKERQ
160 170 180 190 200
FRGLQAKIET EHRFFVLRGG QSVQVVVNEL VVGDIAQIKY GDLIPSDGII
210 220 230 240 250
IQSNDLKMDE SSLTGESDQI RKSPEHDPII LSGTHVMEGS GKMLVTAVGV
260 270 280 290 300
NSQTGIIMTL LGAAKTVAEE ERKTAKREGG DGASGAEEGT AQALLDSKGD
310 320 330 340 350
EAMANGKAVA AAESDGKKER SVLQAKLTRL AIQIGYAGSF VAGCTVLILI
360 370 380 390 400
IRFCISRYAI DGKSFSLADF QHFINFLIIG VTVLVVAVPE GLPLAVTLSL
410 420 430 440 450
AYSVKKMMLD NNLVRHLDAC ETMGNATAIC SDKTGTLTTN RMTVVQSFVN
460 470 480 490 500
DVHYKDTPKI ESLDQNTAKL MMDCISINSS YSSQVIPPKQ LGEQATQLGN
510 520 530 540 550
KTECGMLGFV LALGKSYQEI RDRHPEETIP KVYTFNSVRK SMSTVINLPD
560 570 580 590 600
GGYRVFSKGA SEIVTKRCKY FLGKNGTLTK FSSKDAENLV RDVIEPMASD
610 620 630 640 650
GLRTICVAYK DYVPSSKKTA DNQIAYSSEP DWENEEMIVG DMTAIAVLGI
660 670 680 690 700
QDPVRPEVPA AITRCQEAGI TVRMVTGDNI NTARSIATAC GILKPGEDFI
710 720 730 740 750
ALEGKEFNAR IRDENGEVSQ EKLDLIWPKL RVLARAQPSD KYVLVKGIID
760 770 780 790 800
SRVTDSREVV AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD
810 820 830 840 850
DNFTSIVKAV MWGRNVYDSI AKFLQFQLTV NVVAVVVAFV GACAIQDTPL
860 870 880 890 900
KAVQMLWVNL IMDTLASLAL ATEMPTEELL KRKPYGRTSP LISRTMCKYI
910 920 930 940 950
LGHAVYQLVI LFTLIFYGEV CFNIPSGRWA PLHSPPSKHF TIVFNTFVMM
960 970 980 990 1000
TLFNEINARK IHGERNIFKG LFSNPIYYVI WIATMISQVV IIQFGGRWFS
1010 1020 1030 1040 1050
TSALNTTEWL WCLAFGVGTL LWGQIVTSIP TGSLPANMTI GSGEAPTNDP
1060 1070 1080 1090 1100
LMPDYEDSDT HEKRSGQILW VRGLTRLQTQ LRVVKAFRSS LEEFDERRSI
1110 1120 1130 1140 1150
ASTHSVQSMR GGFWSGGGRH TTTAASPEPA GQRIAMAAIT HRQSPQPYPY
1160 1170 1180 1190 1200
YHHQQPRTPS PQPHIVVENG TSSGNNGQAA TAAAAAPKAE TNGKTEKVPL
1210 1220 1230
VQQWSPDTNS SYTQTQRTST RACLLILQFL LLTCNSF
Length:1,237
Mass (Da):135,272
Last modified:November 1, 1998 - v1
Checksum:iEE4089F3438562BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010646 Genomic DNA. Translation: CAA09303.1.

Genome annotation databases

UCSCiY67D8C.10c. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010646 Genomic DNA. Translation: CAA09303.1.

3D structure databases

ProteinModelPortaliO76832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y67D8C.10b.4.

Proteomic databases

EPDiO76832.
PaxDbiO76832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiY67D8C.10c. c. elegans.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.

Enzyme and pathway databases

ReactomeiR-CEL-418359. Reduction of cytosolic Ca++ levels.
R-CEL-5578775. Ion homeostasis.
R-CEL-936837. Ion transport by P-type ATPases.

Gene expression databases

ExpressionAtlasiO76832. baseline and differential.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Kraev A.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  2. "Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans."
    Kraev A., Kraev N., Carafoli E.
    J. Biol. Chem. 274:4254-4258(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO76832_CAEEL
AccessioniPrimary (citable) accession number: O76832
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.