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Protein

Nuclear hormone receptor family member nhr-42

Gene

nhr-42

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi7 – 8276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri10 – 3021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri48 – 7023NR C4-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-42
Gene namesi
Name:nhr-42
ORF Names:C33G8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC33G8.6; CE17496; WBGene00003632; nhr-42.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Nuclear hormone receptor family member nhr-42PRO_0000053781Add
BLAST

Proteomic databases

EPDiO76828.
PaxDbiO76828.
PRIDEiO76828.

Expressioni

Gene expression databases

ExpressionAtlasiO76828. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi44129. 2 interactions.
DIPiDIP-24601N.
IntActiO76828. 2 interactions.
MINTiMINT-1081417.
STRINGi6239.C33G8.6.

Structurei

3D structure databases

ProteinModelPortaliO76828.
SMRiO76828. Positions 10-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri10 – 3021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri48 – 7023NR C4-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00530000064422.
InParanoidiO76828.
OMAiIFRRCDR.
OrthoDBiEOG786H73.
PhylomeDBiO76828.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQTTSQTC LICGDSADSL HFGALSCRAC AAFFRRKVAG RRNIFRRCDR
60 70 80 90 100
QCKVDTGMRK LCASCRYDKC LKVGMRESAV LSRLAKKNQN YKKSIVGSPD
110 120 130 140 150
AYEPSTSTSD SVLENLQSAY HKLEETRKRV FNISETHVSQ CCNYKRMNDV
160 170 180 190 200
FFEDIKLVME HLLETFKKSD ISQEQEKLLC VHFMVPFILF EGGYKSTNSD
210 220 230 240 250
LFYLPSGDFI DENRIEEYYS NPDDQNDNSA KSAAEVFRPY WKLNKQTLKT
260 270 280 290 300
HLDDVQLDLP EFLFITALIY FDDGLLDQNE ECIEVCKQMK AKIIEELTDY
310 320 330 340 350
EKNVRINEDH SYRVGQIIMV LHGIQRTMNM IHETKEISLV YNVYDMHSSI

FGNMAE
Length:356
Mass (Da):41,297
Last modified:November 1, 1998 - v1
Checksum:iA0730EB20F4A64E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080765 Genomic DNA. Translation: CCD66530.1.
PIRiT34133.
RefSeqiNP_504771.1. NM_072370.3.
UniGeneiCel.2944.

Genome annotation databases

EnsemblMetazoaiC33G8.6; C33G8.6; WBGene00003632.
GeneIDi179084.
KEGGicel:CELE_C33G8.6.
UCSCiC33G8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080765 Genomic DNA. Translation: CCD66530.1.
PIRiT34133.
RefSeqiNP_504771.1. NM_072370.3.
UniGeneiCel.2944.

3D structure databases

ProteinModelPortaliO76828.
SMRiO76828. Positions 10-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44129. 2 interactions.
DIPiDIP-24601N.
IntActiO76828. 2 interactions.
MINTiMINT-1081417.
STRINGi6239.C33G8.6.

Proteomic databases

EPDiO76828.
PaxDbiO76828.
PRIDEiO76828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC33G8.6; C33G8.6; WBGene00003632.
GeneIDi179084.
KEGGicel:CELE_C33G8.6.
UCSCiC33G8.6. c. elegans.

Organism-specific databases

CTDi179084.
WormBaseiC33G8.6; CE17496; WBGene00003632; nhr-42.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00530000064422.
InParanoidiO76828.
OMAiIFRRCDR.
OrthoDBiEOG786H73.
PhylomeDBiO76828.

Miscellaneous databases

NextBioi903846.
PROiO76828.

Gene expression databases

ExpressionAtlasiO76828. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiNHR42_CAEEL
AccessioniPrimary (citable) accession number: O76828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.