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Protein

Nuclear hormone receptor family member nhr-42

Gene

nhr-42

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 82Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri10 – 30NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 70NR C4-type; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-42
Gene namesi
Name:nhr-42
ORF Names:C33G8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC33G8.6 ; CE17496 ; WBGene00003632 ; nhr-42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537811 – 356Nuclear hormone receptor family member nhr-42Add BLAST356

Proteomic databases

EPDiO76828
PaxDbiO76828

Expressioni

Gene expression databases

BgeeiWBGene00003632
ExpressionAtlasiO76828 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi44129, 2 interactors
DIPiDIP-24601N
IntActiO76828, 2 interactors
STRINGi6239.C33G8.6

Structurei

3D structure databases

ProteinModelPortaliO76828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 356NR LBDPROSITE-ProRule annotationAdd BLAST249

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri10 – 30NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri48 – 70NR C4-type; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00530000064422
InParanoidiO76828
OMAiIFRRCDR
OrthoDBiEOG091G0C6P
PhylomeDBiO76828

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQTTSQTC LICGDSADSL HFGALSCRAC AAFFRRKVAG RRNIFRRCDR
60 70 80 90 100
QCKVDTGMRK LCASCRYDKC LKVGMRESAV LSRLAKKNQN YKKSIVGSPD
110 120 130 140 150
AYEPSTSTSD SVLENLQSAY HKLEETRKRV FNISETHVSQ CCNYKRMNDV
160 170 180 190 200
FFEDIKLVME HLLETFKKSD ISQEQEKLLC VHFMVPFILF EGGYKSTNSD
210 220 230 240 250
LFYLPSGDFI DENRIEEYYS NPDDQNDNSA KSAAEVFRPY WKLNKQTLKT
260 270 280 290 300
HLDDVQLDLP EFLFITALIY FDDGLLDQNE ECIEVCKQMK AKIIEELTDY
310 320 330 340 350
EKNVRINEDH SYRVGQIIMV LHGIQRTMNM IHETKEISLV YNVYDMHSSI

FGNMAE
Length:356
Mass (Da):41,297
Last modified:November 1, 1998 - v1
Checksum:iA0730EB20F4A64E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080765 Genomic DNA Translation: CCD66530.1
PIRiT34133
RefSeqiNP_504771.1, NM_072370.3
UniGeneiCel.2944

Genome annotation databases

EnsemblMetazoaiC33G8.6; C33G8.6; WBGene00003632
GeneIDi179084
KEGGicel:CELE_C33G8.6
UCSCiC33G8.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNHR42_CAEEL
AccessioniPrimary (citable) accession number: O76828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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