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O76821 (FABP_ACASI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fatty acid-binding protein
Alternative name(s):
Allergen=Aca s 13
OrganismAcarus siro (Dust mite)
Taxonomic identifier66546 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataAcaroideaAcaridaeAcarinaeAcarus

Protein attributes

Sequence length64 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters By similarity.

Subcellular location

Cytoplasm Potential.

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
   DiseaseAllergen
   LigandLipid-binding
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›64›64Fatty acid-binding protein
PRO_0000067419

Experimental info

Non-terminal residue11
Non-terminal residue641

Sequences

Sequence LengthMass (Da)Tools
O76821 [UniParc].

Last modified January 1, 1999. Version 2.
Checksum: 030E8A9C0DF2E94A

FASTA647,059
        10         20         30         40         50         60 
QINGSYKLEK SDNFDAFLKE LGLNFVTRNL AKSATPTVEV SVNGDSYTIK TASTLKNTEI 


SFKL 

« Hide

References

[1]"Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins."
Eriksson T.L.J., Whitley P., Johansson E., van Hage-Hamsten M., Gafvelin G.
Int. Arch. Allergy Immunol. 119:275-281(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006774 mRNA. Translation: CAA07241.1.

3D structure databases

ProteinModelPortalO76821.
ModBaseSearch...

Protein family/group databases

Allergome2. Aca s 13.
3051. Aca s 13.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSPR00178. FATTYACIDBP.
SUPFAMSSF50814. Calycin. 1 hit.
PROSITEPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABP_ACASI
AccessionPrimary (citable) accession number: O76821
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1999
Last modified: April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Recent format changes

Overview of recent format changes

Allergens

Nomenclature of allergens and list of entries

SIMILARITY comments

Index of protein domains and families