Reviewed, UniProtKB/Swiss-Prot O76821 (FABP_ACASI)

Names and origin

Protein names	Recommended name:     Fatty acid-binding protein Alternative name(s):     Allergen=Aca s 13
Organism	Acarus siro (Dust mite)
Taxonomic identifier	66546 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Acaroidea › Acaridae › Acarinae › Acarus

Protein attributes

Sequence length	64 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters By similarity.
Subcellular location	Cytoplasm Potential.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Disease	Allergen
Ligand	Lipid-binding
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›64	›64	Fatty acid-binding protein		PRO_0000067419
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	64	1

Sequences

	Sequence		Length	Mass (Da)
	O76821-1 [UniParc]. Last modified January 1, 1999. Version 2. Checksum: 030E8A9C0DF2E94A	FASTA	64	7,059
	10 20 30 40 50 60 QINGSYKLEK SDNFDAFLKE LGLNFVTRNL AKSATPTVEV SVNGDSYTIK TASTLKNTEI SFKL

References

[1]

"Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins." Eriksson T.L.J., Whitley P., Johansson E., van Hage-Hamsten M., Gafvelin G. Int. Arch. Allergy Immunol. 119:275-281(1999) [PubMed: 10474032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ006774 mRNA. Translation: CAA07241.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid_bd. IPR000566. Lipocln_cytFABP. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
PANTHER	PTHR11955. Fatty_acid_bd. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABP_ACASI

Accession

Primary (citable) accession number: O76821

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 1, 1999
Last modified:	November 24, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)