O76821 (FABP_ACASI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Fatty acid-binding protein Alternative name(s): Allergen=Aca s 13
Organism	Acarus siro (Dust mite)
Taxonomic identifier	66546 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Acaroidea › Acaridae › Acarinae › Acarus

Protein attributes

Sequence length	64 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters By similarity.
Subcellular location	Cytoplasm Potential.
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Disease	Allergen
Ligand	Lipid-binding
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›64	›64	Fatty acid-binding protein		PRO_0000067419
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	64	1

Sequences

	Sequence		Length	Mass (Da)
	O76821 [UniParc]. Last modified January 1, 1999. Version 2. Checksum: 030E8A9C0DF2E94A	FASTA	64	7,059
	10 20 30 40 50 60 QINGSYKLEK SDNFDAFLKE LGLNFVTRNL AKSATPTVEV SVNGDSYTIK TASTLKNTEI SFKL

References

[1]

"Identification and characterisation of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins." Eriksson T.L.J., Whitley P., Johansson E., van Hage-Hamsten M., Gafvelin G. Int. Arch. Allergy Immunol. 119:275-281(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006774 mRNA. Translation: CAA07241.1.
3D structure databases
ProteinModelPortal	O76821.
ModBase	Search...
Protein family/group databases
Allergome	2. Aca s 13. 3051. Aca s 13.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000463. Fatty_acid-bd. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR00178. FATTYACIDBP.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00214. FABP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABP_ACASI

Accession

Primary (citable) accession number: O76821

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 1, 1999
Last modified:	April 3, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)