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Protein

PBAN-type neuropeptides

Gene
N/A
Organism
Agrotis ipsilon (Black cutworm moth)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pheromone biosynthesis-activating neuropeptide: A hormone that controls sex pheromone production in female moths and pheromone responsiveness in male (PubMed:9753769).1 Publication

Miscellaneous

Juvenile hormone seems to allow PBAN release, which then induces pheromone biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Neuropeptide
Biological processPheromone response

Names & Taxonomyi

Protein namesi
Recommended name:
PBAN-type neuropeptides
Alternative name(s):
Pheromone/pyrokinin biosynthesis-activating neuropeptide
Cleaved into the following 8 chains:
Diapause hormone1 Publication
Short name:
DH
PBAN precursor-related peptide 11 Publication
Short name:
PBAN-PP-11 Publication
PBAN precursor-related peptide 21 Publication
Short name:
PBAN-PP-21 Publication
Alpha-subesophageal ganglion neuropeptide1 Publication
Alternative name(s):
Alpha-SG neuropeptide1 Publication
Short name:
Alpha-SGNP1 Publication
Beta-subesophageal ganglion neuropeptide1 Publication
Alternative name(s):
Beta-SG neuropeptide1 Publication
Short name:
Beta-SGNP1 Publication
Pyrokinin-1
Pheromone biosynthesis-activating neuropeptide1 Publication
Short name:
Agi-PBAN1 Publication
Alternative name(s):
Pyrokinin-2
Gamma-subesophageal ganglion neuropeptide1 Publication
Alternative name(s):
Gamma-SG neuropeptide1 Publication
Short name:
Gamma-SGNP1 Publication
Pyrokinin-3
PBAN precursor-related peptide 31 Publication
Short name:
PBAN-PP-31 Publication
OrganismiAgrotis ipsilon (Black cutworm moth)
Taxonomic identifieri56364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeNoctuinaeAgrotis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000044416020 – 46Diapause hormone1 PublicationAdd BLAST27
PeptideiPRO_000044416150 – 74PBAN precursor-related peptide 11 PublicationAdd BLAST25
PeptideiPRO_000044416275 – 93PBAN precursor-related peptide 21 PublicationAdd BLAST19
PeptideiPRO_000002991696 – 102Alpha-subesophageal ganglion neuropeptide1 Publication7
PeptideiPRO_0000029917105 – 122Beta-subesophageal ganglion neuropeptide1 PublicationAdd BLAST18
PeptideiPRO_0000029918126 – 158Pheromone biosynthesis-activating neuropeptide1 PublicationAdd BLAST33
PeptideiPRO_0000029919161 – 168Gamma-subesophageal ganglion neuropeptide1 Publication8
PeptideiPRO_0000444163171 – 184PBAN precursor-related peptide 31 PublicationAdd BLAST14
PropeptideiPRO_0000444164186 – 193Curated8

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Isoleucine amide1 Publication1
Modified residuei102Leucine amide1 Publication1
Modified residuei122Leucine amide1 Publication1
Modified residuei158Leucine amideBy similarity1
Modified residuei168Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiO76818

Expressioni

Tissue specificityi

Pheromone biosynthesis-activating neuropeptide: Expressed in the mandibular, maxillary and labial neuromeres of the male and female brain-subesophageal ganglions, in the corpora cardiaca and all around the corpora allata, and at a lower level in the brain near the calyx and pedunculus of the mushroom body (at protein level) (PubMed:9753769). Expressed in larvae and adult of both sexes (at protein level) (PubMed:9753769). Diapause hormone: Expressed in corpora cardiaca (CC), corpora allata (CA) and gnathal ganglion (GNG) (at protein level) (PubMed:29466015). Expression in CC and CA detected in most animals, in GNG in some (at protein level) (PubMed:29466015). PBAN precursor-related peptide 1: Expression not detected in CC, CA, AL or GNG (at protein level) (PubMed:29466015). PBAN precursor-related peptide 2: Expression not detected in CC, CA, AL or GNG (at protein level) (PubMed:29466015). Alpha-subesophageal ganglion neuropeptide: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level) (PubMed:29466015). Expression in CC, CA and GNG detected in most animals, expression in AL detected in few (at protein level) (PubMed:29466015). Beta-subesophageal ganglion neuropeptide: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level) (PubMed:29466015). Expression in CC, CA and GNG detected in most animals, expression in AL detected in few (at protein level) (PubMed:29466015). Gamma-subesophageal ganglion neuropeptide: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level) (PubMed:29466015). Expression in CC, CA and GNG detected in all animals, expression in AL detected in some (at protein level) (PubMed:29466015). PBAN precursor-related peptide 3: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level) (PubMed:29466015). Expression in CC, CA and GNG detected in most animals, expression in AL detected in some animals (at protein level) (PubMed:29466015).2 Publications

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrokinin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR008730 PBAN
IPR001484 Pyrokinin_CS
PfamiView protein in Pfam
PF05874 PBAN, 1 hit
PROSITEiView protein in PROSITE
PS00539 PYROKININ, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGAVLPGLF FIFISCVVAS SNDVKDGGAD RGAHSDRGGM WFGPRIGKRS
60 70 80 90 100
LRMATEDNRQ AFFKLLEAAD ALKYYYDQLP YEMQADEPEA RVTKKVIFTP
110 120 130 140 150
KLGRSLSYED KMFDNVEFTP RLGRRLADDT PATPADQEMY RPDPEQIDSR
160 170 180 190
TKYFSPRLGR TMNFSPRLGR ELAYEMLPSK VRVVRSTNKT QST
Length:193
Mass (Da):22,014
Last modified:November 1, 1998 - v1
Checksum:i7F66D4080430DE18
GO

Mass spectrometryi

Molecular mass is 2844.31±0.01 Da from positions 20 - 46. Determined by MALDI. Diapause hormone.1 Publication
Molecular mass is 2901.54±0.01 Da from positions 50 - 74. Determined by MALDI. PBAN precursor-related peptide 1.1 Publication
Molecular mass is 2318.01±0.01 Da from positions 75 - 93. Determined by MALDI. PBAN precursor-related peptide 2.1 Publication
Molecular mass is 816.47±0.01 Da from positions 96 - 102. Determined by MALDI. Alpha-subesophageal ganglion neuropeptide.1 Publication
Molecular mass is 2190.06±0.01 Da from positions 105 - 122. Determined by MALDI. Beta-subesophageal ganglion neuropeptide.1 Publication
Molecular mass is 964.50±0.01 Da from positions 161 - 168. Determined by MALDI. Gamma-subesophageal ganglion neuropeptide.1 Publication
Molecular mass is 1633.90±0.01 Da from positions 171 - 184. Determined by MALDI. PBAN precursor-related peptide 3.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009674 mRNA Translation: CAA08774.1

Similar proteinsi

Entry informationi

Entry nameiPBAN_AGRIP
AccessioniPrimary (citable) accession number: O76818
Secondary accession number(s): C0HKV1
, C0HKV2, C0HKV3, C0HKV4, C0HKV5, C0HKV6, C0HKV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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