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Protein
Submitted name:

Calexcitin

Gene

cex

Organism
Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Calcium 1Combined sources
Metal bindingi25 – 251Calcium 1Combined sources
Metal bindingi27 – 271Calcium 1Combined sources
Metal bindingi29 – 291Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi34 – 341Calcium 1Combined sources
Metal bindingi74 – 741Calcium 2Combined sources
Metal bindingi76 – 761Calcium 2Combined sources
Metal bindingi78 – 781Calcium 2Combined sources
Metal bindingi80 – 801Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi85 – 851Calcium 2Combined sources
Metal bindingi119 – 1191Calcium 3Combined sources
Metal bindingi121 – 1211Calcium 3Combined sources
Metal bindingi123 – 1231Calcium 3Combined sources
Metal bindingi125 – 1251Calcium 3; via carbonyl oxygenCombined sources
Metal bindingi130 – 1301Calcium 3Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
CalexcitinImported
Gene namesi
Name:cexImported
OrganismiDoryteuthis pealeii (Longfin inshore squid) (Loligo pealeii)Imported
Taxonomic identifieri1051067 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeDoryteuthis

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CCMX-ray1.80A/B1-191[»]
4NDBX-ray2.00A/B1-191[»]
4NDCX-ray2.00A/B1-191[»]
4NDDX-ray2.90A/B1-191[»]
5F6TX-ray2.20A1-191[»]
ProteinModelPortaliO76764.
SMRiO76764. Positions 2-191.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76764.

Family & Domainsi

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHQLSDFQ RNKILRVFNT FYDCNHDGVI EWDDFELAIK KICNLHSWPT
60 70 80 90 100
DGKKHNEARA TLKLIWDGLR KYADENEDEQ VTKEEWLKMW AECVKSVEKG
110 120 130 140 150
ESLPEWLTKY MNFMFDVNDT SGDNIIDKHE YSTVYMSYGI PKSDCDAAFD
160 170 180 190
TLSDGGKTMV TREIFARLWT EYFVSNDRGA KGNHLFGTLK L
Length:191
Mass (Da):22,271
Last modified:November 1, 1998 - v1
Checksum:iEBB30CE5E382D604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080588 mRNA. Translation: AAC32271.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080588 mRNA. Translation: AAC32271.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CCMX-ray1.80A/B1-191[»]
4NDBX-ray2.00A/B1-191[»]
4NDCX-ray2.00A/B1-191[»]
4NDDX-ray2.90A/B1-191[»]
5F6TX-ray2.20A1-191[»]
ProteinModelPortaliO76764.
SMRiO76764. Positions 2-191.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO76764.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Invertebrate cex genes: neuron-specific, Ca2+ sensing small GTPases."
    Quattrone A., Nelson T.J., Alkon D.L.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Optic lobeImported.
  2. "Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory."
    Erskine P.T., Beaven G.D., Hagan R., Findlow I.S., Werner J.M., Wood S.P., Vernon J., Giese K.P., Fox G., Cooper J.B.
    J. Mol. Biol. 357:1536-1547(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH CALCIUM.
  3. "X-ray, spectroscopic and normal-mode dynamics of calexcitin: structure-function studies of a neuronal calcium-signalling protein."
    Erskine P.T., Fokas A., Muriithi C., Rehman H., Yates L.A., Bowyer A., Findlow I.S., Hagan R., Werner J.M., Miles A.J., Wallace B.A., Wells S.A., Wood S.P., Cooper J.B.
    Acta Crystallogr. D 71:615-631(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH CALCIUM.
  4. "Binding of Gd 3+ ions to the neuronal signalling protein calexcitinidentifies an exchangeable calcium site."
    Chataigner L., Guo J., Erskine P.T., Coker A.R., Wood S.P., Gombos Z., Cooper J.B.
    Acta Crystallogr. F Struct. Biol. Commun. 72:276-281(2016)
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).

Entry informationi

Entry nameiO76764_DORPE
AccessioniPrimary (citable) accession number: O76764
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.