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Protein

Homeobox protein abdominal-A homolog

Gene

abd-A

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi138 – 19760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein abdominal-A homolog
Gene namesi
Name:abd-AImported
ORF Names:AGAP004662
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 2R

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Homeobox protein abdominal-A homologPRO_0000343523Add
BLAST

Proteomic databases

PaxDbiO76762.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP004662-PB.

Structurei

3D structure databases

ProteinModelPortaliO76762.
SMRiO76762. Positions 138-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi249 – 29951Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000231181.
InParanoidiO76762.
KOiK09311.
OMAiFASTDWM.
OrthoDBiEOG780RP4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022132. Abdominal-A.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPFVSNHPT THTSYSTMPG FSGLDDKSCS SRYTDSVMNS YPPMGVPGSA
60 70 80 90 100
SIAQFYQQAA AVSAASAGVG VDSLGSACSQ LSSSVGGAQS GLPDITRHPW
110 120 130 140 150
LVTASQSALQ KFASTDWMSN PFDRVVCGDF AGPNGCPRRR GRQTYTRFQT
160 170 180 190 200
LELEKEFHFN HYLTRRRRIE IAHALCLTER QIKIWFQNRR MKLKKELRAV
210 220 230 240 250
KEINEQARRE REEQDKMKNE SLKSAQQHHS QKQAQQEHTV VGSQQTSNGG
260 270 280 290 300
GTGGGTGGSG GAGSGGSSGN LGSHLHHPSI VSQNDLKLGL GGMGVGVGGN

LSMMGAQT
Length:308
Mass (Da):33,137
Last modified:November 1, 1998 - v1
Checksum:i5B25ABC97769C6F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080566 mRNA. Translation: AAC31946.1.
AAAB01008850 Genomic DNA. Translation: EAA07261.6.
RefSeqiXP_311627.4. XM_311627.4.

Genome annotation databases

EnsemblMetazoaiAGAP004662-RA; AGAP004662-PA; AGAP004662.
AGAP004662-RB; AGAP004662-PB; AGAP004662.
GeneIDi1272718.
KEGGiaga:AgaP_AGAP004662.
VectorBaseiAGAP004662. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080566 mRNA. Translation: AAC31946.1.
AAAB01008850 Genomic DNA. Translation: EAA07261.6.
RefSeqiXP_311627.4. XM_311627.4.

3D structure databases

ProteinModelPortaliO76762.
SMRiO76762. Positions 138-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP004662-PB.

Proteomic databases

PaxDbiO76762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP004662-RA; AGAP004662-PA; AGAP004662.
AGAP004662-RB; AGAP004662-PB; AGAP004662.
GeneIDi1272718.
KEGGiaga:AgaP_AGAP004662.
VectorBaseiAGAP004662. Anopheles gambiae.

Organism-specific databases

CTDi1272718.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000231181.
InParanoidiO76762.
KOiK09311.
OMAiFASTDWM.
OrthoDBiEOG780RP4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022132. Abdominal-A.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Hox gene cluster in the malaria vector mosquito, Anopheles gambiae."
    Devenport M.P., Blass C., Eggleston P.
    Evol. Dev. 2:326-339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: G3Imported.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiABDA_ANOGA
AccessioniPrimary (citable) accession number: O76762
Secondary accession number(s): Q7PRF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.