O76755 (O76755_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Mitotic checkpoint control protein kinase BUB1 EMBL AAC32190.1

Gene names

Name:	BubR1 FlyBase FBgn0025458
Synonyms:	Bub1 EMBL AAC32190.1
ORF Names:	CG7838 FlyBase FBgn0025458

Organism

Drosophila melanogaster (Fruit fly) EMBL AAC32190.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Gene Ontology (GO)
Biological process	mitotic cell cycle spindle assembly checkpoint Inferred from direct assay. Source: FlyBase mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase regulation of exit from mitosis Inferred from mutant phenotype. Source: FlyBase regulation of mitotic prometaphase Inferred from mutant phenotype. Source: FlyBase regulation of mitotic sister chromatid separation Inferred from mutant phenotype. Source: FlyBase sister chromatid segregation Inferred from mutant phenotype. Source: FlyBase syncytial blastoderm mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase
Cellular component	condensed chromosome outer kinetochore Non-traceable author statement. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O76755 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 559EE12CA49E2BFF	FASTA	1,461	165,455
	10 20 30 40 50 60 MDFDNAKENI QPLASGRNVS LLQASLSQDS THGQELLAQR KQMEEEVRTY KGADPLGAWY 70 80 90 100 110 120 TFICWIEQSY PAGGSGSGLQ TVLHQCLTKF EDDERYRQDK RLIKLFIKFM EKQKDKIEFY 130 140 150 160 170 180 QQMYNNGIGT MLADFYIAWA YSYDLSGNMR KADEIFRLGL ECRAEPLEDL KEAHHHFGYT 190 200 210 220 230 240 VGQRMLYSTG EEANAVNQEL NERRLALQSL HGRRQQISNS ITVGSIRTGA AVKSGLPGVV 250 260 270 280 290 300 QVEPSTTTSR RNVGRNVEVF NDENSEGNIP ISNSETEVKS SLRSIIDSAC SQENIKEPVA 310 320 330 340 350 360 WNKANAKRHK HGKIFGSNAS PDLGFDIHVD EQAMPPITNY DVRLEQPFRF PTNFVAKNRP 370 380 390 400 410 420 QEPWVTPVTI EDEPNASGLP CYNKCLLYPR PNIEFSPEEY RAYSFLKHRN PQHPFIHRND 430 440 450 460 470 480 DWWGTGRVIR GIRCYPNFAR YSKPQDLDEL DKFWKPPLVP GLQVVFDKIY NEVEQKEYQP 490 500 510 520 530 540 EELLAAKWME KRNVTVHGDF DMEETVCLPG NKMPRRKSFF PSSFRKSIMP RRVSSVQEED 550 560 570 580 590 600 EKKEDEATLI VKDIPSQVAP KIPESPCDQI DEPKIKIFED SGSPRDNFAV PAVPVPKIEI 610 620 630 640 650 660 YEDSEEPQPT PKTRPFYDGD ETCSTQMFNM FIKSQAVSTP KGTQKQAPVT SIWNPCSKNY 670 680 690 700 710 720 RYQRRLLIPS NLQWRLVLQL CESNLSTILE TSEHGTQSLA TSGTTTKSTI TSTSSPGSNA 730 740 750 760 770 780 VSKLGSKIEE NTPGQMRLQR VISAGVSAVL SEPEKPGGDN FLRRELWEPN APSVPMLKSL 790 800 810 820 830 840 RFQEDKTETI PRPLACFQED KTETLPQMPI ALPENSMDHG SLGAENCFSA PQLPTLEDES 850 860 870 880 890 900 DLCGLFGKTP PKTNIFGSSK RNFDPTSQLF KSTQGDRRSF AVTGNKLEAA PSISNLQDSF 910 920 930 940 950 960 MCDLSFVPET QPEAVAKSGA IQKFDIFLDD TQPKLTKSKP VALMVSSFDL DCTLPETQQV 970 980 990 1000 1010 1020 AIKEPGTQQE NIGHSHMIAS FMKDCTEIGS CPSQMPASVV KTNISSTSNK IKFSNDSMSE 1030 1040 1050 1060 1070 1080 SSRKAPVNEN VGISKQPDEF FELNAATEMF ATNISMIKNS TLLIPNAKVA EASELSIYYK 1090 1100 1110 1120 1130 1140 TTPLTPKQSH RSWSQSDLET PPRENFVHPT SNGDQTVLNE TLADANKNPF NVELISSLLE 1150 1160 1170 1180 1190 1200 SIDFSMYIEK LPHCQLVGHV KRLHPNTHLE VHNEKFEVSK MIGKGAYGSV YVGKHLKSGK 1210 1220 1230 1240 1250 1260 KVALKQERPT NYWEFYICLE IHSRLTSEQM IPSYAHIDYA LVGNNSSVYI SEFSDYGSLI 1270 1280 1290 1300 1310 1320 GVCNKVKSVT NRNMDEYVVM HLSCQMLDIV DHLHAMGIIH ADIKPDNFLL MKPICADPNE 1330 1340 1350 1360 1370 1380 VSLQLIDFGV SIDMKLFPDN QTFNYVHHDD LFKCIEMRTG RPWTYQLDLY GLVSVMHVLL 1390 1400 1410 1420 1430 1440 FGRYMEVVQR SPSTIWMPKT NVPRYFQRTM WENIFRTLLN IRDCRTMPNL QQLRTQLKCA 1450 1460 LAEKEKYVAE AISKFNTILQ K

References

[1]	"Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila." Basu J., Bousbaa H., Logarinho E., Li Z., Williams B.C., Lopes C., Sunkel C.E., Goldberg M.L. J. Cell Biol. 146:13-28(1999) [PubMed: 10402457] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF080399 mRNA. Translation: AAC32190.1.
PIR	T13157.
3D structure databases
ProteinModelPortal	O76755.
ModBase	Search...
Protein-protein interaction databases
STRING	O76755.
Proteomic databases
PRIDE	O76755.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0025458. BubR1.
Phylogenomic databases
InParanoid	O76755.
PhylomeDB	O76755.
Gene expression databases
ArrayExpress	O76755.
Bgee	O76755.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR013212. Mad3_BUB1_I. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR015661. Ser/Thr_kinase_Bub1. [Graphical view]
PANTHER	PTHR14030. Bub1. 1 hit.
Pfam	PF08311. Mad3_BUB1_I. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00777. Mad3_BUB1_I. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51489. BUB1_N. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O76755_DROME

Accession

Primary (citable) accession number: O76755

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)