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Protein

General transcriptional corepressor tupA

Gene

tupA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as component of the trfA-tupA corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcriptional corepressor tupA
Gene namesi
Name:tupA
Synonyms:tup1
ORF Names:DDB_G0282189
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282189. tupA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003273931 – 579General transcriptional corepressor tupAAdd BLAST579

Proteomic databases

PaxDbiO76734.
PRIDEiO76734.

Interactioni

Subunit structurei

Associates with trfA to form the trfA-tupA corepressor complex.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0214909.

Structurei

3D structure databases

ProteinModelPortaliO76734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati279 – 319WD 1Add BLAST41
Repeati325 – 364WD 2Add BLAST40
Repeati367 – 406WD 3Add BLAST40
Repeati413 – 452WD 4Add BLAST40
Repeati455 – 494WD 5Add BLAST40
Repeati501 – 540WD 6Add BLAST40
Repeati543 – 579WD 7Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 114Poly-Asn6
Compositional biasi117 – 128Poly-AsnAdd BLAST12
Compositional biasi174 – 186Poly-GlnAdd BLAST13
Compositional biasi219 – 226Poly-Asn8

Sequence similaritiesi

Belongs to the WD repeat TUP1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
InParanoidiO76734.
KOiK06666.
OMAiGKKSSCD.
PhylomeDBiO76734.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGRTARASE LLDNLKGEID ALNHELSLYK HQKDDYERKF QNQLAELNTI
60 70 80 90 100
QQTLYDLERG QNKMKIHYEE EIRQLKRQLE QQNINASQRD LNSPSTFRSN
110 120 130 140 150
SPAPPAQHNN NNNNIINNNN NNNNNNNNMQ RNTPTPTIPD KGQPKQRQRS
160 170 180 190 200
GSGEFYQQPG LGPQQLNFQQ LNLQQQQQQL QQQQQQGSGQ SFPSLSPLDS
210 220 230 240 250
NRHPKEMGNN MSGNSMSMNN NNNNLNKKPD MEEVKEEDRR RHDTEMSEEN
260 270 280 290 300
GKEKGTDWLV GYNPSVQTNL NIDLLHNLQH NSVVCCVNFS NDGKYLATGC
310 320 330 340 350
NRSAQIYDVD TGKKVHAFVD ESEKDGDLYI RSVCFSPDGN YLATGAEDKT
360 370 380 390 400
VKVWDIHTKK IQHTFYGHEL DIYSLDYSSD GRFIVSGSGD KKAKIWDIEK
410 420 430 440 450
GKCAFTLGNE EVGPKNGVTS VAMSPDGRLV AAGSLDNIVR LWDAQTGYFL
460 470 480 490 500
ERYEGHLDSV YSVAFSPDGK SLASGSLDKS LKLWDLSGSR SRSRCRATFN
510 520 530 540 550
GHKDFVLSVA FSPDGSWLIS GSKDRSVQFW DPRNGTTHMM LQGHKNSVIS
560 570
VALSPKNNSH GVFATGSGDF RSRLWKYDS
Length:579
Mass (Da):65,300
Last modified:November 1, 1998 - v1
Checksum:iA01D52AEA1F5D7B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079369 mRNA. Translation: AAC29438.1.
AAFI02000046 Genomic DNA. Translation: EAL66300.1.
RefSeqiXP_640309.1. XM_635217.1.

Genome annotation databases

EnsemblProtistsiEAL66300; EAL66300; DDB_G0282189.
GeneIDi8623485.
KEGGiddi:DDB_G0282189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079369 mRNA. Translation: AAC29438.1.
AAFI02000046 Genomic DNA. Translation: EAL66300.1.
RefSeqiXP_640309.1. XM_635217.1.

3D structure databases

ProteinModelPortaliO76734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214909.

Proteomic databases

PaxDbiO76734.
PRIDEiO76734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66300; EAL66300; DDB_G0282189.
GeneIDi8623485.
KEGGiddi:DDB_G0282189.

Organism-specific databases

dictyBaseiDDB_G0282189. tupA.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
InParanoidiO76734.
KOiK06666.
OMAiGKKSSCD.
PhylomeDBiO76734.

Miscellaneous databases

PROiO76734.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUP1_DICDI
AccessioniPrimary (citable) accession number: O76734
Secondary accession number(s): Q54SS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.