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Protein

Carboxypeptidase

Gene

ctsa-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotationImported, Hydrolase, Protease

Protein family/group databases

ESTHERicaeel-Y40D12A.2. Carboxypeptidase_S10.
MEROPSiS10.A54.

Names & Taxonomyi

Protein namesi
Recommended name:
CarboxypeptidaseUniRule annotation (EC:3.4.16.-UniRule annotation)
Gene namesi
Name:ctsa-2Imported
ORF Names:CELE_Y40D12A.2Imported, Y40D12A.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY40D12A.2; CE19621; WBGene00021503; ctsa-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 51123HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717UniRule annotationAdd
BLAST
Chaini18 – 512495CarboxypeptidaseUniRule annotationPRO_5004159816Add
BLAST

Proteomic databases

EPDiO76725.
PaxDbiO76725.
PRIDEiO76725.

Interactioni

Protein-protein interaction databases

DIPiDIP-27166N.
MINTiMINT-1085681.
STRINGi6239.Y40D12A.2.

Structurei

3D structure databases

ProteinModelPortaliO76725.
SMRiO76725. Positions 16-273, 326-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00790000123075.
HOGENOMiHOG000198295.
InParanoidiO76725.
KOiK13289.
OMAiPPSNDIQ.
OrthoDBiEOG7KQ21H.
PhylomeDBiO76725.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLLFITLF ALGSTAPADQ QITSLPNLTE PLRSKHYAGY LSISDVKQLF
60 70 80 90 100
YWYVESEESP ETAPVVLWLN GGPGCASMEG LFIEMGPFRV RNYGEEVNRN
110 120 130 140 150
PWTWNRIANI IYLDAPAGVG FSYYNTTKKV FTDDEVAQDN FNALKMWFAR
160 170 180 190 200
FPERKTNDFY IAGESYGGTY VPMLSARITK ANVDFPQFKG MLVGNGCVDD
210 220 230 240 250
QINFNTNIMY QYYHAVVDET QMQNVTQQCC NGTMDCDYYT ISQGNDTCGD
260 270 280 290 300
LVNQLSYSIY YTGYDPYFLY FACYLNPNLP YPPHEEIRKL QKNVLRNNLY
310 320 330 340 350
KKIIGESPVL KNKYFYPPSN DIQGQPDCAS HDDHFPYLNS PEVKKALRIP
360 370 380 390 400
DYVPKYEMCN MEIAENYQSQ YPTMKKFFDT VIDAKKHVAM FNGDADTLCN
410 420 430 440 450
YVENSQFIYK TLKKTVKTAM MPWNDPVQLP MAVGQVTEYD GITLISIKGG
460 470 480 490 500
GHFPAATEQK PKETFQMFQN YVKHQNYSTP VAFDKTFNLT STIIAVGSKL
510
FLSFCISIIL FL
Length:512
Mass (Da):58,567
Last modified:November 1, 1998 - v1
Checksum:i6D5EA079A0691A39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD64385.1.
PIRiT33463.
RefSeqiNP_498460.1. NM_066059.3.
UniGeneiCel.9815.

Genome annotation databases

EnsemblMetazoaiY40D12A.2; Y40D12A.2; WBGene00021503.
GeneIDi175938.
KEGGicel:CELE_Y40D12A.2.
UCSCiY40D12A.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD64385.1.
PIRiT33463.
RefSeqiNP_498460.1. NM_066059.3.
UniGeneiCel.9815.

3D structure databases

ProteinModelPortaliO76725.
SMRiO76725. Positions 16-273, 326-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-27166N.
MINTiMINT-1085681.
STRINGi6239.Y40D12A.2.

Protein family/group databases

ESTHERicaeel-Y40D12A.2. Carboxypeptidase_S10.
MEROPSiS10.A54.

Proteomic databases

EPDiO76725.
PaxDbiO76725.
PRIDEiO76725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY40D12A.2; Y40D12A.2; WBGene00021503.
GeneIDi175938.
KEGGicel:CELE_Y40D12A.2.
UCSCiY40D12A.2. c. elegans.

Organism-specific databases

CTDi175938.
WormBaseiY40D12A.2; CE19621; WBGene00021503; ctsa-2.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00790000123075.
HOGENOMiHOG000198295.
InParanoidiO76725.
KOiK13289.
OMAiPPSNDIQ.
OrthoDBiEOG7KQ21H.
PhylomeDBiO76725.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO76725_CAEEL
AccessioniPrimary (citable) accession number: O76725
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.