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Protein

Guanine nucleotide-binding protein alpha-11 subunit

Gene

gpa-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Mediates the transduction of food and serotonin signals, which modulates the avoidance response to the odorant octanol. Has a role in lifespan to promote longevity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41MagnesiumBy similarity1
Metal bindingi178MagnesiumBy similarity1
Binding sitei335GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41GTPBy similarity8
Nucleotide bindingi172 – 178GTPBy similarity7
Nucleotide bindingi197 – 201GTPBy similarity5
Nucleotide bindingi276 – 279GTPBy similarity4

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: GO_Central
  • G-protein coupled receptor binding Source: GO_Central
  • GTPase activity Source: WormBase
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • determination of adult lifespan Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: WormBase
  • serotonin receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-11 subunit
Gene namesi
Name:gpa-11
ORF Names:C16A11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC16A11.1a; CE20515; WBGene00001673; gpa-11.
C16A11.1b; CE45827; WBGene00001673; gpa-11.

Subcellular locationi

GO - Cellular componenti

  • heterotrimeric G-protein complex Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Slow to respond to octanol.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002036471 – 363Guanine nucleotide-binding protein alpha-11 subunitAdd BLAST363

Proteomic databases

PaxDbiO76584.

Expressioni

Tissue specificityi

Expressed in ADL and ASH neurons.1 Publication

Gene expression databases

BgeeiWBGene00001673.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C16A11.1b.

Structurei

3D structure databases

ProteinModelPortaliO76584.
SMRiO76584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038730.
InParanoidiO76584.
OMAiISAHEYK.
OrthoDBiEOG091G07V4.
PhylomeDBiO76584.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O76584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAADMARKN SLINRQLEKE KIDSKKMLKI LLLGGPECGK STIFKQMKII
60 70 80 90 100
HMNGFSDLDY VNFRYLIYSN IMQSMDQLLE AAEFFHFPPD DSPSIRRALN
110 120 130 140 150
HYKSYKVRYS TSEVELNREL ADSLSKLYNA EFIKSVLNRK NELKLLDSAV
160 170 180 190 200
YFLDDIDRIS AHEYKPTEMD VLRARVPTTG ITEIEFPFKQ ASLRMVDVGG
210 220 230 240 250
QRSEQRKWIH CFDNVNGVLF IAAISGYNLY DEDEENRKDD GTPTKTNRLR
260 270 280 290 300
YSMELFKRIA NHQCFSKKTA MILFLNKIDI FKEKIGKYPL TTCFKNYKGV
310 320 330 340 350
NAFEPACKYV TDRFSRLVSG DIQHEKPLYT HITNATDTRN IDRVFDSCMD
360
VIFKISMEKV GFM
Length:363
Mass (Da):42,232
Last modified:June 1, 2001 - v2
Checksum:i29A8F0F1F21579F6
GO
Isoform b (identifier: O76584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRIERDDSS...RVNVCGGTEM

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):59,561
Checksum:i6E2E5B09136A92E2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0439281M → MPRIERDDSSSGDTINSSAM EASTTDNGPLETTTDSNEPR PPPPLTNPTPRAPSVPPPMP PKRDLTPPRTCYDCGCFRNK ILAPLNSSTPGASGPAPPAN TTSSTNRTVSQQDKLAAGTP GPHSSTHNIESSAFATADIT LGFLLCGRLSFTTQVNNRVN VCGGTEM in isoform b. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008133 mRNA. Translation: AAG32086.1.
FO080260 Genomic DNA. Translation: CCD62416.1.
FO080260 Genomic DNA. Translation: CCD62417.1.
RefSeqiNP_001254088.1. NM_001267159.1. [O76584-2]
NP_001254089.1. NM_001267160.1. [O76584-1]
UniGeneiCel.14877.

Genome annotation databases

EnsemblMetazoaiC16A11.1a; C16A11.1a; WBGene00001673. [O76584-1]
GeneIDi173759.
KEGGicel:CELE_C16A11.1.
UCSCiC16A11.1. c. elegans. [O76584-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008133 mRNA. Translation: AAG32086.1.
FO080260 Genomic DNA. Translation: CCD62416.1.
FO080260 Genomic DNA. Translation: CCD62417.1.
RefSeqiNP_001254088.1. NM_001267159.1. [O76584-2]
NP_001254089.1. NM_001267160.1. [O76584-1]
UniGeneiCel.14877.

3D structure databases

ProteinModelPortaliO76584.
SMRiO76584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C16A11.1b.

Proteomic databases

PaxDbiO76584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC16A11.1a; C16A11.1a; WBGene00001673. [O76584-1]
GeneIDi173759.
KEGGicel:CELE_C16A11.1.
UCSCiC16A11.1. c. elegans. [O76584-1]

Organism-specific databases

CTDi173759.
WormBaseiC16A11.1a; CE20515; WBGene00001673; gpa-11.
C16A11.1b; CE45827; WBGene00001673; gpa-11.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038730.
InParanoidiO76584.
OMAiISAHEYK.
OrthoDBiEOG091G07V4.
PhylomeDBiO76584.

Miscellaneous databases

PROiO76584.

Gene expression databases

BgeeiWBGene00001673.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPA11_CAEEL
AccessioniPrimary (citable) accession number: O76584
Secondary accession number(s): F0IWT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.