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Protein

26S proteasome non-ATPase regulatory subunit 14

Gene

rpn-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi115Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi117Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi128Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-5689901 Metalloprotease DUBs
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiM67.A11

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 14 (EC:3.4.19.-)
Alternative name(s):
26S proteasome regulatory subunit rpn11
Gene namesi
Name:rpn-11
ORF Names:K07D4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK07D4.3 ; CE19527 ; WBGene00004467 ; rpn-11

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139541 – 31226S proteasome non-ATPase regulatory subunit 14Add BLAST312

Proteomic databases

EPDiO76577
PaxDbiO76577
PeptideAtlasiO76577
PRIDEiO76577

Expressioni

Gene expression databases

BgeeiWBGene00004467

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
rpn-8O617925EBI-324401,EBI-324407

Protein-protein interaction databases

BioGridi39100, 8 interactors
IntActiO76577, 8 interactors
STRINGi6239.K07D4.3.2

Structurei

3D structure databases

ProteinModelPortaliO76577
SMRiO76577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 168MPNPROSITE-ProRule annotationAdd BLAST136

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi115 – 128JAMM motifPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the peptidase M67A family. PSMD14 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1555 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00730000111116
HOGENOMiHOG000183690
InParanoidiO76577
KOiK03030
OMAiQTGRPET
OrthoDBiEOG091G0CMC
PhylomeDBiO76577

Family and domain databases

InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR024969 Rpn11/EIF3F_C
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

O76577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERFLRLGGL GGNLGTFGAN PQDSNQVDTS ETVYISSLAL LKMLKHGRAG
60 70 80 90 100
VPMEVMGLML GEFVDDYTVN VIDVFAMPQS GTGVSVEAVD PVFQAKMLDM
110 120 130 140 150
LKQTGRPEMV VGWYHSHPGF GCWLSGVDIN TQQSFEALSD RAVAVVVDPI
160 170 180 190 200
QSVKGKVVID AFRTINPQSM ALNQEPRQTT SNLGHLQKPS IQALIHGLNR
210 220 230 240 250
HYYSIPIAYR THDLEQKMLL NLNKLSWMDA VSVENYSKCG EQNKEHLKAM
260 270 280 290 300
LKLAKNYKKA LEDEKNMTDQ ELAIKNVGKM DPKRHIADEV SKMLNDNIVQ
310
SLAGMMATTS LQ
Length:312
Mass (Da):34,596
Last modified:November 1, 1998 - v1
Checksum:i3EEA4CFF998D69A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081599 Genomic DNA Translation: CCD72745.1
PIRiT33344
RefSeqiNP_494712.1, NM_062311.5
UniGeneiCel.4967

Genome annotation databases

EnsemblMetazoaiK07D4.3; K07D4.3; WBGene00004467
GeneIDi173744
KEGGicel:CELE_K07D4.3
UCSCiK07D4.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSDE_CAEEL
AccessioniPrimary (citable) accession number: O76577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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