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Protein

26S proteasome non-ATPase regulatory subunit 14

Gene

rpn-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi115 – 1151Zinc; catalyticBy similarity
Metal bindingi117 – 1171Zinc; catalyticBy similarity
Metal bindingi128 – 1281Zinc; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5668541. TNFR2 non-canonical NF-kB pathway.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiM67.A11.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 14 (EC:3.4.19.-)
Alternative name(s):
26S proteasome regulatory subunit rpn11
Gene namesi
Name:rpn-11
ORF Names:K07D4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK07D4.3; CE19527; WBGene00004467; rpn-11.

Subcellular locationi

GO - Cellular componenti

  • proteasome regulatory particle Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31231226S proteasome non-ATPase regulatory subunit 14PRO_0000213954Add
BLAST

Proteomic databases

EPDiO76577.
PaxDbiO76577.
PRIDEiO76577.

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
rpn-8O617925EBI-324401,EBI-324407

Protein-protein interaction databases

BioGridi39100. 8 interactions.
IntActiO76577. 8 interactions.
MINTiMINT-211040.
STRINGi6239.K07D4.3.2.

Structurei

3D structure databases

ProteinModelPortaliO76577.
SMRiO76577. Positions 29-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 138110MPNAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 12814JAMM motifAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M67A family. PSMD14 subfamily.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated

Phylogenomic databases

eggNOGiKOG1555. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00730000111116.
HOGENOMiHOG000183690.
InParanoidiO76577.
KOiK03030.
OMAiTQQSFES.
PhylomeDBiO76577.

Family and domain databases

InterProiIPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERFLRLGGL GGNLGTFGAN PQDSNQVDTS ETVYISSLAL LKMLKHGRAG
60 70 80 90 100
VPMEVMGLML GEFVDDYTVN VIDVFAMPQS GTGVSVEAVD PVFQAKMLDM
110 120 130 140 150
LKQTGRPEMV VGWYHSHPGF GCWLSGVDIN TQQSFEALSD RAVAVVVDPI
160 170 180 190 200
QSVKGKVVID AFRTINPQSM ALNQEPRQTT SNLGHLQKPS IQALIHGLNR
210 220 230 240 250
HYYSIPIAYR THDLEQKMLL NLNKLSWMDA VSVENYSKCG EQNKEHLKAM
260 270 280 290 300
LKLAKNYKKA LEDEKNMTDQ ELAIKNVGKM DPKRHIADEV SKMLNDNIVQ
310
SLAGMMATTS LQ
Length:312
Mass (Da):34,596
Last modified:November 1, 1998 - v1
Checksum:i3EEA4CFF998D69A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081599 Genomic DNA. Translation: CCD72745.1.
PIRiT33344.
RefSeqiNP_494712.1. NM_062311.5.
UniGeneiCel.4967.

Genome annotation databases

EnsemblMetazoaiK07D4.3; K07D4.3; WBGene00004467.
GeneIDi173744.
KEGGicel:CELE_K07D4.3.
UCSCiK07D4.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081599 Genomic DNA. Translation: CCD72745.1.
PIRiT33344.
RefSeqiNP_494712.1. NM_062311.5.
UniGeneiCel.4967.

3D structure databases

ProteinModelPortaliO76577.
SMRiO76577. Positions 29-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39100. 8 interactions.
IntActiO76577. 8 interactions.
MINTiMINT-211040.
STRINGi6239.K07D4.3.2.

Protein family/group databases

MEROPSiM67.A11.

Proteomic databases

EPDiO76577.
PaxDbiO76577.
PRIDEiO76577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK07D4.3; K07D4.3; WBGene00004467.
GeneIDi173744.
KEGGicel:CELE_K07D4.3.
UCSCiK07D4.3.1. c. elegans.

Organism-specific databases

CTDi173744.
WormBaseiK07D4.3; CE19527; WBGene00004467; rpn-11.

Phylogenomic databases

eggNOGiKOG1555. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00730000111116.
HOGENOMiHOG000183690.
InParanoidiO76577.
KOiK03030.
OMAiTQQSFES.
PhylomeDBiO76577.

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5668541. TNFR2 non-canonical NF-kB pathway.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO76577.

Family and domain databases

InterProiIPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSDE_CAEEL
AccessioniPrimary (citable) accession number: O76577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.