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Protein
Submitted name:

EPHeXin (Eph-interacting GEF) homolog

Gene

ephx-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-193648 NRAGE signals death through JNK
R-CEL-194840 Rho GTPase cycle
R-CEL-3928663 EPHA-mediated growth cone collapse
R-CEL-416482 G alpha (12/13) signalling events
SignaLinkiO76572

Names & Taxonomyi

Protein namesi
Submitted name:
EPHeXin (Eph-interacting GEF) homologImported
Gene namesi
Name:ephx-1Imported
ORF Names:CELE_K07D4.7Imported, K07D4.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK07D4.7b ; CE19531 ; WBGene00019487 ; ephx-1

Expressioni

Gene expression databases

BgeeiWBGene00019487
ExpressionAtlasiO76572 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO76572, 24 interactors

Structurei

3D structure databases

ProteinModelPortaliO76572
SMRiO76572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 360DHInterPro annotationAdd BLAST191
Domaini395 – 518PHInterPro annotationAdd BLAST124
Domaini529 – 590SH3InterPro annotationAdd BLAST62

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00550000074493
HOGENOMiHOG000007536
OrthoDBiEOG091G00V8

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

O76572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEKYVAR PAVGHLPLDD SWTPTSAEAI QDEPSPDEEE YKRQYTCRMV
60 70 80 90 100
PNEGPLYQHY MLEAVAVADD EVKIPLEEVK EEPVELPAAV VHEVVALKPA
110 120 130 140 150
TRRESSISSD SGRGADCSTT SASALTSNTS MRRDRLVGTS NFGSQRSLWC
160 170 180 190 200
ELPEVRAAGL LEKLDDECKL RQEAYFEVIT SEASYLRSLN VLITHFMASP
210 220 230 240 250
QMLGSKSALS VLSDSDRKHL FSNIFAVRDC SERLLCDLET RLEENLILDD
260 270 280 290 300
ICDILSDHFD KHFEVYIKYC SNQVYQDRTL RRLKTENPGF LSAVQRLEEN
310 320 330 340 350
KQCQGLDMRS FLMLPMQRVT RYPLLLYAIL DRITTTDDRY KTATDALTSS
360 370 380 390 400
NRVVRDCNEG ARRMERTEQL LDIDRRLIYK DADLKRIPLV SNSRYLVKKG
410 420 430 440 450
VLTQLVERRS SNILQSRQKA RTLHVFLFSD MIMITKKKLN GTFVCKDYAA
460 470 480 490 500
RRFVDMQPIE PDNPKIPLGA TSNLVGRPHL FLCTLMRNAR DKQTELLLSA
510 520 530 540 550
DSETDRERWL SAVRPPTSTN PEEKIYAEWD CPQALVVHAY QPSQADELQL
560 570 580 590 600
NIGDSLNILR KMPDGWLYGE RAGDGLGGWF PSSYVQAIIN DHTRANNYRQ
610 620 630 640
RLRIIQAASG WHGNASPSST RSGGMPLMDR LRRMSNPKTY FQSGTVGL
Length:648
Mass (Da):73,699
Last modified:November 1, 1998 - v1
Checksum:i65F7244CA13621DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD72750.1
PIRiT33339
RefSeqiNP_494707.1, NM_062306.3
UniGeneiCel.22684

Genome annotation databases

EnsemblMetazoaiK07D4.7b; K07D4.7b; WBGene00019487
GeneIDi173742
UCSCiK07D4.7a c. elegans

Similar proteinsi

Entry informationi

Entry nameiO76572_CAEEL
AccessioniPrimary (citable) accession number: O76572
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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