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Protein
Submitted name:

EPHeXin (Eph-interacting GEF) homolog

Gene

ephx-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-193648. NRAGE signals death through JNK.
R-CEL-194840. Rho GTPase cycle.
R-CEL-3928663. EPHA-mediated growth cone collapse.
R-CEL-416482. G alpha (12/13) signalling events.
SignaLinkiO76572.

Names & Taxonomyi

Protein namesi
Submitted name:
EPHeXin (Eph-interacting GEF) homologImported
Gene namesi
Name:ephx-1Imported
ORF Names:CELE_K07D4.7Imported, K07D4.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK07D4.7b; CE19531; WBGene00019487; ephx-1.

PTM / Processingi

Proteomic databases

EPDiO76572.
PaxDbiO76572.
PRIDEiO76572.

Expressioni

Gene expression databases

ExpressionAtlasiO76572. baseline.

Interactioni

Protein-protein interaction databases

IntActiO76572. 24 interactions.
STRINGi6239.K07D4.7a.

Structurei

3D structure databases

ProteinModelPortaliO76572.
SMRiO76572. Positions 160-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 360191DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini395 – 518124PHInterPro annotationAdd
BLAST
Domaini536 – 59055SH3InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains DH (DBL-homology) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
OrthoDBiEOG7SFHW2.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTEKYVAR PAVGHLPLDD SWTPTSAEAI QDEPSPDEEE YKRQYTCRMV
60 70 80 90 100
PNEGPLYQHY MLEAVAVADD EVKIPLEEVK EEPVELPAAV VHEVVALKPA
110 120 130 140 150
TRRESSISSD SGRGADCSTT SASALTSNTS MRRDRLVGTS NFGSQRSLWC
160 170 180 190 200
ELPEVRAAGL LEKLDDECKL RQEAYFEVIT SEASYLRSLN VLITHFMASP
210 220 230 240 250
QMLGSKSALS VLSDSDRKHL FSNIFAVRDC SERLLCDLET RLEENLILDD
260 270 280 290 300
ICDILSDHFD KHFEVYIKYC SNQVYQDRTL RRLKTENPGF LSAVQRLEEN
310 320 330 340 350
KQCQGLDMRS FLMLPMQRVT RYPLLLYAIL DRITTTDDRY KTATDALTSS
360 370 380 390 400
NRVVRDCNEG ARRMERTEQL LDIDRRLIYK DADLKRIPLV SNSRYLVKKG
410 420 430 440 450
VLTQLVERRS SNILQSRQKA RTLHVFLFSD MIMITKKKLN GTFVCKDYAA
460 470 480 490 500
RRFVDMQPIE PDNPKIPLGA TSNLVGRPHL FLCTLMRNAR DKQTELLLSA
510 520 530 540 550
DSETDRERWL SAVRPPTSTN PEEKIYAEWD CPQALVVHAY QPSQADELQL
560 570 580 590 600
NIGDSLNILR KMPDGWLYGE RAGDGLGGWF PSSYVQAIIN DHTRANNYRQ
610 620 630 640
RLRIIQAASG WHGNASPSST RSGGMPLMDR LRRMSNPKTY FQSGTVGL
Length:648
Mass (Da):73,699
Last modified:November 1, 1998 - v1
Checksum:i65F7244CA13621DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD72750.1.
PIRiT33339.
RefSeqiNP_494707.1. NM_062306.3.
UniGeneiCel.22684.

Genome annotation databases

EnsemblMetazoaiK07D4.7b; K07D4.7b; WBGene00019487.
GeneIDi173742.
UCSCiK07D4.7a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD72750.1.
PIRiT33339.
RefSeqiNP_494707.1. NM_062306.3.
UniGeneiCel.22684.

3D structure databases

ProteinModelPortaliO76572.
SMRiO76572. Positions 160-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO76572. 24 interactions.
STRINGi6239.K07D4.7a.

Proteomic databases

EPDiO76572.
PaxDbiO76572.
PRIDEiO76572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK07D4.7b; K07D4.7b; WBGene00019487.
GeneIDi173742.
UCSCiK07D4.7a. c. elegans.

Organism-specific databases

CTDi173742.
WormBaseiK07D4.7b; CE19531; WBGene00019487; ephx-1.

Phylogenomic databases

eggNOGiKOG3523. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00550000074493.
HOGENOMiHOG000007536.
OrthoDBiEOG7SFHW2.

Enzyme and pathway databases

ReactomeiR-CEL-193648. NRAGE signals death through JNK.
R-CEL-194840. Rho GTPase cycle.
R-CEL-3928663. EPHA-mediated growth cone collapse.
R-CEL-416482. G alpha (12/13) signalling events.
SignaLinkiO76572.

Miscellaneous databases

NextBioi880891.

Gene expression databases

ExpressionAtlasiO76572. baseline.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiO76572_CAEEL
AccessioniPrimary (citable) accession number: O76572
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.