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Protein

Acetylcholine receptor subunit alpha-type des-2

Gene

des-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha-type des-2
Gene namesi
Name:des-2
Synonyms:acr-4
ORF Names:T26H10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT26H10.1a; CE21208; WBGene00000955; des-2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 239ExtracellularSequence analysisAdd BLAST219
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 548CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: GO_Central
  • integral component of plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030273620 – 548Acetylcholine receptor subunit alpha-type des-2Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO76554.
PaxDbiO76554.

PTM databases

iPTMnetiO76554.

Expressioni

Gene expression databases

BgeeiWBGene00000955.
ExpressionAtlasiO76554. differential.

Interactioni

Subunit structurei

The functional receptor is a heteromer of deg-3 and des-2. Interacts with ric-3; which is required for proper receptor folding.3 Publications

Protein-protein interaction databases

IntActiO76554. 1 interactor.
STRINGi6239.T26H10.1.

Structurei

3D structure databases

ProteinModelPortaliO76554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000019549.
InParanoidiO76554.
PhylomeDBiO76554.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIIIQSLLL ATTASLCIAD TPVPTQIRLV HDLLDNYDKK AKPMWDNSKP
60 70 80 90 100
INVSFSMDLY QILELNEPQQ YILLNAWIIE RWFDEFLYWN PDDYENITEL
110 120 130 140 150
RLPYDSIWLP DTTLYNSLVM KDDDTRRLLN SKLTTDTHRR AALIELLYPT
160 170 180 190 200
IYKFSCLLDL RFFPFDVQVC TMTFSSWTYD QKGIDYFPYS DKIGTSNYLE
210 220 230 240 250
NEGWYILQTK IKRQEVKYAC CPNNYTLLQL TLYLRRKPLF YLVNLIIPTS
260 270 280 290 300
IITLIAIVGF FTTSSASGMR EEKVSLGITT LLSMSILMLM VSDQMPTTST
310 320 330 340 350
FIPLIGWFIL AMIIVISLGT VVSSVIIAIQ KRGSLGERMS KRALKFAKVL
360 370 380 390 400
AWFTCTSLPP HVEKEHMMEA FDAPTPLVEV RPLQLASVKE SVRNKWVSGA
410 420 430 440 450
RRATQRGNSG LALISDKSTD PLIHLSPTAH QPDESISPSA PPVPSSSPLP
460 470 480 490 500
PPLTPGPADD VVSVASELSS KFLTSRMRPK SQKDNTFAAM QSSIKANRQL
510 520 530 540
AVAEFEWFAT VVERTCFVIF VVAFLIITFG INFIGFIHWH QAGVEYGG
Length:548
Mass (Da):62,096
Last modified:November 1, 1998 - v1
Checksum:iA7495B31CFF5ACE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077307 mRNA. Translation: AAC98095.1.
Z74044, Z74039 Genomic DNA. Translation: CAA98550.1.
PIRiT23270.
RefSeqiNP_001256320.1. NM_001269391.1.
UniGeneiCel.19736.

Genome annotation databases

EnsemblMetazoaiT26H10.1a; T26H10.1a; WBGene00000955.
GeneIDi179574.
KEGGicel:CELE_T26H10.1.
UCSCiT26H10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077307 mRNA. Translation: AAC98095.1.
Z74044, Z74039 Genomic DNA. Translation: CAA98550.1.
PIRiT23270.
RefSeqiNP_001256320.1. NM_001269391.1.
UniGeneiCel.19736.

3D structure databases

ProteinModelPortaliO76554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO76554. 1 interactor.
STRINGi6239.T26H10.1.

PTM databases

iPTMnetiO76554.

Proteomic databases

EPDiO76554.
PaxDbiO76554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT26H10.1a; T26H10.1a; WBGene00000955.
GeneIDi179574.
KEGGicel:CELE_T26H10.1.
UCSCiT26H10.1. c. elegans.

Organism-specific databases

CTDi179574.
WormBaseiT26H10.1a; CE21208; WBGene00000955; des-2.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000019549.
InParanoidiO76554.
PhylomeDBiO76554.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Miscellaneous databases

PROiO76554.

Gene expression databases

BgeeiWBGene00000955.
ExpressionAtlasiO76554. differential.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACH4_CAEEL
AccessioniPrimary (citable) accession number: O76554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.