O76513 (O76513_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cyclin H EMBL AAF51784.1
EC=2.7.1.- EMBL AAF51784.1

Submitted name:
Cyclin H homolog EMBL AAC26868.1

Gene names

Name:	CycH EMBL AAF51784.1 FlyBase FBgn0022936
ORF Names:	CG7405 FlyBase FBgn0022936, Dmel_CG7405 EMBL AAF51784.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the cyclin family. RuleBase RU000383

Ontologies

Keywords
Molecular function	Cyclin SAAS SAAS006671 RuleBase RU000383 EMBL AAC26868.1 Transferase EMBL AAF51784.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	holo TFIIH complex Inferred from electronic annotation. Source: InterPro
Molecular function	protein kinase binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O76513 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: F8AF2FCD1877DAD9	FASTA	324	37,777
	10 20 30 40 50 60 MYPVSSQKRS WTFANEGQLM EFRVEQNSKY IESHEEEAQG RDLNEHFLTS AEERLLLKQY 70 80 90 100 110 120 EIYLFDFCRR FEPTMPKCVV GTAFHYFKRF YLNNSPMDYH PKEILATCVF VACKVEEFNV 130 140 150 160 170 180 SINQFVNNIK GDRNKATDIV LSNELLLIGQ LNYYLTIHNP FRPIEGFLID IKTRSNMQNP 190 200 210 220 230 240 DRLRPHIDSF IDSTYYSDAC LLHTPSQIAL AAVLHAASRE QENLDSYVTD LLFVSAREKL 250 260 270 280 290 300 PGLIDAVRKI RIMVKQYQQP DREKVKAIEK KLDKCRNQAN NPDSELYKER LRRLYTDEDD 310 320 MPAEDASFHI ADVSSDTSAM NISQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	"Drosophila cyclin H homolog." Larochelle S., Suter B. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon R EMBL AAC26868.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF074334 mRNA. Translation: AAC26868.1. AE014296 Genomic DNA. Translation: AAF51784.1.
RefSeq	NP_524207.1. NM_079483.2.
UniGene	Dm.2503.
3D structure databases
HSSP	HSSP built from PDB template 1JKW based on UniProtKB P51946.
ProteinModelPortal	O76513.
SMR	O76513. Positions 11-281.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76513. 1 interaction.
MINT	MINT-927578.
STRING	O76513.
Proteomic databases
PRIDE	O76513.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0078439; FBpp0078093; FBgn0022936.
GeneID	40429.
KEGG	dme:Dmel_CG7405.
UCSC	CG7405-RA. d. melanogaster.
Organism-specific databases
CTD	40429.
FlyBase	FBgn0022936. CycH.
Phylogenomic databases
InParanoid	O76513.
OMA	ICKYYEK.
PhylomeDB	O76513.
Gene expression databases
ArrayExpress	O76513.
Bgee	O76513.
Family and domain databases
InterPro	IPR013763. Cyclin-like. IPR023598. Cyclin_C/H. IPR015429. Cyclin_C/H/T/L. IPR015432. Cyclin_H. IPR006671. Cyclin_N. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 2 hits.
KO	K06634.
PANTHER	PTHR10026:SF8. CycH. 1 hit. PTHR10026. Trans_reg_cyclin. 1 hit.
Pfam	PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF028758. PIRSF028758. 1 hit.
SMART	SM00385. CYCLIN. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
TIGRFAMs	TIGR00569. Ccl1. 1 hit.
ProtoNet	Search...
Other
NextBio	818731.

Entry information

Entry name

O76513_DROME

Accession

Primary (citable) accession number: O76513

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)