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O76483 (GSTT7_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase D7

EC=2.5.1.18
Alternative name(s):
Aggst1-7
GST class-theta
Gst1-beta
Gene names
Name:GstD7
Synonyms:GST1-7
ORF Names:AGAP004163
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P30711

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB Q93113

Subunit structure

Homodimer By similarity. UniProtKB P30711

Sequence similarities

Belongs to the GST superfamily. Theta family. UniProtKB Q93113

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Glutathione S-transferase D7
PRO_0000284749

Regions

Domain1 – 8282GST N-terminal
Domain88 – 207120GST C-terminal
Region52 – 543Glutathione binding By similarity
Region66 – 683Glutathione binding By similarity

Sites

Binding site111Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
O76483 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 60060000B2ED836C

FASTA21824,998
        10         20         30         40         50         60 
MTPVLYYLPP SPPCRSVLLL AKMIGVELEL KALNVMEGEQ LKPDFVELNP QHCIPTLDDH 

        70         80         90        100        110        120 
GLVLWESRVI LAYLVSAYGK DENLYPKDFR SRAIVDQRLH FDLGTLYQRV VDYYFPTIQL 

       130        140        150        160        170        180 
GAHLDQTKKA KLAEALGWFE AMLKQYQWSA ANHFTIADIA LCVTVSQIEA FQFDLHPYPR 

       190        200        210 
VRAWLQKCKD ELQGHGYKEI NETGAETLAG LFRSKLKQ 

« Hide

References

« Hide 'large scale' references
[1]"The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
Ranson H., Collins F.H., Hemingway J.
Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ZAN/U.
[2]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.
[3]"Analysis of a GST promoter in the malaria mosquito Anopheles gambiae."
Ortelli F., Hemingway J.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
Strain: Zands.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF071161 mRNA. Translation: AAC79997.1.
AAAB01008880 Genomic DNA. Translation: EAL40657.3.
AY063775 Genomic DNA. Translation: AAL59657.1.

3D structure databases

ProteinModelPortalO76483.
SMRO76483. Positions 2-215.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP004163-RB; AGAP004163-PB; AGAP004163.
KEGGaga:AgaP_AGAP004163.
VectorBaseAGAP004162. Anopheles gambiae.
AGAP004163. Anopheles gambiae.

Organism-specific databases

CTD1273987.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000125741.
InParanoidO76483.
KOK00799.
OrthoDBEOG72VH7S.
PhylomeDBO76483.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT7_ANOGA
AccessionPrimary (citable) accession number: O76483
Secondary accession number(s): A0NDD6, Q7QB62, Q8WQM2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families