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O76483

- GSTT7_ANOGA

UniProt

O76483 - GSTT7_ANOGA

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Protein

Glutathione S-transferase D7

Gene

GstD7

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase D7 (EC:2.5.1.18)
Alternative name(s):
Aggst1-7
GST class-theta
Gst1-beta
Gene namesi
Name:GstD71 Publication
Synonyms:GST1-7Imported
ORF Names:AGAP004163
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2R

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase D7PRO_0000284749Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO76483.
SMRiO76483. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282GST N-terminalAdd
BLAST
Domaini88 – 207120GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Glutathione bindingBy similarity
Regioni66 – 683Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.By similarity
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125741.
InParanoidiO76483.
KOiK00799.
OrthoDBiEOG72VH7S.
PhylomeDBiO76483.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76483-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPVLYYLPP SPPCRSVLLL AKMIGVELEL KALNVMEGEQ LKPDFVELNP
60 70 80 90 100
QHCIPTLDDH GLVLWESRVI LAYLVSAYGK DENLYPKDFR SRAIVDQRLH
110 120 130 140 150
FDLGTLYQRV VDYYFPTIQL GAHLDQTKKA KLAEALGWFE AMLKQYQWSA
160 170 180 190 200
ANHFTIADIA LCVTVSQIEA FQFDLHPYPR VRAWLQKCKD ELQGHGYKEI
210
NETGAETLAG LFRSKLKQ
Length:218
Mass (Da):24,998
Last modified:November 1, 1998 - v1
Checksum:i60060000B2ED836C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071161 mRNA. Translation: AAC79997.1.
AAAB01008880 Genomic DNA. Translation: EAL40657.3.
AY063775 Genomic DNA. Translation: AAL59657.1.
RefSeqiXP_562676.3. XM_562676.3.

Genome annotation databases

EnsemblMetazoaiAGAP004163-RB; AGAP004163-PB; AGAP004163.
GeneIDi1273987.
KEGGiaga:AgaP_AGAP004163.
VectorBaseiAGAP004162. Anopheles gambiae.
AGAP004163. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071161 mRNA. Translation: AAC79997.1 .
AAAB01008880 Genomic DNA. Translation: EAL40657.3 .
AY063775 Genomic DNA. Translation: AAL59657.1 .
RefSeqi XP_562676.3. XM_562676.3.

3D structure databases

ProteinModelPortali O76483.
SMRi O76483. Positions 2-215.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP004163-RB ; AGAP004163-PB ; AGAP004163 .
GeneIDi 1273987.
KEGGi aga:AgaP_AGAP004163.
VectorBasei AGAP004162. Anopheles gambiae.
AGAP004163. Anopheles gambiae.

Organism-specific databases

CTDi 1273987.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125741.
InParanoidi O76483.
KOi K00799.
OrthoDBi EOG72VH7S.
PhylomeDBi O76483.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
    Ranson H., Collins F.H., Hemingway J.
    Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ZAN/UImported.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.
  3. "Analysis of a GST promoter in the malaria mosquito Anopheles gambiae."
    Ortelli F., Hemingway J.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
    Strain: ZandsImported.

Entry informationi

Entry nameiGSTT7_ANOGA
AccessioniPrimary (citable) accession number: O76483
Secondary accession number(s): A0NDD6, Q7QB62, Q8WQM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3