O76483 (GSTT7_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase D7
EC=2.5.1.18

Alternative name(s):
Aggst1-7
GST class-theta
Gst1-beta

Gene names

Name:	GstD7
Synonyms:	GST1-7
ORF Names:	AGAP004163

Organism

Anopheles gambiae (African malaria mosquito) [Reference proteome]

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P30711
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB Q93113
Subunit structure	Homodimer By similarity. UniProtKB P30711
Sequence similarities	Belongs to the GST superfamily. Theta family. UniProtKB Q93113 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Glutathione S-transferase D7		PRO_0000284749
Regions
	Domain	1 – 82	82	GST N-terminal
	Domain	88 – 207	120	GST C-terminal
	Region	52 – 54	3	Glutathione binding By similarity
	Region	66 – 68	3	Glutathione binding By similarity
Sites
	Binding site	11	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	O76483 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 60060000B2ED836C	FASTA	218	24,998
	10 20 30 40 50 60 MTPVLYYLPP SPPCRSVLLL AKMIGVELEL KALNVMEGEQ LKPDFVELNP QHCIPTLDDH 70 80 90 100 110 120 GLVLWESRVI LAYLVSAYGK DENLYPKDFR SRAIVDQRLH FDLGTLYQRV VDYYFPTIQL 130 140 150 160 170 180 GAHLDQTKKA KLAEALGWFE AMLKQYQWSA ANHFTIADIA LCVTVSQIEA FQFDLHPYPR 190 200 210 VRAWLQKCKD ELQGHGYKEI NETGAETLAG LFRSKLKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family." Ranson H., Collins F.H., Hemingway J. Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ZAN/U.
[2]	"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.
[3]	"Analysis of a GST promoter in the malaria mosquito Anopheles gambiae." Ortelli F., Hemingway J. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27. Strain: Zands.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071161 mRNA. Translation: AAC79997.1. AAAB01008880 Genomic DNA. Translation: EAL40657.3. AY063775 Genomic DNA. Translation: AAL59657.1.
RefSeq	XP_562676.3. XM_562676.3.
3D structure databases
HSSP	HSSP built from PDB template 1PN9 based on UniProtKB Q93113.
ProteinModelPortal	O76483.
SMR	O76483. Positions 2-215.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AGAP004163-RB; AGAP004163-PB; AGAP004163.
GeneID	1273987.
KEGG	aga:AgaP_AGAP004163.
VectorBase	AGAP004162. Anopheles gambiae. AGAP004163. Anopheles gambiae.
Organism-specific databases
CTD	1273987.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125741.
InParanoid	O76483.
KO	K00799.
OrthoDB	EOG4Z8WCJ.
PhylomeDB	O76483.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTT7_ANOGA

Accession

Primary (citable) accession number: O76483
Secondary accession number(s): A0NDD6, Q7QB62, Q8WQM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)