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Protein

Glutathione S-transferase D7

Gene

GstD7

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase D7 (EC:2.5.1.18)
Alternative name(s):
Aggst1-7
GST class-theta
Gst1-beta
Gene namesi
Name:GstD71 Publication
Synonyms:GST1-7Imported
ORF Names:AGAP004163
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 2R, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847491 – 218Glutathione S-transferase D7Add BLAST218

Proteomic databases

PaxDbiO76483.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7165.AGAP004163-PB.

Structurei

3D structure databases

ProteinModelPortaliO76483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82GST N-terminalAdd BLAST82
Domaini88 – 207GST C-terminalAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Glutathione bindingBy similarity3
Regioni66 – 68Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.By similarity
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125741.
InParanoidiO76483.
KOiK00799.
OrthoDBiEOG091G0LZ8.
PhylomeDBiO76483.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPVLYYLPP SPPCRSVLLL AKMIGVELEL KALNVMEGEQ LKPDFVELNP
60 70 80 90 100
QHCIPTLDDH GLVLWESRVI LAYLVSAYGK DENLYPKDFR SRAIVDQRLH
110 120 130 140 150
FDLGTLYQRV VDYYFPTIQL GAHLDQTKKA KLAEALGWFE AMLKQYQWSA
160 170 180 190 200
ANHFTIADIA LCVTVSQIEA FQFDLHPYPR VRAWLQKCKD ELQGHGYKEI
210
NETGAETLAG LFRSKLKQ
Length:218
Mass (Da):24,998
Last modified:November 1, 1998 - v1
Checksum:i60060000B2ED836C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071161 mRNA. Translation: AAC79997.1.
AAAB01008880 Genomic DNA. Translation: EAL40657.3.
AY063775 Genomic DNA. Translation: AAL59657.1.
RefSeqiXP_562676.3. XM_562676.3.

Genome annotation databases

EnsemblMetazoaiAGAP004163-RB; AGAP004163-PB; AGAP004163.
GeneIDi1273987.
KEGGiaga:AgaP_AGAP004163.
VectorBaseiAGAP004163-RB; AGAP004163-PB; AGAP004163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071161 mRNA. Translation: AAC79997.1.
AAAB01008880 Genomic DNA. Translation: EAL40657.3.
AY063775 Genomic DNA. Translation: AAL59657.1.
RefSeqiXP_562676.3. XM_562676.3.

3D structure databases

ProteinModelPortaliO76483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP004163-PB.

Proteomic databases

PaxDbiO76483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP004163-RB; AGAP004163-PB; AGAP004163.
GeneIDi1273987.
KEGGiaga:AgaP_AGAP004163.
VectorBaseiAGAP004163-RB; AGAP004163-PB; AGAP004163.

Organism-specific databases

CTDi1273987.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125741.
InParanoidiO76483.
KOiK00799.
OrthoDBiEOG091G0LZ8.
PhylomeDBiO76483.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT7_ANOGA
AccessioniPrimary (citable) accession number: O76483
Secondary accession number(s): A0NDD6, Q7QB62, Q8WQM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.