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O76483

- GSTT7_ANOGA

UniProt

O76483 - GSTT7_ANOGA

Protein

Glutathione S-transferase D7

Gene

GstD7

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB

    GO - Biological processi

    1. glutathione metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase D7 (EC:2.5.1.18)
    Alternative name(s):
    Aggst1-7
    GST class-theta
    Gst1-beta
    Gene namesi
    Name:GstD71 Publication
    Synonyms:GST1-7Imported
    ORF Names:AGAP004163
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2R

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Glutathione S-transferase D7PRO_0000284749Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO76483.
    SMRiO76483. Positions 2-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282GST N-terminalAdd
    BLAST
    Domaini88 – 207120GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 543Glutathione bindingBy similarity
    Regioni66 – 683Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.By similarity
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125741.
    InParanoidiO76483.
    KOiK00799.
    OrthoDBiEOG72VH7S.
    PhylomeDBiO76483.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPVLYYLPP SPPCRSVLLL AKMIGVELEL KALNVMEGEQ LKPDFVELNP    50
    QHCIPTLDDH GLVLWESRVI LAYLVSAYGK DENLYPKDFR SRAIVDQRLH 100
    FDLGTLYQRV VDYYFPTIQL GAHLDQTKKA KLAEALGWFE AMLKQYQWSA 150
    ANHFTIADIA LCVTVSQIEA FQFDLHPYPR VRAWLQKCKD ELQGHGYKEI 200
    NETGAETLAG LFRSKLKQ 218
    Length:218
    Mass (Da):24,998
    Last modified:November 1, 1998 - v1
    Checksum:i60060000B2ED836C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071161 mRNA. Translation: AAC79997.1.
    AAAB01008880 Genomic DNA. Translation: EAL40657.3.
    AY063775 Genomic DNA. Translation: AAL59657.1.
    RefSeqiXP_562676.3. XM_562676.3.

    Genome annotation databases

    EnsemblMetazoaiAGAP004163-RB; AGAP004163-PB; AGAP004163.
    GeneIDi1273987.
    KEGGiaga:AgaP_AGAP004163.
    VectorBaseiAGAP004162. Anopheles gambiae.
    AGAP004163. Anopheles gambiae.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071161 mRNA. Translation: AAC79997.1 .
    AAAB01008880 Genomic DNA. Translation: EAL40657.3 .
    AY063775 Genomic DNA. Translation: AAL59657.1 .
    RefSeqi XP_562676.3. XM_562676.3.

    3D structure databases

    ProteinModelPortali O76483.
    SMRi O76483. Positions 2-215.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP004163-RB ; AGAP004163-PB ; AGAP004163 .
    GeneIDi 1273987.
    KEGGi aga:AgaP_AGAP004163.
    VectorBasei AGAP004162. Anopheles gambiae.
    AGAP004163. Anopheles gambiae.

    Organism-specific databases

    CTDi 1273987.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125741.
    InParanoidi O76483.
    KOi K00799.
    OrthoDBi EOG72VH7S.
    PhylomeDBi O76483.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of alternative mRNA splicing in generating heterogeneity within the Anopheles gambiae class I glutathione S-transferase family."
      Ranson H., Collins F.H., Hemingway J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14284-14289(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ZAN/UImported.
    2. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PEST.
    3. "Analysis of a GST promoter in the malaria mosquito Anopheles gambiae."
      Ortelli F., Hemingway J.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
      Strain: ZandsImported.

    Entry informationi

    Entry nameiGSTT7_ANOGA
    AccessioniPrimary (citable) accession number: O76483
    Secondary accession number(s): A0NDD6, Q7QB62, Q8WQM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3