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Protein
Submitted name:

Ornithine carbamoyltransferase

Gene

OTC

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Ornithine carbamoyltransferaseImported
Gene namesi
Name:OTCImported
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi166 ↔ 227Combined sources
Disulfide bondi181 ↔ 188Combined sources

Interactioni

Protein-protein interaction databases

STRINGi184922.XP_001709979.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GRFX-ray2.00A1-327[»]
ProteinModelPortaliO76458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76458.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 146140OTCace_NInterPro annotationAdd
BLAST
Domaini159 – 318160OTCaceInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1504. Eukaryota.
COG0078. LUCA.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.

Sequencei

Sequence statusi: Complete.

O76458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFKQTRHLL TISALCPKEL AYLIDRALDM KKNPAKYTAR AANKTLLAFF
60 70 80 90 100
AKPSLRTRVS LETAMTRLGG HAIYYELGAN SNVGGKETVQ DTAEVFSRMV
110 120 130 140 150
DICTARLATK EMMREMAQHA SVPCINALDD FGHPLQMVCD FMTIKEKFTA
160 170 180 190 200
AGEFSNGFKG IKFAYCGDSM NNVTYDLMRG CALLGMECHV CCPDHKDFKP
210 220 230 240 250
IKEVIDECEE IIAKHGTGGS IKIFHDCKKG CEGVDVVYTD SWMSYHITKE
260 270 280 290 300
QKEARLKVLT PFQVDDAVMA VTSKRSIFMN CLPATRGEEQ TASVIDGPKS
310 320
VCYDEAGNRL HSAMAVLDFF LHDCKME
Length:327
Mass (Da):36,437
Last modified:November 1, 1998 - v1
Checksum:iC5FB3D691A30ABF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069576 Genomic DNA. Translation: AAC28939.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069576 Genomic DNA. Translation: AAC28939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GRFX-ray2.00A1-327[»]
ProteinModelPortaliO76458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi184922.XP_001709979.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1504. Eukaryota.
COG0078. LUCA.

Miscellaneous databases

EvolutionaryTraceiO76458.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Ornithine carbamoyltransferase gene from Giardia intestinalis."
    Sekyere E.O., Stewart T.S., Edwards M.R., Schofield P.J., Knodler L.A.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wb C6Imported.
  2. "X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia."
    Galkin A., Kulakova L., Wu R., Gong M., Dunaway-Mariano D., Herzberg O.
    Proteins 76:1049-1053(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS), DISULFIDE BONDS.

Entry informationi

Entry nameiO76458_GIAIN
AccessioniPrimary (citable) accession number: O76458
Secondary accession number(s): A8B2I4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.