O76387 (PTH2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable peptidyl-tRNA hydrolase 2
Short name=PTH 2
EC=3.1.1.29

Gene names

ORF Names:

C24G6.8

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
Sequence similarities	Belongs to the PTH2 family. Contains 1 UBA domain.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Probable peptidyl-tRNA hydrolase 2		PRO_0000120283
Regions
	Domain	128 – 169	42	UBA

Sequences

	Sequence		Length	Mass (Da)
	O76387 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 20E4FA3D52B4EFB0	FASTA	316	33,689
	10 20 30 40 50 60 MSENIPDIDP NELLPNAPGQ HQDLGVDNPP EPDNASIRAE RGSPTPSSVT VDNAPSLPDR 70 80 90 100 110 120 SFSHLPINDP FSGEIPEVPI PSSAISISSQ ALSDPVPTPS DTSRPGILRN DEQGSTSSHP 130 140 150 160 170 180 VDPQEPNEVN NEYLAHLLDL GFDEYTAVLA LKRTNSAGVE QAVAWIVERS NESDFDEDSS 190 200 210 220 230 240 SSENEADEEM GAVQSVAGRT HKMVLVANMS LKMGTGKIAA QVGHATLGVY RQAMNSENGQ 250 260 270 280 290 300 NAIAAWTRHG QVKIVVKGQS TEQLMDLCKV AKDAGCYYYL VQDAGYTQIP AGSRTVLGIF 310 GTVEQVDSVT GGLKLL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080610 Genomic DNA. Translation: CCD65135.1.
PIR	T33180.
RefSeq	NP_504461.1. NM_072060.3.
UniGene	Cel.6598.
3D structure databases
ProteinModelPortal	O76387.
SMR	O76387. Positions 128-169, 200-316.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76387. 1 interaction.
STRING	O76387.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C24G6.8.1; C24G6.8.1; C24G6.8. C24G6.8.2; C24G6.8.2; C24G6.8. C24G6.8.3; C24G6.8.3; C24G6.8. C24G6.8.4; C24G6.8.4; C24G6.8.
GeneID	178937.
KEGG	cel:C24G6.8.
UCSC	C24G6.8.1. c. elegans.
Organism-specific databases
CTD	178937.
WormBase	C24G6.8; CE17464; WBGene00016062.
Phylogenomic databases
eggNOG	meNOG18568.
GeneTree	EMGT00050000005884.
HOGENOM	HBG526257.
InParanoid	O76387.
OMA	NASIRAE.
PhylomeDB	O76387.
Gene expression databases
ArrayExpress	O76387.
Family and domain databases
InterPro	IPR023476. Pep_tRNA_hydro_II_dom. IPR002833. Pep_tRNA_hydro_PTH2. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. [Graphical view]
Gene3D	G3DSA:3.40.1490.10. G3DSA:3.40.1490.10. 1 hit.
KO	K04794.
PANTHER	PTHR12649:SF6. PTHR12649:SF6. 1 hit.
Pfam	PF01981. PTH2. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
SUPFAM	SSF102462. SSF102462. 1 hit. SSF46934. UBA_like. 1 hit.
TIGRFAMs	TIGR00283. Arch_pth2. 1 hit.
PROSITE	PS50030. UBA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	903196.

Entry information

Entry name

PTH2_CAEEL

Accession

Primary (citable) accession number: O76387

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project