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Protein

Probable peptidyl-tRNA hydrolase 2

Gene

C24G6.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-tRNA hydrolase 2 (EC:3.1.1.29)
Short name:
PTH 2
Gene namesi
ORF Names:C24G6.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC24G6.8; CE17464; WBGene00016062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Probable peptidyl-tRNA hydrolase 2PRO_0000120283Add
BLAST

Proteomic databases

EPDiO76387.
PaxDbiO76387.

PTM databases

iPTMnetiO76387.

Interactioni

Protein-protein interaction databases

DIPiDIP-59880N.
IntActiO76387. 1 interaction.
STRINGi6239.C24G6.8.4.

Structurei

3D structure databases

ProteinModelPortaliO76387.
SMRiO76387. Positions 201-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 16942UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PTH2 family.Curated
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3282. Eukaryota.
COG1990. LUCA.
GeneTreeiENSGT00390000015991.
HOGENOMiHOG000018975.
InParanoidiO76387.
KOiK04794.
OMAiNNEYLAH.
PhylomeDBiO76387.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
SSF46934. SSF46934. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENIPDIDP NELLPNAPGQ HQDLGVDNPP EPDNASIRAE RGSPTPSSVT
60 70 80 90 100
VDNAPSLPDR SFSHLPINDP FSGEIPEVPI PSSAISISSQ ALSDPVPTPS
110 120 130 140 150
DTSRPGILRN DEQGSTSSHP VDPQEPNEVN NEYLAHLLDL GFDEYTAVLA
160 170 180 190 200
LKRTNSAGVE QAVAWIVERS NESDFDEDSS SSENEADEEM GAVQSVAGRT
210 220 230 240 250
HKMVLVANMS LKMGTGKIAA QVGHATLGVY RQAMNSENGQ NAIAAWTRHG
260 270 280 290 300
QVKIVVKGQS TEQLMDLCKV AKDAGCYYYL VQDAGYTQIP AGSRTVLGIF
310
GTVEQVDSVT GGLKLL
Length:316
Mass (Da):33,689
Last modified:November 1, 1998 - v1
Checksum:i20E4FA3D52B4EFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080610 Genomic DNA. Translation: CCD65135.1.
PIRiT33180.
RefSeqiNP_504461.1. NM_072060.4.
UniGeneiCel.6598.

Genome annotation databases

EnsemblMetazoaiC24G6.8.1; C24G6.8.1; WBGene00016062.
C24G6.8.2; C24G6.8.2; WBGene00016062.
C24G6.8.3; C24G6.8.3; WBGene00016062.
C24G6.8.4; C24G6.8.4; WBGene00016062.
GeneIDi178937.
KEGGicel:CELE_C24G6.8.
UCSCiC24G6.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080610 Genomic DNA. Translation: CCD65135.1.
PIRiT33180.
RefSeqiNP_504461.1. NM_072060.4.
UniGeneiCel.6598.

3D structure databases

ProteinModelPortaliO76387.
SMRiO76387. Positions 201-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59880N.
IntActiO76387. 1 interaction.
STRINGi6239.C24G6.8.4.

PTM databases

iPTMnetiO76387.

Proteomic databases

EPDiO76387.
PaxDbiO76387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC24G6.8.1; C24G6.8.1; WBGene00016062.
C24G6.8.2; C24G6.8.2; WBGene00016062.
C24G6.8.3; C24G6.8.3; WBGene00016062.
C24G6.8.4; C24G6.8.4; WBGene00016062.
GeneIDi178937.
KEGGicel:CELE_C24G6.8.
UCSCiC24G6.8.1. c. elegans.

Organism-specific databases

CTDi178937.
WormBaseiC24G6.8; CE17464; WBGene00016062.

Phylogenomic databases

eggNOGiKOG3282. Eukaryota.
COG1990. LUCA.
GeneTreeiENSGT00390000015991.
HOGENOMiHOG000018975.
InParanoidiO76387.
KOiK04794.
OMAiNNEYLAH.
PhylomeDBiO76387.

Miscellaneous databases

PROiO76387.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
IPR015940. UBA.
IPR009060. UBA-like.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
SSF46934. SSF46934. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPTH2_CAEEL
AccessioniPrimary (citable) accession number: O76387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.