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Protein

Telomerase reverse transcriptase

Gene

TERT

Organism
Oxytricha trifallax (Sterkiella histriomuscorum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi708 – 7081Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi886 – 8861Magnesium; catalyticPROSITE-ProRule annotation
Metal bindingi887 – 8871Magnesium; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase reverse transcriptase (EC:2.7.7.49)
Alternative name(s):
Telomerase catalytic subunit
Telomerase subunit P133
Gene namesi
Name:TERT
OrganismiOxytricha trifallax (Sterkiella histriomuscorum)
Taxonomic identifieri94289 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataSpirotricheaStichotrichiaSporadotrichidaOxytrichidaeStylonychinaeSterkiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11321132Telomerase reverse transcriptasePRO_0000054928Add
BLAST

Proteomic databases

PRIDEiO76332.

Structurei

3D structure databases

ProteinModelPortaliO76332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini602 – 956355Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKPVQSK LNIGNPTIPV TSNRSTAPKP VPGQPQFVNQ EKKQQSQNTT
60 70 80 90 100
TGAFRSNQNN ANSGGNGNFE LDDLHLALKS CNEIGSAKTL FCFFMELQKI
110 120 130 140 150
NDKIPSKKNT ELIKNDPQFQ YFCHNTILCT EQSYDEKTIE KLAKLEYKLE
160 170 180 190 200
YKNSYIDMIS KVIKELLIEN KLNKLQTFGY KLVNNEFGNQ NHLGMMQQNQ
210 220 230 240 250
DSSHNSNFMV KCDYINLNKQ CMITKNWEKV YFYLGDHLFM HIYKEYMIFL
260 270 280 290 300
KTRDESLVQI SGTNIFCYLN EKLGRLQAAF YEGPNKNAAN SAAQGSNPEA
310 320 330 340 350
NDLISAEQRK INTAIVMKKT HKYNIKAADE SYLTNQEKGF WDDQIKRNRL
360 370 380 390 400
FYCAHQNRFF QKHILNSKTL SQQQIRDNIY KEVFGFNRVR AELKGKVMSI
410 420 430 440 450
IEQVIVNQKK FDFKYYLSKN CPLPENWKNL KKSFLEDAAV SGELRGQVFR
460 470 480 490 500
QLFEYQQDQR QISNFLTEFV ANVFPKNFLE GKNKKIFNKK MLQFVKFNRF
510 520 530 540 550
ESFTKISLLN KFRVNEVSWL SFKCKDENKK FFMNENEHVF FKVLKWVFED
560 570 580 590 600
LAITLMRCYF YSTEKAKEYQ RIFYYRKNIW NMIMRLSIDD LLKQNLKQVE
610 620 630 640 650
KKEMRIFCES QNFAPGKLRL IPKGDTFRPI MTFNRKIPNQ VGKFQSRMTT
660 670 680 690 700
NNKLQTAHMM LKNLKSKMFK HSFGFAVFNY DDIMKRYENF VQKWKQINSP
710 720 730 740 750
KLYFVAMDIE KCYDNVDCER VVNFLQKSDL MDKEYFILNT FVLKRKNNII
760 770 780 790 800
VERSNFRKLP IKQYFRYKFQ KIGIDGSSYP TLFEILEDEF NDLNMKRTII
810 820 830 840 850
VEQEQRKKFP KNDLLQPVLK ICQNNYVTFN KKQYKQMKGI PQGLCVSYIL
860 870 880 890 900
SSFYYANLEE NALQFLRKES MDPEKPEINL LMRLTDDYLL MTTEKNNAML
910 920 930 940 950
FIEKLYQLSL GNFFKFHMKK LKTNFALNLQ KIGCTNTTQD IDSINDDLFH
960 970 980 990 1000
WIGISIDIKT LNIIQNINIK KEGILCTLNV NMQTNESILW LKKKLKSFLM
1010 1020 1030 1040 1050
NNISFYFKST INTKQFANIT LSKLYIAAAE KYVACCQEFK RFHENTSLGG
1060 1070 1080 1090 1100
QNIDIKIIHI IYVVIRSFFK YLVCNVKSPV FERDDYQQFF IYSLKFFITR
1110 1120 1130
FKQQKNEFAG VYKILKAKEK KLEVAKIEFQ IQ
Length:1,132
Mass (Da):134,125
Last modified:November 1, 1998 - v1
Checksum:i81E145F5F24392DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060230 Genomic DNA. Translation: AAC39163.1.
PIRiT31107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060230 Genomic DNA. Translation: AAC39163.1.
PIRiT31107.

3D structure databases

ProteinModelPortaliO76332.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO76332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000477. RT_dom.
IPR021891. Telomerase_RBD.
IPR003545. Telomerase_RT.
[Graphical view]
PANTHERiPTHR12066:SF0. PTHR12066:SF0. 1 hit.
PfamiPF12009. Telomerase_RBD. 1 hit.
[Graphical view]
PRINTSiPR01365. TELOMERASERT.
SMARTiSM00975. Telomerase_RBD. 1 hit.
[Graphical view]
PROSITEiPS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTERT_OXYTR
AccessioniPrimary (citable) accession number: O76332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.