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Protein
Submitted name:

Pteridine reductase

Gene

PTR1

Organism
Trypanosoma brucei brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateCombined sources1
Active sitei161Proton donor/acceptorCombined sources1
Active sitei174Proton donor/acceptorCombined sources1
Binding sitei174NADPCombined sources1
Binding sitei178NADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 15NADPCombined sources2
Nucleotide bindingi35 – 37NADPCombined sources3
Nucleotide bindingi62 – 64NADPCombined sources3
Nucleotide bindingi93 – 95NADPCombined sources3
Nucleotide bindingi204 – 208NADPCombined sources5

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • pteridine reductase activity Source: CACAO

Keywordsi

LigandNADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

SABIO-RKiO76290.

Names & Taxonomyi

Protein namesi
Submitted name:
Pteridine reductaseImported
Gene namesi
Name:PTR1Imported
OrganismiTrypanosoma brucei bruceiImported
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7VX-ray2.20A/B/C/D1-268[»]
2VZ0X-ray1.90A/B/C/D1-268[»]
2WD7X-ray1.90A/B/C/D1-268[»]
2WD8X-ray2.10A/B/C/D1-268[»]
2X9GX-ray1.10A/B/C/D1-268[»]
2X9NX-ray1.15A/B/C/D1-268[»]
2X9VX-ray1.30A/B/C/D1-268[»]
2YHUX-ray2.01A/B/C/D1-268[»]
3BMCX-ray2.60A/B/C/D1-268[»]
3BMNX-ray1.98A/B/C/D1-268[»]
3BMOX-ray1.60A/B/C/D1-268[»]
3BMQX-ray1.70A/B/C/D1-268[»]
3GN1X-ray2.00A/B/C/D1-268[»]
3GN2X-ray1.60A/B/C/D1-268[»]
3MCVX-ray1.70A/B/C/D1-268[»]
4CL8X-ray2.20A/B/C/D1-268[»]
4CLDX-ray1.77A/B/C/D1-268[»]
4CLEX-ray1.80A/B/C/D1-268[»]
4CLHX-ray1.85A/B/C/D1-268[»]
4CLOX-ray1.88A/B/C/D1-268[»]
4CLRX-ray1.75A/B/C/D1-268[»]
4CLXX-ray1.85A/B/C/D1-268[»]
4CM1X-ray1.90A/B/C/D1-268[»]
4CM3X-ray1.95A/B/C/D1-268[»]
4CM4X-ray1.81A/B/C/D1-268[»]
4CM5X-ray1.99A/B/C/D1-268[»]
4CM6X-ray1.70A/B/C/D1-268[»]
4CM7X-ray1.90A/B/C/D1-268[»]
4CM8X-ray1.90A/B/C/D1-268[»]
4CM9X-ray1.90A/B/C/D1-268[»]
4CMAX-ray1.85A/B/C/D1-268[»]
4CMBX-ray1.96A/B/C/D1-268[»]
4CMCX-ray1.85A/B/C/D1-268[»]
4CMEX-ray1.85A/B/C/D1-268[»]
4CMGX-ray2.00A/B/C/D1-268[»]
4CMIX-ray1.90A/B/C/D1-268[»]
4CMJX-ray2.20A/B/C/D1-268[»]
4CMKX-ray2.00A/B/C/D1-268[»]
4WCDX-ray1.68A/B/C/D1-268[»]
4WCFX-ray1.93A/B/C/D1-268[»]
5IZCX-ray1.92A/B/C/D1-268[»]
5JCJX-ray1.76A/B/C/D1-268[»]
5JCXX-ray1.43A/B/C/D1-268[»]
5JDCX-ray1.78A/B/C/D1-268[»]
5JDIX-ray1.38A/B/C/D1-268[»]
5K6AX-ray1.70A/B/C/D1-268[»]
ProteinModelPortaliO76290.
SMRiO76290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76290.

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR014058. Pteridine_reductase.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02685. pter_reduc_Leis. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

O76290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAAVVTG AAKRIGRAIA VKLHQTGYRV VIHYHNSAEA AVSLADELNK
60 70 80 90 100
ERSNTAVVCQ ADLTNSNVLP ASCEEIINSC FRAFGRCDVL VNNASAFYPT
110 120 130 140 150
PLVQGDHEDN SNGKTVETQV AELIGTNAIA PFLLTMSFAQ RQKGTNPNCT
160 170 180 190 200
SSNLSIVNLC DAMVDQPCMA FSLYNMGKHA LVGLTQSAAL ELAPYGIRVN
210 220 230 240 250
GVAPGVSLLP VAMGEEEKDK WRRKVPLGRR EASAEQIADA VIFLVSGSAQ
260
YITGSIIKVD GGLSLVHA
Length:268
Mass (Da):28,470
Last modified:November 1, 1998 - v1
Checksum:i346C8257BDC9DD3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049903 mRNA. Translation: AAC23562.1.

Similar proteinsi

Entry informationi

Entry nameiO76290_TRYBB
AccessioniPrimary (citable) accession number: O76290
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources