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Protein
Submitted name:

Pteridine reductase

Gene

PTR1

Organism
Trypanosoma brucei brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateCombined sources1
Active sitei161Proton donor/acceptorCombined sources1
Active sitei174Proton donor/acceptorCombined sources1
Binding sitei174NADPCombined sources1
Binding sitei178NADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 15NADPCombined sources2
Nucleotide bindingi35 – 37NADPCombined sources3
Nucleotide bindingi62 – 64NADPCombined sources3
Nucleotide bindingi93 – 95NADPCombined sources3
Nucleotide bindingi204 – 208NADPCombined sources5

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • pteridine reductase activity Source: CACAO
Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Pteridine reductaseImported
Gene namesi
Name:PTR1Imported
OrganismiTrypanosoma brucei bruceiImported
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7VX-ray2.20A/B/C/D1-268[»]
2VZ0X-ray1.90A/B/C/D1-268[»]
2WD7X-ray1.90A/B/C/D1-268[»]
2WD8X-ray2.10A/B/C/D1-268[»]
2X9GX-ray1.10A/B/C/D1-268[»]
2X9NX-ray1.15A/B/C/D1-268[»]
2X9VX-ray1.30A/B/C/D1-268[»]
2YHUX-ray2.01A/B/C/D1-268[»]
3BMCX-ray2.60A/B/C/D1-268[»]
3BMNX-ray1.98A/B/C/D1-268[»]
3BMOX-ray1.60A/B/C/D1-268[»]
3BMQX-ray1.70A/B/C/D1-268[»]
3GN1X-ray2.00A/B/C/D1-268[»]
3GN2X-ray1.60A/B/C/D1-268[»]
3MCVX-ray1.70A/B/C/D1-268[»]
4CL8X-ray2.20A/B/C/D1-268[»]
4CLDX-ray1.77A/B/C/D1-268[»]
4CLEX-ray1.80A/B/C/D1-268[»]
4CLHX-ray1.85A/B/C/D1-268[»]
4CLOX-ray1.88A/B/C/D1-268[»]
4CLRX-ray1.75A/B/C/D1-268[»]
4CLXX-ray1.85A/B/C/D1-268[»]
4CM1X-ray1.90A/B/C/D1-268[»]
4CM3X-ray1.95A/B/C/D1-268[»]
4CM4X-ray1.81A/B/C/D1-268[»]
4CM5X-ray1.99A/B/C/D1-268[»]
4CM6X-ray1.70A/B/C/D1-268[»]
4CM7X-ray1.90A/B/C/D1-268[»]
4CM8X-ray1.90A/B/C/D1-268[»]
4CM9X-ray1.90A/B/C/D1-268[»]
4CMAX-ray1.85A/B/C/D1-268[»]
4CMBX-ray1.96A/B/C/D1-268[»]
4CMCX-ray1.85A/B/C/D1-268[»]
4CMEX-ray1.85A/B/C/D1-268[»]
4CMGX-ray2.00A/B/C/D1-268[»]
4CMIX-ray1.90A/B/C/D1-268[»]
4CMJX-ray2.20A/B/C/D1-268[»]
4CMKX-ray2.00A/B/C/D1-268[»]
4WCDX-ray1.68A/B/C/D1-268[»]
4WCFX-ray1.93A/B/C/D1-268[»]
5JCJX-ray1.76A/B/C/D1-268[»]
5JCXX-ray1.43A/B/C/D1-268[»]
5JDCX-ray1.78A/B/C/D1-268[»]
5JDIX-ray1.38A/B/C/D1-268[»]
ProteinModelPortaliO76290.
SMRiO76290.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76290.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR014058. Pteridine_reductase.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02685. pter_reduc_Leis. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAAVVTG AAKRIGRAIA VKLHQTGYRV VIHYHNSAEA AVSLADELNK
60 70 80 90 100
ERSNTAVVCQ ADLTNSNVLP ASCEEIINSC FRAFGRCDVL VNNASAFYPT
110 120 130 140 150
PLVQGDHEDN SNGKTVETQV AELIGTNAIA PFLLTMSFAQ RQKGTNPNCT
160 170 180 190 200
SSNLSIVNLC DAMVDQPCMA FSLYNMGKHA LVGLTQSAAL ELAPYGIRVN
210 220 230 240 250
GVAPGVSLLP VAMGEEEKDK WRRKVPLGRR EASAEQIADA VIFLVSGSAQ
260
YITGSIIKVD GGLSLVHA
Length:268
Mass (Da):28,470
Last modified:November 1, 1998 - v1
Checksum:i346C8257BDC9DD3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049903 mRNA. Translation: AAC23562.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049903 mRNA. Translation: AAC23562.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7VX-ray2.20A/B/C/D1-268[»]
2VZ0X-ray1.90A/B/C/D1-268[»]
2WD7X-ray1.90A/B/C/D1-268[»]
2WD8X-ray2.10A/B/C/D1-268[»]
2X9GX-ray1.10A/B/C/D1-268[»]
2X9NX-ray1.15A/B/C/D1-268[»]
2X9VX-ray1.30A/B/C/D1-268[»]
2YHUX-ray2.01A/B/C/D1-268[»]
3BMCX-ray2.60A/B/C/D1-268[»]
3BMNX-ray1.98A/B/C/D1-268[»]
3BMOX-ray1.60A/B/C/D1-268[»]
3BMQX-ray1.70A/B/C/D1-268[»]
3GN1X-ray2.00A/B/C/D1-268[»]
3GN2X-ray1.60A/B/C/D1-268[»]
3MCVX-ray1.70A/B/C/D1-268[»]
4CL8X-ray2.20A/B/C/D1-268[»]
4CLDX-ray1.77A/B/C/D1-268[»]
4CLEX-ray1.80A/B/C/D1-268[»]
4CLHX-ray1.85A/B/C/D1-268[»]
4CLOX-ray1.88A/B/C/D1-268[»]
4CLRX-ray1.75A/B/C/D1-268[»]
4CLXX-ray1.85A/B/C/D1-268[»]
4CM1X-ray1.90A/B/C/D1-268[»]
4CM3X-ray1.95A/B/C/D1-268[»]
4CM4X-ray1.81A/B/C/D1-268[»]
4CM5X-ray1.99A/B/C/D1-268[»]
4CM6X-ray1.70A/B/C/D1-268[»]
4CM7X-ray1.90A/B/C/D1-268[»]
4CM8X-ray1.90A/B/C/D1-268[»]
4CM9X-ray1.90A/B/C/D1-268[»]
4CMAX-ray1.85A/B/C/D1-268[»]
4CMBX-ray1.96A/B/C/D1-268[»]
4CMCX-ray1.85A/B/C/D1-268[»]
4CMEX-ray1.85A/B/C/D1-268[»]
4CMGX-ray2.00A/B/C/D1-268[»]
4CMIX-ray1.90A/B/C/D1-268[»]
4CMJX-ray2.20A/B/C/D1-268[»]
4CMKX-ray2.00A/B/C/D1-268[»]
4WCDX-ray1.68A/B/C/D1-268[»]
4WCFX-ray1.93A/B/C/D1-268[»]
5JCJX-ray1.76A/B/C/D1-268[»]
5JCXX-ray1.43A/B/C/D1-268[»]
5JDCX-ray1.78A/B/C/D1-268[»]
5JDIX-ray1.38A/B/C/D1-268[»]
ProteinModelPortaliO76290.
SMRiO76290.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO76290.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR014058. Pteridine_reductase.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02685. pter_reduc_Leis. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO76290_TRYBB
AccessioniPrimary (citable) accession number: O76290
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.