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Protein

Polar tube protein 1

Gene

PTP1

Organism
Encephalitozoon hellem (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name:
Major PTP
PTP Eh55
Gene namesi
Name:PTP1
Synonyms:PTP55
OrganismiEncephalitozoon hellem (Microsporidian parasite)
Taxonomic identifieri27973 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000002218223 – 453Polar tube protein 1Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Found in spores. Expression is high during polar tube formation.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati214 – 2331Add BLAST20
Repeati234 – 2532Add BLAST20
Repeati254 – 2733Add BLAST20
Repeati274 – 2934Add BLAST20
Repeati294 – 3135Add BLAST20
Repeati314 – 3336Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 3336 X 20 AA approximate tandem repeatsAdd BLAST120

Keywords - Domaini

Repeat, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI
60 70 80 90 100
TNCAYSPKNA YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD
110 120 130 140 150
TPGASSTPCE PEQTIPAQPV TMATVTPAII ASVQTPSVVS VIPVTQKVIQ
160 170 180 190 200
PATMIVPPSS IIPGYYPNGT PAAPGQQGQI LSGSVLAPGA SSCQLVPGNT
210 220 230 240 250
PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG GSGSNQTIPG
260 270 280 290 300
VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG
310 320 330 340 350
GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP
360 370 380 390 400
GQCVSVPQTP NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS
410 420 430 440 450
SCESQTNEKS TMQYAMEACA APTPTVVIGN SEYLVGPGMY SSLTSPCNSC

CQC
Length:453
Mass (Da):45,461
Last modified:November 1, 1998 - v1
Checksum:iDE519DFC6FF7F963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPTP1_ENCHE
AccessioniPrimary (citable) accession number: O76273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.