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O76273 (PTP1_ENCHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name=Major PTP
PTP Eh55
Gene names
Name:PTP1
Synonyms:PTP55
OrganismEncephalitozoon hellem (Microsporidian parasite)
Taxonomic identifier27973 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

Subcellular location

Spore polar tube Ref.1.

Developmental stage

Found in spores. Expression is high during polar tube formation. Ref.1

Post-translational modification

O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

Ontologies

Keywords
   Biological processSporulation
   DomainRepeat
Signal
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processsporulation resulting in formation of a cellular spore

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentpolar tube

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 453431Polar tube protein 1
PRO_0000022182

Regions

Repeat214 – 233201
Repeat234 – 253202
Repeat254 – 273203
Repeat274 – 293204
Repeat294 – 313205
Repeat314 – 333206
Region214 – 3331206 X 20 AA approximate tandem repeats

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation2851N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O76273 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: DE519DFC6FF7F963

FASTA45345,461
        10         20         30         40         50         60 
MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI TNCAYSPKNA 

        70         80         90        100        110        120 
YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD TPGASSTPCE PEQTIPAQPV 

       130        140        150        160        170        180 
TMATVTPAII ASVQTPSVVS VIPVTQKVIQ PATMIVPPSS IIPGYYPNGT PAAPGQQGQI 

       190        200        210        220        230        240 
LSGSVLAPGA SSCQLVPGNT PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG 

       250        260        270        280        290        300 
GSGSNQTIPG VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG 

       310        320        330        340        350        360 
GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP GQCVSVPQTP 

       370        380        390        400        410        420 
NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS SCESQTNEKS TMQYAMEACA 

       430        440        450 
APTPTVVIGN SEYLVGPGMY SSLTSPCNSC CQC 

« Hide

References

[1]"The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans."
Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., Weiss L.M.
Mol. Biochem. Parasitol. 94:227-236(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[2]"Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans."
Xu Y., Takvorian P.M., Cali A., Orr G.A., Weiss L.M.
Infect. Immun. 72:6341-6350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: O-MANNOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044915 Genomic DNA. Translation: AAC32812.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePTP1_ENCHE
AccessionPrimary (citable) accession number: O76273
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program