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O76273

- PTP1_ENCHE

UniProt

O76273 - PTP1_ENCHE

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Protein

Polar tube protein 1

Gene

PTP1

Organism
Encephalitozoon hellem (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

GO - Biological processi

  1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name:
Major PTP
PTP Eh55
Gene namesi
Name:PTP1
Synonyms:PTP55
OrganismiEncephalitozoon hellem (Microsporidian parasite)
Taxonomic identifieri27973 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Subcellular locationi

Spore polar tube 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 453431Polar tube protein 1PRO_0000022182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Found in spores. Expression is high during polar tube formation.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati214 – 233201Add
BLAST
Repeati234 – 253202Add
BLAST
Repeati254 – 273203Add
BLAST
Repeati274 – 293204Add
BLAST
Repeati294 – 313205Add
BLAST
Repeati314 – 333206Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 3331206 X 20 AA approximate tandem repeatsAdd
BLAST

Keywords - Domaini

Repeat, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76273-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI
60 70 80 90 100
TNCAYSPKNA YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD
110 120 130 140 150
TPGASSTPCE PEQTIPAQPV TMATVTPAII ASVQTPSVVS VIPVTQKVIQ
160 170 180 190 200
PATMIVPPSS IIPGYYPNGT PAAPGQQGQI LSGSVLAPGA SSCQLVPGNT
210 220 230 240 250
PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG GSGSNQTIPG
260 270 280 290 300
VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG
310 320 330 340 350
GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP
360 370 380 390 400
GQCVSVPQTP NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS
410 420 430 440 450
SCESQTNEKS TMQYAMEACA APTPTVVIGN SEYLVGPGMY SSLTSPCNSC

CQC
Length:453
Mass (Da):45,461
Last modified:November 1, 1998 - v1
Checksum:iDE519DFC6FF7F963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans."
    Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., Weiss L.M.
    Mol. Biochem. Parasitol. 94:227-236(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  2. "Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans."
    Xu Y., Takvorian P.M., Cali A., Orr G.A., Weiss L.M.
    Infect. Immun. 72:6341-6350(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: O-MANNOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPTP1_ENCHE
AccessioniPrimary (citable) accession number: O76273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program