SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O76273

- PTP1_ENCHE

UniProt

O76273 - PTP1_ENCHE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polar tube protein 1

Gene
PTP1, PTP55
Organism
Encephalitozoon hellem (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

GO - Biological processi

  1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polar tube protein 1
Alternative name(s):
Major polar tube protein
Short name:
Major PTP
PTP Eh55
Gene namesi
Name:PTP1
Synonyms:PTP55
OrganismiEncephalitozoon hellem (Microsporidian parasite)
Taxonomic identifieri27973 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Subcellular locationi

Spore polar tube 1 Publication

GO - Cellular componenti

  1. polar tube Source: UniProtKB-SubCell
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityAdd
BLAST
Chaini23 – 453431Polar tube protein 1PRO_0000022182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi245 – 2451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Found in spores. Expression is high during polar tube formation.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati214 – 233201Add
BLAST
Repeati234 – 253202Add
BLAST
Repeati254 – 273203Add
BLAST
Repeati274 – 293204Add
BLAST
Repeati294 – 313205Add
BLAST
Repeati314 – 333206Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni214 – 3331206 X 20 AA approximate tandem repeatsAdd
BLAST

Keywords - Domaini

Repeat, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76273-1 [UniParc]FASTAAdd to Basket

« Hide

MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI    50
TNCAYSPKNA YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD 100
TPGASSTPCE PEQTIPAQPV TMATVTPAII ASVQTPSVVS VIPVTQKVIQ 150
PATMIVPPSS IIPGYYPNGT PAAPGQQGQI LSGSVLAPGA SSCQLVPGNT 200
PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG GSGSNQTIPG 250
VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG 300
GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP 350
GQCVSVPQTP NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS 400
SCESQTNEKS TMQYAMEACA APTPTVVIGN SEYLVGPGMY SSLTSPCNSC 450
CQC 453
Length:453
Mass (Da):45,461
Last modified:November 1, 1998 - v1
Checksum:iDE519DFC6FF7F963
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044915 Genomic DNA. Translation: AAC32812.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans."
    Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., Weiss L.M.
    Mol. Biochem. Parasitol. 94:227-236(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  2. "Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans."
    Xu Y., Takvorian P.M., Cali A., Orr G.A., Weiss L.M.
    Infect. Immun. 72:6341-6350(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: O-MANNOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPTP1_ENCHE
AccessioniPrimary (citable) accession number: O76273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Similar proteinsi