Polar tube protein 1 precursor - Encephalitozoon hellem (Microsporidian parasite)

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O76273 (PTP1_ENCHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 29. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Polar tube protein 1

Alternative name(s):
Major polar tube protein
Short name=Major PTP
PTP Eh55

Gene names

Name:	PTP1
Synonyms:	PTP55

Organism

Encephalitozoon hellem (Microsporidian parasite)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.
Subcellular location	Spore polar tube Ref.1.
Developmental stage	Found in spores. Expression is high during polar tube formation. Ref.1
Post-translational modification	O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

Ontologies

Keywords
Biological process	Sporulation
Domain	Repeat Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	polar tube Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

22

By similarity

Chain

431

Polar tube protein 1

PRO_0000022182

Regions

Repeat

20

1

Repeat

20

2

Repeat

20

3

Repeat

20

4

Repeat

20

5

Repeat

20

6

Region

120

6 X 20 AA approximate tandem repeats

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O76273 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: DE519DFC6FF7F963
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453

45,461

        10         20         30         40         50         60 
MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI TNCAYSPKNA 

        70         80         90        100        110        120 
YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD TPGASSTPCE PEQTIPAQPV 

       130        140        150        160        170        180 
TMATVTPAII ASVQTPSVVS VIPVTQKVIQ PATMIVPPSS IIPGYYPNGT PAAPGQQGQI 

       190        200        210        220        230        240 
LSGSVLAPGA SSCQLVPGNT PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG 

       250        260        270        280        290        300 
GSGSNQTIPG VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG 

       310        320        330        340        350        360 
GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP GQCVSVPQTP 

       370        380        390        400        410        420 
NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS SCESQTNEKS TMQYAMEACA 

       430        440        450 
APTPTVVIGN SEYLVGPGMY SSLTSPCNSC CQC

References

[1]

"The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans."
Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., Weiss L.M.
Mol. Biochem. Parasitol. 94:227-236(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

[2]

"Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans."
Xu Y., Takvorian P.M., Cali A., Orr G.A., Weiss L.M.
Infect. Immun. 72:6341-6350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY, O-MANNOSYLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044915 Genomic DNA. Translation: AAC32812.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PTP1_ENCHE

Accession

Primary (citable) accession number: O76273

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info