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O76273

- PTP1_ENCHE

UniProt

O76273 - PTP1_ENCHE

Protein

Polar tube protein 1

Gene

PTP1

Organism
Encephalitozoon hellem (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

    GO - Biological processi

    1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Sporulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polar tube protein 1
    Alternative name(s):
    Major polar tube protein
    Short name:
    Major PTP
    PTP Eh55
    Gene namesi
    Name:PTP1
    Synonyms:PTP55
    OrganismiEncephalitozoon hellem (Microsporidian parasite)
    Taxonomic identifieri27973 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

    Subcellular locationi

    Spore polar tube 1 Publication

    GO - Cellular componenti

    1. polar tube Source: UniProtKB-SubCell

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 453431Polar tube protein 1PRO_0000022182Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O-mannosylated. O-mannosylation has functional significance for the ability of microsporidia to invade their host cells.

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Developmental stagei

    Found in spores. Expression is high during polar tube formation.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati214 – 233201Add
    BLAST
    Repeati234 – 253202Add
    BLAST
    Repeati254 – 273203Add
    BLAST
    Repeati274 – 293204Add
    BLAST
    Repeati294 – 313205Add
    BLAST
    Repeati314 – 333206Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 3331206 X 20 AA approximate tandem repeatsAdd
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O76273-1 [UniParc]FASTAAdd to Basket

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    MKGISKILSA SIMVMKLGNV YSAVPLCSNT YDPSQQQPSY VLIPSTPEAI    50
    TNCAYSPKNA YVPSSPTTSS STPGTNNDNE TSPTTEDVGT CKISVVKHCD 100
    TPGASSTPCE PEQTIPAQPV TMATVTPAII ASVQTPSVVS VIPVTQKVIQ 150
    PATMIVPPSS IIPGYYPNGT PAAPGQQGQI LSGSVLAPGA SSCQLVPGNT 200
    PGQMLPGMTP GVSPCLPTQG GDGSNQTIPG IVYPCQPGQG GSGSNQTIPG 250
    VISPCQPGQG GSGSNQTIPG IVYPCQPGQG GSGSNQTIPG VISPCQPGQG 300
    GSGSNQTIPG IVYPCQPGQN GDGSNQTIPG VISPCQPGQG GNGNGTTGQP 350
    GQCVSVPQTP NPIAMPPISG ISGNGYPTST TYTQSLGQLG PCIDVQKPTS 400
    SCESQTNEKS TMQYAMEACA APTPTVVIGN SEYLVGPGMY SSLTSPCNSC 450
    CQC 453
    Length:453
    Mass (Da):45,461
    Last modified:November 1, 1998 - v1
    Checksum:iDE519DFC6FF7F963
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044915 Genomic DNA. Translation: AAC32812.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044915 Genomic DNA. Translation: AAC32812.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The molecular characterization of the major polar tube protein gene from Encephalitozoon hellem, a microsporidian parasite of humans."
      Keohane E.M., Orr G.A., Zhang H.S., Takvorian P.M., Cali A., Tanowitz H.B., Wittner M., Weiss L.M.
      Mol. Biochem. Parasitol. 94:227-236(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    2. "Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans."
      Xu Y., Takvorian P.M., Cali A., Orr G.A., Weiss L.M.
      Infect. Immun. 72:6341-6350(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: O-MANNOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPTP1_ENCHE
    AccessioniPrimary (citable) accession number: O76273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program