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Protein
Submitted name:

G-protein-coupled 5-hydroxytryptamine receptor

Gene

5-HTap1

Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
G-protein-coupled 5-hydroxytryptamine receptorImported
Gene namesi
Name:5-HTap1Imported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 10328HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13723HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17322HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21523HelicalSequence analysisAdd
BLAST
Transmembranei235 – 26026HelicalSequence analysisAdd
BLAST
Transmembranei408 – 43326HelicalSequence analysisAdd
BLAST
Transmembranei445 – 46925HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO76267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 466373G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWHNISVQR MGRNASLLEA NMYAMFPGYN ITTGWPPRDN NSNNSGYFDQ
60 70 80 90 100
VTVNGSDRPE LLRQYNYHEP KYEEPVMIVI CIFLGCMILA IILGNIFVIT
110 120 130 140 150
AILVEKSLQG VSNYLILSLA VTDLLVAVLV MPLSLIYEIS IHWFLGNAVC
160 170 180 190 200
DMWVSMDVLC CTASILHLVA IAFDRYWAVS NIDYVRSRNA RQILLMVAIV
210 220 230 240 250
WTVSVFISIS PLFGWRHDSD DPELTGQCLI SQDHGYTVFS TVGRFYCPLL
260 270 280 290 300
LMLVINFKIY RAARYRIRKK RFGGRGGKHQ ALHVPLPAVT VDTSHRQILA
310 320 330 340 350
TLEGDVSQDG ISMYMPSCTN AMTSTRVEHG ETARCPGEWS TRRPAGSKPD
360 370 380 390 400
SHVVQHTDRP SMHLLASPYP VQEPRSRFQQ QRHQKTETHR QRVVFRREKM
410 420 430 440 450
EMARERKVWL RVLGIITGAF VVCWLPFFVV AVVKPMCGTP CDMPSYVYSL
460 470 480 490
FLWLGYVNSL INPIIYTIFN PSFRCAFNKI FLRRIKSVNR IT
Length:492
Mass (Da):56,262
Last modified:November 1, 1998 - v1
Checksum:i24F0044CA94901B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041039 mRNA. Translation: AAC28786.1.
RefSeqiNP_001191550.1. NM_001204621.1.
UniGeneiAcl.14763.

Genome annotation databases

GeneIDi100533324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041039 mRNA. Translation: AAC28786.1.
RefSeqiNP_001191550.1. NM_001204621.1.
UniGeneiAcl.14763.

3D structure databases

ProteinModelPortaliO76267.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533324.

Organism-specific databases

CTDi100533324.

Family and domain databases

InterProiIPR000610. 5HT1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional expression of an Aplysia 5-HT receptor negatively coupled to adenylate cyclase."
    Angers A., Storozhuk M.V., Duchaine T., Castellucci V.F., DesGroseillers L.
    J. Neurosci. 18:5586-5593(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76267_APLCA
AccessioniPrimary (citable) accession number: O76267
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.