Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neural hemoglobin

Gene
N/A
Organism
Cerebratulus lacteus (Milky ribbon worm) (Micrura lactea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an oxygen store capable of sustaining neuronal activity in an anoxic environment for 5 to 30 min.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural hemoglobin
Short name:
NrHb
OrganismiCerebratulus lacteus (Milky ribbon worm) (Micrura lactea)
Taxonomic identifieri6221 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaNemerteaAnoplaHeteronemerteaCerebratulidaeCerebratulus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 110109Neural hemoglobinPRO_0000052499Add
BLAST

Interactioni

Subunit structurei

Homotetramer. Self-associates in the deoxy state. Seems to dissociate upon oxygenation.1 Publication

Structurei

Secondary structure

1
110
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1815Combined sources
Helixi20 – 256Combined sources
Turni27 – 304Combined sources
Helixi33 – 386Combined sources
Helixi40 – 5819Combined sources
Helixi63 – 719Combined sources
Turni72 – 743Combined sources
Helixi77 – 9317Combined sources
Helixi100 – 1078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KR7X-ray1.50A1-110[»]
1V07X-ray1.70A2-110[»]
2VYYX-ray1.60A1-110[»]
2VYZX-ray1.80A1-110[»]
2XKGX-ray1.60A1-110[»]
2XKHX-ray2.31A1-110[»]
2XKIX-ray1.30A1-110[»]
4AVDX-ray1.50A1-110[»]
4AVEX-ray1.90A1-110[»]
4F68X-ray1.80A1-110[»]
4F69X-ray1.60A1-110[»]
4F6BX-ray1.64A1-110[»]
4F6DX-ray1.80A1-110[»]
4F6FX-ray1.56A1-110[»]
4F6GX-ray1.64A1-110[»]
4F6IX-ray1.56A1-110[»]
4F6JX-ray1.45A1-110[»]
ProteinModelPortaliO76242.
SMRiO76242. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76242.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.Curated

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNWAAVVDD FYQELFKAHP EYQNKFGFKG VALGSLKGNA AYKTQAGKTV
60 70 80 90 100
DYINAAIGGS ADAAGLASRH KGRNVGSAEF HNAKACLAKA CSAHGAPDLG
110
HAIDDILSHL
Length:110
Mass (Da):11,530
Last modified:January 23, 2007 - v3
Checksum:i0F30C4420773F244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033001 Genomic DNA. Translation: AAC39125.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033001 Genomic DNA. Translation: AAC39125.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KR7X-ray1.50A1-110[»]
1V07X-ray1.70A2-110[»]
2VYYX-ray1.60A1-110[»]
2VYZX-ray1.80A1-110[»]
2XKGX-ray1.60A1-110[»]
2XKHX-ray2.31A1-110[»]
2XKIX-ray1.30A1-110[»]
4AVDX-ray1.50A1-110[»]
4AVEX-ray1.90A1-110[»]
4F68X-ray1.80A1-110[»]
4F69X-ray1.60A1-110[»]
4F6BX-ray1.64A1-110[»]
4F6DX-ray1.80A1-110[»]
4F6FX-ray1.56A1-110[»]
4F6GX-ray1.64A1-110[»]
4F6IX-ray1.56A1-110[»]
4F6JX-ray1.45A1-110[»]
ProteinModelPortaliO76242.
SMRiO76242. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO76242.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The mini-hemoglobins in neural and body wall tissue of the nemertean worm, Cerebratulus lacteus."
    Vandergon T.L., Riggs C.K., Gorr T.A., Colacino J.M., Riggs A.F.
    J. Biol. Chem. 273:16998-17011(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-44, CHARACTERIZATION.
    Tissue: Brain.
  2. "Crystallization and preliminary X-ray analysis of neural haemoglobin from the nemertean worm Cerebratulus lacteus."
    Pesce A., Nardini M., Dewilde S., Ascenzi P., Riggs A.F., Yamauchi K., Geuens E., Moens L., Bolognesi M.
    Acta Crystallogr. D 57:1897-1899(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.
  3. "The 109 residue nerve tissue minihemoglobin from Cerebratulus lacteus highlights striking structural plasticity of the alpha-helical globin fold."
    Pesce A., Nardini M., Dewilde S., Geuens E., Yamauchi K., Ascenzi P., Riggs A.F., Moens L., Bolognesi M.
    Structure 10:725-735(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH HEME.

Entry informationi

Entry nameiGLBN_CERLA
AccessioniPrimary (citable) accession number: O76242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.