Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peritrophin-1

Gene

Aper1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds chitin but not cellulose. May be involved in the spatial organization of PM.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Peritrophin-1
Alternative name(s):
AgAper-1
Peritrophic matrix protein 1
Peritrophin A
Gene namesi
Name:Aper1
ORF Names:AGAP006795
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Chromosome 2L

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 153136Peritrophin-1PRO_0000023612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi130 ↔ 143PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Adult peritrophic membrane.1 Publication

Developmental stagei

Expressed in adult but not larval guts, whole pupae or whole bodies minus gut.

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP006795-PA.

Structurei

3D structure databases

ProteinModelPortaliO76217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 7962Chitin-binding type-2 1PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 15362Chitin-binding type-2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG275071.
InParanoidiO76217.
OrthoDBiEOG73V6N7.

Family and domain databases

Gene3Di2.170.140.10. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 2 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 2 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 2 hits.
PROSITEiPS50940. CHIT_BIND_II. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSASLVLL LAAAVLADDR CPPQDDPEQP PVLLAHPTDC DKFLICNHGT
60 70 80 90 100
PVVSKCPPGL LWNDSQKQCD YPAQAQCAPG VTPNTEPAPK PSPNCPPEYD
110 120 130 140 150
PDHMVYIPHE TDCGKYYICD PYGVELEQTC PSGLHWNPVV NYCDFPELAQ

CEE
Length:153
Mass (Da):16,791
Last modified:July 5, 2005 - v2
Checksum:i2207D5130F487338
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71L → V in strain: 4aRR, PEST.
Natural varianti19 – 191D → V in strain: 4aRR, PEST.
Natural varianti28 – 281E → K in strain: L3-5.
Natural varianti37 – 371P → S in strain: L3-5.
Natural varianti55 – 551K → Q in strain: Yaounde Yd41.
Natural varianti73 – 731A → S in strain: Yaounde Yd21, Yaounde Yd35, Yaounde Yd41.
Natural varianti88 – 881A → V in strain: G3.
Natural varianti89 – 891P → S in strain: 4aRR, PEST.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030431 mRNA. Translation: AAC39127.1.
AY750997 Genomic DNA. Translation: AAV31069.1.
AY344823 Genomic DNA. Translation: AAR02434.1.
AY344824 Genomic DNA. Translation: AAR02435.1.
AY344825 Genomic DNA. Translation: AAR02436.1.
AY344826 Genomic DNA. Translation: AAR02437.1.
AY344827 Genomic DNA. Translation: AAR02438.1.
AY344828 Genomic DNA. Translation: AAR02439.1.
AAAB01008807 Genomic DNA. Translation: EAA04177.3.
RefSeqiXP_308952.3. XM_308952.3.

Genome annotation databases

GeneIDi1270270.
KEGGiaga:AgaP_AGAP006795.
VectorBaseiAGAP006795. Anopheles gambiae.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030431 mRNA. Translation: AAC39127.1.
AY750997 Genomic DNA. Translation: AAV31069.1.
AY344823 Genomic DNA. Translation: AAR02434.1.
AY344824 Genomic DNA. Translation: AAR02435.1.
AY344825 Genomic DNA. Translation: AAR02436.1.
AY344826 Genomic DNA. Translation: AAR02437.1.
AY344827 Genomic DNA. Translation: AAR02438.1.
AY344828 Genomic DNA. Translation: AAR02439.1.
AAAB01008807 Genomic DNA. Translation: EAA04177.3.
RefSeqiXP_308952.3. XM_308952.3.

3D structure databases

ProteinModelPortaliO76217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP006795-PA.

Protein family/group databases

CAZyiCBM14. Carbohydrate-Binding Module Family 14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1270270.
KEGGiaga:AgaP_AGAP006795.
VectorBaseiAGAP006795. Anopheles gambiae.

Organism-specific databases

CTDi1270270.

Phylogenomic databases

eggNOGiNOG275071.
InParanoidiO76217.
OrthoDBiEOG73V6N7.

Family and domain databases

Gene3Di2.170.140.10. 2 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 2 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 2 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 2 hits.
PROSITEiPS50940. CHIT_BIND_II. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A type I peritrophic matrix protein from the malaria vector Anopheles gambiae binds to chitin. Cloning, expression, and characterization."
    Shen Z., Jacobs-Lorena M.
    J. Biol. Chem. 273:17665-17670(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: G3.
    Tissue: Midgut.
  2. "Anopheles peritrophic matrix protein-1 (AgAper-1) regulatory sequences mediate transgenic protein accumulation and secretion into the midgut lumen upon blood ingestion."
    Abraham E.G., Donnelly-Doman M., Fujioka H., Ghosh A., Moreira L., Jacobs-Lorena M.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors."
    Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.
    Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 4aRR, L3-5, L3-51, Yaounde Yd21, Yaounde Yd35 and Yaounde Yd41.
  4. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.

Entry informationi

Entry nameiPE1_ANOGA
AccessioniPrimary (citable) accession number: O76217
Secondary accession number(s): Q6VAW1
, Q6VAW2, Q6VAW4, Q6VAW5, Q6VAW6, Q7QID7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 5, 2005
Last modified: June 24, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.