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Protein
Submitted name:

GCN5

Gene

Gcn5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei546Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • H3 histone acetyltransferase activity Source: FlyBase
  • H4 histone acetyltransferase activity Source: FlyBase
  • histone acetyltransferase activity Source: FlyBase

GO - Biological processi

  • chromatin remodeling Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone H3 acetylation Source: FlyBase
  • histone H4 acetylation Source: FlyBase
  • regulation of transcription, DNA-templated Source: InterPro

Enzyme and pathway databases

ReactomeiR-DME-209394 Transcriptional activtion and repression of REL-68 target genes
R-DME-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Submitted name:
GCN5Imported
Gene namesi
Name:Gcn5Imported
Synonyms:PcafImported
ORF Names:CG4107Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020388 Gcn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiO76216
PRIDEiO76216

Expressioni

Gene expression databases

BgeeiFBgn0020388
ExpressionAtlasiO76216 baseline and differential

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO76216, 18 interactors
MINTiO76216

Structurei

3D structure databases

ProteinModelPortaliO76216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini481 – 627N-acetyltransferaseInterPro annotationAdd BLAST147
Domaini721 – 791BromoInterPro annotationAdd BLAST71

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1472 Eukaryota
COG5076 LUCA
OrthoDBiEOG091G03ZO

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR037800 GCN5
IPR016376 GCN5/PCAF
IPR000182 GNAT_dom
IPR009464 PCAF_N
PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF00439 Bromodomain, 1 hit
PF06466 PCAF_N, 1 hit
PIRSFiPIRSF003048 Histone_acetylase_PCAF, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

O76216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGPSITIK SQPIDGNNTG NAAAQQQQQA ANGAATAGAS GAAGSAQNPG
60 70 80 90 100
HGGAASGAGS VPAEGTRQNS LQRIQQRKQK VFNLPVPQKL AKLSMYSACQ
110 120 130 140 150
SEGCRCTGWK TPQENRHRDV ESSYCPEFNE ECRNTSCRHS LRSHIAHLDN
160 170 180 190 200
ISSSSMNELL GAIIDMENLF MSMQRVEDED TKKVYQYLFR LLRQCVLTRQ
210 220 230 240 250
QAVIRGPLGD PPFETPCITK AVLSLVFYKY NHLSTPELQT MTEVAKTFLN
260 270 280 290 300
FLNHYNFESP STRRGDLTHE DASNYKINYT RWLVFCHVPA FCNSLRQCET
310 320 330 340 350
SLVFGRTLLR TVFQCVSQQL KKKCISERDR FPEDKRSIIT LMPKFLETLR
360 370 380 390 400
AELLKDDSPI WDTSYRPSNS FVIQQRKRNQ EVASVPIGPS AASIGGNKRT
410 420 430 440 450
SVGEPLHKRI KKEPTDRPSS ENLDDLPADV VMRAMKSVSE SKTTNKAEIL
460 470 480 490 500
FPVNVSRDEN VKAEEQKRAI EFHVVGNSLT KPVDKQTVLW LLGLQLVFAY
510 520 530 540 550
QLPEMPREYI SQLVFDTKHK TLALIKENQP IGGICFRPFP SQGFTEIVFC
560 570 580 590 600
AVTMSEQVKG YGTHLMNHLK DYSIQRGIKH LLTFADCDAI GYFKKQGFSK
610 620 630 640 650
DVKLARPVYA GYIKEYDSAT LMHCELHPSI VNTQFIAVIR SQSEILKELI
660 670 680 690 700
AQRHNEVQKV RPGLTCFKEG LPVIPVESIP GLREIGWKPQ NRPARSSRPL
710 720 730 740 750
EESTDPEKLA TSFASVLQSV RQHTTAWPFL RPVTAAEVPD YYDHIKYPMD
760 770 780 790 800
LKTMGERLKK GYYQTRRLFM ADMARIFSNC RFYNSPDTEY YRCANSLERY
810
FQTKMRELGL WDK
Length:813
Mass (Da):92,096
Last modified:November 1, 1998 - v1
Checksum:i7983E218CBB98D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029776 mRNA Translation: AAC39102.1

Similar proteinsi

Entry informationi

Entry nameiO76216_DROME
AccessioniPrimary (citable) accession number: O76216
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health