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Protein
Submitted name:

GCN5

Gene

Gcn5

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei546 – 5461Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • H3 histone acetyltransferase activity Source: FlyBase
  • H4 histone acetyltransferase activity Source: FlyBase
  • histone acetyltransferase activity Source: FlyBase

GO - Biological processi

  • axon target recognition Source: FlyBase
  • chromatin remodeling Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • histone acetylation Source: FlyBase
  • histone H3 acetylation Source: FlyBase
  • histone H4 acetylation Source: FlyBase
  • muscle organ development Source: FlyBase
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
GCN5Imported
Gene namesi
Name:Gcn5Imported
Synonyms:PcafImported
ORF Names:CG4107Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020388. Gcn5.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: FlyBase
  • nucleus Source: FlyBase
  • polytene chromosome Source: FlyBase
  • polytene chromosome puff Source: FlyBase
  • SAGA complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO76216.
PRIDEiO76216.

Expressioni

Gene expression databases

BgeeiO76216.
ExpressionAtlasiO76216. differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ada2bQ8I8V07EBI-867710,EBI-109247
Rpb4Q7KSD8-45EBI-867710,EBI-1246969

Protein-protein interaction databases

IntActiO76216. 18 interactions.
MINTiMINT-6178880.
STRINGi7227.FBpp0075701.

Structurei

3D structure databases

ProteinModelPortaliO76216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini481 – 627147N-acetyltransferaseInterPro annotationAdd
BLAST
Domaini721 – 79171BromoInterPro annotationAdd
BLAST

Keywords - Domaini

BromodomainSAAS annotation

Phylogenomic databases

eggNOGiKOG1472. Eukaryota.
COG5076. LUCA.
OrthoDBiEOG7ZKS9B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGPSITIK SQPIDGNNTG NAAAQQQQQA ANGAATAGAS GAAGSAQNPG
60 70 80 90 100
HGGAASGAGS VPAEGTRQNS LQRIQQRKQK VFNLPVPQKL AKLSMYSACQ
110 120 130 140 150
SEGCRCTGWK TPQENRHRDV ESSYCPEFNE ECRNTSCRHS LRSHIAHLDN
160 170 180 190 200
ISSSSMNELL GAIIDMENLF MSMQRVEDED TKKVYQYLFR LLRQCVLTRQ
210 220 230 240 250
QAVIRGPLGD PPFETPCITK AVLSLVFYKY NHLSTPELQT MTEVAKTFLN
260 270 280 290 300
FLNHYNFESP STRRGDLTHE DASNYKINYT RWLVFCHVPA FCNSLRQCET
310 320 330 340 350
SLVFGRTLLR TVFQCVSQQL KKKCISERDR FPEDKRSIIT LMPKFLETLR
360 370 380 390 400
AELLKDDSPI WDTSYRPSNS FVIQQRKRNQ EVASVPIGPS AASIGGNKRT
410 420 430 440 450
SVGEPLHKRI KKEPTDRPSS ENLDDLPADV VMRAMKSVSE SKTTNKAEIL
460 470 480 490 500
FPVNVSRDEN VKAEEQKRAI EFHVVGNSLT KPVDKQTVLW LLGLQLVFAY
510 520 530 540 550
QLPEMPREYI SQLVFDTKHK TLALIKENQP IGGICFRPFP SQGFTEIVFC
560 570 580 590 600
AVTMSEQVKG YGTHLMNHLK DYSIQRGIKH LLTFADCDAI GYFKKQGFSK
610 620 630 640 650
DVKLARPVYA GYIKEYDSAT LMHCELHPSI VNTQFIAVIR SQSEILKELI
660 670 680 690 700
AQRHNEVQKV RPGLTCFKEG LPVIPVESIP GLREIGWKPQ NRPARSSRPL
710 720 730 740 750
EESTDPEKLA TSFASVLQSV RQHTTAWPFL RPVTAAEVPD YYDHIKYPMD
760 770 780 790 800
LKTMGERLKK GYYQTRRLFM ADMARIFSNC RFYNSPDTEY YRCANSLERY
810
FQTKMRELGL WDK
Length:813
Mass (Da):92,096
Last modified:November 1, 1998 - v1
Checksum:i7983E218CBB98D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029776 mRNA. Translation: AAC39102.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029776 mRNA. Translation: AAC39102.1.

3D structure databases

ProteinModelPortaliO76216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO76216. 18 interactions.
MINTiMINT-6178880.
STRINGi7227.FBpp0075701.

Proteomic databases

PaxDbiO76216.
PRIDEiO76216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0020388. Gcn5.

Phylogenomic databases

eggNOGiKOG1472. Eukaryota.
COG5076. LUCA.
OrthoDBiEOG7ZKS9B.

Gene expression databases

BgeeiO76216.
ExpressionAtlasiO76216. differential.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members."
    Smith E.R., Belote J.M., Schlitz R.L., Yang X.-J., Moore P.A., Berger S.L., Nakatani Y., Allis C.D.
    Nucleic Acids Res. 26:2948-2954(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76216_DROME
AccessioniPrimary (citable) accession number: O76216
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.