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O76206

- RIFK_DROME

UniProt

O76206 - RIFK_DROME

Protein

Putative riboflavin kinase

Gene

anon-84Ea

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).By similarity

    Catalytic activityi

    ATP + riboflavin = ADP + FMN.By similarity

    Cofactori

    Zinc or magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Magnesium or zincBy similarity
    Active sitei80 – 801NucleophileBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. riboflavin kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FMN biosynthetic process Source: UniProtKB-UniPathway
    2. riboflavin biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00276; UER00406.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative riboflavin kinase (EC:2.7.1.26)
    Alternative name(s):
    ATP:riboflavin 5'-phosphotransferase
    Flavokinase
    Gene namesi
    Name:anon-84Ea
    ORF Names:CG2846
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0014930. CG2846.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Putative riboflavin kinasePRO_0000194150Add
    BLAST

    Proteomic databases

    PaxDbiO76206.
    PRIDEiO76206.

    Expressioni

    Gene expression databases

    BgeeiO76206.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi7227.FBpp0081260.

    Structurei

    3D structure databases

    ProteinModelPortaliO76206.
    SMRiO76206. Positions 4-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0196.
    GeneTreeiENSGT00390000015537.
    InParanoidiO76206.
    KOiK00861.
    OMAiSLPYFCR.
    OrthoDBiEOG7K3TP0.
    PhylomeDBiO76206.

    Family and domain databases

    Gene3Di2.40.30.30. 1 hit.
    InterProiIPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view]
    PANTHERiPTHR22749. PTHR22749. 1 hit.
    PfamiPF01687. Flavokinase. 1 hit.
    [Graphical view]
    SMARTiSM00904. Flavokinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF82114. SSF82114. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O76206-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSQLPLFAG GEIVRGFGRG SKELGIPTAN FPLEVVKSLP ESLPTGAYYG    50
    WANVDNGPVH KMVLSIGWNP FYNNKEKSVE THMLHDFNCD LYGQTLKICI 100
    VGYLRPERSF DSLESLIAAI RGDIEQAKAF LDEADKAKLK EAPFFTEKLC 150
    SSK 153
    Length:153
    Mass (Da):16,986
    Last modified:November 1, 1998 - v1
    Checksum:i56FF3B5C043C0D22
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241L → M in AAL28446. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017096 Genomic DNA. Translation: AAC39087.1.
    AE014297 Genomic DNA. Translation: AAF54164.1.
    AY071393 mRNA. Translation: AAL49015.1.
    AY060898 mRNA. Translation: AAL28446.1.
    BT050515 mRNA. Translation: ACJ13222.1.
    RefSeqiNP_649749.2. NM_141492.2.
    UniGeneiDm.1095.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081763; FBpp0081260; FBgn0014930.
    GeneIDi40936.
    KEGGidme:Dmel_CG2846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017096 Genomic DNA. Translation: AAC39087.1 .
    AE014297 Genomic DNA. Translation: AAF54164.1 .
    AY071393 mRNA. Translation: AAL49015.1 .
    AY060898 mRNA. Translation: AAL28446.1 .
    BT050515 mRNA. Translation: ACJ13222.1 .
    RefSeqi NP_649749.2. NM_141492.2.
    UniGenei Dm.1095.

    3D structure databases

    ProteinModelPortali O76206.
    SMRi O76206. Positions 4-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0081260.

    Proteomic databases

    PaxDbi O76206.
    PRIDEi O76206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081763 ; FBpp0081260 ; FBgn0014930 .
    GeneIDi 40936.
    KEGGi dme:Dmel_CG2846.

    Organism-specific databases

    FlyBasei FBgn0014930. CG2846.

    Phylogenomic databases

    eggNOGi COG0196.
    GeneTreei ENSGT00390000015537.
    InParanoidi O76206.
    KOi K00861.
    OMAi SLPYFCR.
    OrthoDBi EOG7K3TP0.
    PhylomeDBi O76206.

    Enzyme and pathway databases

    UniPathwayi UPA00276 ; UER00406 .

    Miscellaneous databases

    GenomeRNAii 40936.
    NextBioi 821367.
    PROi O76206.

    Gene expression databases

    Bgeei O76206.

    Family and domain databases

    Gene3Di 2.40.30.30. 1 hit.
    InterProi IPR023468. Riboflavin_kinase.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    [Graphical view ]
    PANTHERi PTHR22749. PTHR22749. 1 hit.
    Pfami PF01687. Flavokinase. 1 hit.
    [Graphical view ]
    SMARTi SM00904. Flavokinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82114. SSF82114. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Repetitive arrays containing a housekeeping gene promoter have altered polytene chromosome morphology in Drosophila."
      Clark D.V., Sabl J.F., Henikoff S.
      Chromosoma 107:96-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Canton-S1 Publication.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley1 Publication.
      Tissue: Embryo1 Publication and Ovary1 Publication.
    5. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.

    Entry informationi

    Entry nameiRIFK_DROME
    AccessioniPrimary (citable) accession number: O76206
    Secondary accession number(s): B6IDS5, Q95S97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3