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Protein

Putative riboflavin kinase

Gene

anon-84Ea

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN).By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.By similarity

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative riboflavin kinase (anon-84Ea)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Magnesium or zincBy similarity
Active sitei80 – 801NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-196843. Vitamin B2 (riboflavin) metabolism.
UniPathwayiUPA00276; UER00406.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
ATP:riboflavin 5'-phosphotransferase
Flavokinase
Gene namesi
Name:anon-84Ea
ORF Names:CG2846
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0014930. CG2846.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Putative riboflavin kinasePRO_0000194150Add
BLAST

Proteomic databases

PaxDbiO76206.
PRIDEiO76206.

Expressioni

Gene expression databases

BgeeiFBgn0014930.
GenevisibleiO76206. DM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi7227.FBpp0081260.

Structurei

3D structure databases

ProteinModelPortaliO76206.
SMRiO76206. Positions 4-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3110. Eukaryota.
COG0196. LUCA.
GeneTreeiENSGT00390000015537.
InParanoidiO76206.
KOiK00861.
OMAiSLPYFCR.
OrthoDBiEOG091G0Z4E.
PhylomeDBiO76206.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiIPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF01687. Flavokinase. 1 hit.
[Graphical view]
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

O76206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQLPLFAG GEIVRGFGRG SKELGIPTAN FPLEVVKSLP ESLPTGAYYG
60 70 80 90 100
WANVDNGPVH KMVLSIGWNP FYNNKEKSVE THMLHDFNCD LYGQTLKICI
110 120 130 140 150
VGYLRPERSF DSLESLIAAI RGDIEQAKAF LDEADKAKLK EAPFFTEKLC

SSK
Length:153
Mass (Da):16,986
Last modified:November 1, 1998 - v1
Checksum:i56FF3B5C043C0D22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241L → M in AAL28446 (PubMed:12537569).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017096 Genomic DNA. Translation: AAC39087.1.
AE014297 Genomic DNA. Translation: AAF54164.1.
AY071393 mRNA. Translation: AAL49015.1.
AY060898 mRNA. Translation: AAL28446.1.
BT050515 mRNA. Translation: ACJ13222.1.
RefSeqiNP_001287218.1. NM_001300289.1.
NP_649749.2. NM_141492.3.
UniGeneiDm.1095.

Genome annotation databases

EnsemblMetazoaiFBtr0081763; FBpp0081260; FBgn0014930.
FBtr0339712; FBpp0308769; FBgn0014930.
GeneIDi40936.
KEGGidme:Dmel_CG2846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017096 Genomic DNA. Translation: AAC39087.1.
AE014297 Genomic DNA. Translation: AAF54164.1.
AY071393 mRNA. Translation: AAL49015.1.
AY060898 mRNA. Translation: AAL28446.1.
BT050515 mRNA. Translation: ACJ13222.1.
RefSeqiNP_001287218.1. NM_001300289.1.
NP_649749.2. NM_141492.3.
UniGeneiDm.1095.

3D structure databases

ProteinModelPortaliO76206.
SMRiO76206. Positions 4-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0081260.

Proteomic databases

PaxDbiO76206.
PRIDEiO76206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081763; FBpp0081260; FBgn0014930.
FBtr0339712; FBpp0308769; FBgn0014930.
GeneIDi40936.
KEGGidme:Dmel_CG2846.

Organism-specific databases

FlyBaseiFBgn0014930. CG2846.

Phylogenomic databases

eggNOGiKOG3110. Eukaryota.
COG0196. LUCA.
GeneTreeiENSGT00390000015537.
InParanoidiO76206.
KOiK00861.
OMAiSLPYFCR.
OrthoDBiEOG091G0Z4E.
PhylomeDBiO76206.

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.
ReactomeiR-DME-196843. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

GenomeRNAii40936.
PROiO76206.

Gene expression databases

BgeeiFBgn0014930.
GenevisibleiO76206. DM.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiIPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF01687. Flavokinase. 1 hit.
[Graphical view]
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIFK_DROME
AccessioniPrimary (citable) accession number: O76206
Secondary accession number(s): B6IDS5, Q95S97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.