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Protein
Submitted name:

Ornithine decarboxylase

Gene

ODC

Organism
Haemonchus contortus (Barber pole worm)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation

Enzyme and pathway databases

BRENDAi4.1.1.17. 2523.

Names & Taxonomyi

Protein namesi
Submitted name:
Ornithine decarboxylaseImported (EC:4.1.1.17Imported)
Gene namesi
Name:ODCImported
OrganismiHaemonchus contortus (Barber pole worm)Imported
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Structurei

3D structure databases

ProteinModelPortaliO76203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 283231Orn_Arg_deC_NInterPro annotationAdd
BLAST
Domaini288 – 406119Orn_DAP_Arg_deCInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMITQMELI GDSKVGIADG EVDALSMCRQ IARNYDKDNI DEALCWSTDV
60 70 80 90 100
VSTDSFVKRE LPMIEPFYAV KCNTDRVLVR TLAALGTGFD CASREEIDIV
110 120 130 140 150
MDLGVSAERI VYANPCKTRS FITHAKERNV SMMTFDSAEE LAKVAQLHPQ
160 170 180 190 200
AKMILRIAVS DPTARCPLNL KFGADPVKMA PQLLVHAQEL GVDVIGISFH
210 220 230 240 250
VGSGCNDPTA YREALAHARH LIELGRGLGL DMTLVDLGGG YPGTPQQTSF
260 270 280 290 300
EDIAAVIRSA VDEYLPPEFG VRLIAEPGRF FAAAPFTLVC NIIHATEVSA
310 320 330 340 350
EKITKRPEDV EERGFMYYVN DGVYGSFNCI LFDHVQPVGT PLFDEIAQEY
360 370 380 390 400
PSTIWGPTCD SLDKIEDQKL MRMMSVGEWI VYRNMGAYTC SASTTFNGFQ
410 420
RPNAIYMINR KNWARISTSP NV
Length:422
Mass (Da):46,739
Last modified:November 1, 1998 - v1
Checksum:i5F95A1137941AB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016891 mRNA. Translation: AAC27893.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016891 mRNA. Translation: AAC27893.1.

3D structure databases

ProteinModelPortaliO76203.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi4.1.1.17. 2523.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Haemonchus contortus: cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors."
    Klein R.D., Favreau M.A., Alexander-Bowman S.J., Nulf S.C., Vanover L., Winterrowd C.A., Yarlett N., Martinez M., Keithly J.S., Zantello M.R., Thomas E.M., Geary T.G.
    Exp. Parasitol. 87:171-184(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO76203_HAECO
AccessioniPrimary (citable) accession number: O76203
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.