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Protein

Protein ultraspiracle homolog

Gene

USP

Organism
Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ecdysone. May be an important modulator of insect metamorphosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi119 – 191Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
Zinc fingeri119 – 139NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri155 – 179NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ultraspiracle homolog
Alternative name(s):
Nuclear receptor subfamily 2 group B member 4
Gene namesi
Name:USP
Synonyms:NR2B4
OrganismiChoristoneura fumiferana (Spruce budworm moth) (Archips fumiferana)
Taxonomic identifieri7141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2366580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535851 – 472Protein ultraspiracle homologAdd BLAST472

Interactioni

Subunit structurei

Heterodimer of USP and ECR. Only the heterodimer is capable of high-affinity binding to ecdysone (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO76202.
SMRiO76202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 118ModulatingBy similarityAdd BLAST118
Regioni192 – 198Hinge7
Regioni198 – 472Ligand-bindingBy similarityAdd BLAST275

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri119 – 139NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri155 – 179NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVAKKDKP TMSVTALINW ARPAPPGPPQ PQSASPAPAA MLQQLPTQSM
60 70 80 90 100
QSLNHIPTVD CSLDMQWLNL EPGFMSPMSP PEMKPDTAML DGLRDDATSP
110 120 130 140 150
PNFKNYPPNH PLSGSKHLCS ICGDRASGKH YGVYSCEGCK GFFKRTVRKD
160 170 180 190 200
LSYACREERN CIIDKRQRNR CQYCRYQKCL ACGMKREAVQ EERQRNARGA
210 220 230 240 250
EDAHPSSSVQ VSDELSIERL TEMESLVADP SEEFQFLRVG PDSNVPPRYR
260 270 280 290 300
APVSSLCQIG NKQIAALVVW ARDIPHFGQL ELDDQVVLIK ASWNELLLFA
310 320 330 340 350
IAWRSMEYLE DERENGDGTR STTQPQLMCL MPGMTLHRNS AQQAGVGAIF
360 370 380 390 400
DRVLSELSLK MRTLRMDQAE YVALKAIVLL NPDVKGLKNR QEVDVLREKM
410 420 430 440 450
FSCLDDYCRR SRSNEEGRFA SLLLRLPALR SISLKSFEHL YFFHLVAEGS
460 470
ISGYIREALR NHAPPIDVNA MM
Length:472
Mass (Da):53,139
Last modified:November 1, 1998 - v1
Checksum:i837F22DCC366C479
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016368 mRNA. Translation: AAC31795.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016368 mRNA. Translation: AAC31795.1.

3D structure databases

ProteinModelPortaliO76202.
SMRiO76202.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2366580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUSP_CHOFU
AccessioniPrimary (citable) accession number: O76202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 12, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.