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Protein

Olfactory receptor 7A10

Gene

OR7A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127515-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A10
Alternative name(s):
OST027
Olfactory receptor OR19-18
Gene namesi
Name:OR7A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8356. OR7A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127515.
PharmGKBiPA32611.

Polymorphism and mutation databases

BioMutaiOR7A10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506441 – 309Olfactory receptor 7A10Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76100.
PRIDEiO76100.
TopDownProteomicsiO76100.

Expressioni

Gene expression databases

BgeeiENSG00000127515.
CleanExiHS_OR7A10.
ExpressionAtlasiO76100. baseline.
GenevisibleiO76100. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000248058.

Structurei

3D structure databases

ProteinModelPortaliO76100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO76100.
KOiK04257.
OMAiWNNTIIL.
OrthoDBiEOG091G0B53.
PhylomeDBiO76100.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSWNNTIIL EFLLLGISEE PELQAFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFVD ICFVSTTVPK MLVNIQTHNK VITYAGCITQ
110 120 130 140 150
MCFFLLFVGL DNFLLTVMAY DRFVAICHPL HYMVIMNPQL CGLLVLASWI
160 170 180 190 200
MSVLNSMLQS LMVLPLPFCT HMEIPHFFCE INQVVHLACS DTFLNDIVMY
210 220 230 240 250
FAVALLGGGP LTGILYSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FYGTCLGVYL SSAATHNSHT GAAASVMYTV VTPMLNPFIY SLRNKHIKGA

MKTFFRGKQ
Length:309
Mass (Da):34,406
Last modified:November 1, 1998 - v1
Checksum:i8761B3C97FE3ADB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70D → G in AAK95027 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053225151M → T.Corresponds to variant rs12972670dbSNPEnsembl.1
Natural variantiVAR_034254183Q → E.Corresponds to variant rs9305052dbSNPEnsembl.1
Natural variantiVAR_053226225I → L.Corresponds to variant rs11880955dbSNPEnsembl.1
Natural variantiVAR_053227273A → T.Corresponds to variant rs10221530dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA. Translation: AAC25627.1.
AF399542 Genomic DNA. Translation: AAK95027.1.
BK004222 Genomic DNA. Translation: DAA04620.1.
CCDSiCCDS32936.1.
RefSeqiNP_001005190.1. NM_001005190.1.
UniGeneiHs.553776.

Genome annotation databases

EnsembliENST00000248058; ENSP00000248058; ENSG00000127515.
GeneIDi390892.
KEGGihsa:390892.
UCSCiuc002mzx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA. Translation: AAC25627.1.
AF399542 Genomic DNA. Translation: AAK95027.1.
BK004222 Genomic DNA. Translation: DAA04620.1.
CCDSiCCDS32936.1.
RefSeqiNP_001005190.1. NM_001005190.1.
UniGeneiHs.553776.

3D structure databases

ProteinModelPortaliO76100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000248058.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR7A10.

Proteomic databases

PaxDbiO76100.
PRIDEiO76100.
TopDownProteomicsiO76100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248058; ENSP00000248058; ENSG00000127515.
GeneIDi390892.
KEGGihsa:390892.
UCSCiuc002mzx.1. human.

Organism-specific databases

CTDi390892.
GeneCardsiOR7A10.
HGNCiHGNC:8356. OR7A10.
neXtProtiNX_O76100.
OpenTargetsiENSG00000127515.
PharmGKBiPA32611.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO76100.
KOiK04257.
OMAiWNNTIIL.
OrthoDBiEOG091G0B53.
PhylomeDBiO76100.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127515-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7A10.
GenomeRNAii390892.
PROiO76100.

Gene expression databases

BgeeiENSG00000127515.
CleanExiHS_OR7A10.
ExpressionAtlasiO76100. baseline.
GenevisibleiO76100. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7AA_HUMAN
AccessioniPrimary (citable) accession number: O76100
Secondary accession number(s): Q6IFP0, Q96R97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.