ID   OR7C1_HUMAN             Reviewed;         320 AA.
AC   O76099; Q15621; Q6IFP2; Q96R94;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 186.
DE   RecName: Full=Olfactory receptor 7C1;
DE   AltName: Full=Olfactory receptor 7C4;
DE   AltName: Full=Olfactory receptor OR19-16;
DE   AltName: Full=Olfactory receptor TPCR86;
GN   Name=OR7C1; Synonyms=OR7C4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANT LYS-171.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, AND VARIANTS LYS-171 AND PRO-210.
RC   TISSUE=Testis;
RX   PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA   Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT   "Specific repertoire of olfactory receptor genes in the male germ cells of
RT   several mammalian species.";
RL   Genomics 39:239-246(1997).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7C1";
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DR   EMBL; AC005255; AAC25625.1; -; Genomic_DNA.
DR   EMBL; AF399546; AAK95031.1; -; Genomic_DNA.
DR   EMBL; X89676; CAA61823.1; -; mRNA.
DR   EMBL; BK004220; DAA04618.1; -; Genomic_DNA.
DR   CCDS; CCDS12317.1; -.
DR   PIR; S58004; S58004.
DR   RefSeq; NP_945182.1; NM_198944.1.
DR   RefSeq; XP_005259910.1; XM_005259853.3.
DR   AlphaFoldDB; O76099; -.
DR   SMR; O76099; -.
DR   BioGRID; 117779; 3.
DR   IntAct; O76099; 1.
DR   STRING; 9606.ENSP00000493026; -.
DR   GlyCosmos; O76099; 1 site, No reported glycans.
DR   GlyGen; O76099; 1 site.
DR   iPTMnet; O76099; -.
DR   PhosphoSitePlus; O76099; -.
DR   BioMuta; OR7C1; -.
DR   MassIVE; O76099; -.
DR   PaxDb; 9606-ENSP00000248073; -.
DR   PeptideAtlas; O76099; -.
DR   Antibodypedia; 59279; 57 antibodies from 18 providers.
DR   DNASU; 26664; -.
DR   Ensembl; ENST00000248073.2; ENSP00000248073.2; ENSG00000127530.4.
DR   Ensembl; ENST00000641666.2; ENSP00000493429.1; ENSG00000127530.4.
DR   Ensembl; ENST00000642000.1; ENSP00000493248.1; ENSG00000127530.4.
DR   Ensembl; ENST00000642030.1; ENSP00000493026.1; ENSG00000127530.4.
DR   GeneID; 26664; -.
DR   KEGG; hsa:26664; -.
DR   MANE-Select; ENST00000641666.2; ENSP00000493429.1; NM_001370485.4; NP_001357414.2.
DR   UCSC; uc010xnz.3; human.
DR   AGR; HGNC:8373; -.
DR   CTD; 26664; -.
DR   DisGeNET; 26664; -.
DR   GeneCards; OR7C1; -.
DR   HGNC; HGNC:8373; OR7C1.
DR   HPA; ENSG00000127530; Tissue enhanced (parathyroid).
DR   neXtProt; NX_O76099; -.
DR   OpenTargets; ENSG00000127530; -.
DR   PharmGKB; PA32624; -.
DR   VEuPathDB; HostDB:ENSG00000127530; -.
DR   eggNOG; ENOG502T9M8; Eukaryota.
DR   GeneTree; ENSGT00940000162084; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; O76099; -.
DR   OMA; KMEIPHF; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; O76099; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; O76099; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; O76099; -.
DR   BioGRID-ORCS; 26664; 7 hits in 746 CRISPR screens.
DR   ChiTaRS; OR7C1; human.
DR   GeneWiki; OR7C1; -.
DR   GenomeRNAi; 26664; -.
DR   Pharos; O76099; Tdark.
DR   PRO; PR:O76099; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O76099; Protein.
DR   Bgee; ENSG00000127530; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 83 other cell types or tissues.
DR   ExpressionAtlas; O76099; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR   CDD; cd15234; 7tmA_OR7-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF193; OLFACTORY RECEPTOR 7C1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O76099; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Olfactory receptor 7C1"
FT                   /id="PRO_0000150646"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         99
FT                   /note="S -> G (in dbSNP:rs17230134)"
FT                   /id="VAR_053232"
FT   VARIANT         126
FT                   /note="V -> I (in dbSNP:rs10415562)"
FT                   /id="VAR_024111"
FT   VARIANT         171
FT                   /note="E -> K (in dbSNP:rs10415312)"
FT                   /evidence="ECO:0000269|PubMed:12213199,
FT                   ECO:0000269|PubMed:9119360"
FT                   /id="VAR_053233"
FT   VARIANT         210
FT                   /note="S -> P (in dbSNP:rs16979912)"
FT                   /evidence="ECO:0000269|PubMed:9119360"
FT                   /id="VAR_024112"
FT   CONFLICT        247
FT                   /note="V -> L (in Ref. 3; CAA61823)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35519 MW;  BBDCC409721D70C4 CRC64;
     METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY
     FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY
     DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD
     LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST
     CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
     LGRLLSRATF FNGDITAGLS
//