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Protein

Olfactory receptor 7C1

Gene

OR7C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7C1
Alternative name(s):
Olfactory receptor 7C4
Olfactory receptor OR19-16
Olfactory receptor TPCR86
Gene namesi
Name:OR7C1
Synonyms:OR7C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127530.2.
HGNCiHGNC:8373. OR7C1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127530.
PharmGKBiPA32624.

Polymorphism and mutation databases

BioMutaiOR7C1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506461 – 320Olfactory receptor 7C1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76099.
PRIDEiO76099.

PTM databases

iPTMnetiO76099.
PhosphoSitePlusiO76099.

Expressioni

Gene expression databases

BgeeiENSG00000127530.
CleanExiHS_OR7C1.
ExpressionAtlasiO76099. baseline and differential.
GenevisibleiO76099. HS.

Organism-specific databases

HPAiHPA047127.

Interactioni

Protein-protein interaction databases

BioGridi117779. 1 interactor.
STRINGi9606.ENSP00000248073.

Structurei

3D structure databases

ProteinModelPortaliO76099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO76099.
KOiK04257.
OMAiKFITYAG.
OrthoDBiEOG091G0B53.
PhylomeDBiO76099.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ
110 120 130 140 150
IFFFTSFGCL DNLLLTVMAY DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC
160 170 180 190 200
ISVMGSLLET LTVLRLSFCT EMEIPHFFCD LLEVLKLACS DTFINNVVIY
210 220 230 240 250
FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST CGSHLSVVTL
260 270 280 290 300
FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
310 320
LGRLLSRATF FNGDITAGLS
Length:320
Mass (Da):35,519
Last modified:November 1, 1998 - v1
Checksum:iBBDCC409721D70C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247V → L in CAA61823 (PubMed:9119360).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05323299S → G. Corresponds to variant dbSNP:rs17230134Ensembl.1
Natural variantiVAR_024111126V → I. Corresponds to variant dbSNP:rs10415562Ensembl.1
Natural variantiVAR_053233171E → K2 PublicationsCorresponds to variant dbSNP:rs10415312Ensembl.1
Natural variantiVAR_024112210S → P1 PublicationCorresponds to variant dbSNP:rs16979912Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA. Translation: AAC25625.1.
AF399546 Genomic DNA. Translation: AAK95031.1.
X89676 mRNA. Translation: CAA61823.1.
BK004220 Genomic DNA. Translation: DAA04618.1.
CCDSiCCDS12317.1.
PIRiS58004.
RefSeqiNP_945182.1. NM_198944.1.
XP_005259910.1. XM_005259853.3.
UniGeneiHs.466053.

Genome annotation databases

EnsembliENST00000248073; ENSP00000248073; ENSG00000127530.
GeneIDi26664.
KEGGihsa:26664.
UCSCiuc010xnz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR7C1_HUMAN
AccessioniPrimary (citable) accession number: O76099
Secondary accession number(s): Q15621, Q6IFP2, Q96R94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families