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Protein

Olfactory receptor 7C1

Gene

OR7C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7C1
Alternative name(s):
Olfactory receptor 7C4
Olfactory receptor OR19-16
Olfactory receptor TPCR86
Gene namesi
Name:OR7C1
Synonyms:OR7C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8373. OR7C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32624.

Polymorphism and mutation databases

BioMutaiOR7C1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 7C1PRO_0000150646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76099.
PRIDEiO76099.

PTM databases

PhosphoSiteiO76099.

Expressioni

Gene expression databases

BgeeiO76099.
CleanExiHS_OR7C1.
GenevisibleiO76099. HS.

Organism-specific databases

HPAiHPA047127.

Interactioni

Protein-protein interaction databases

BioGridi117779. 1 interaction.
STRINGi9606.ENSP00000248073.

Structurei

3D structure databases

ProteinModelPortaliO76099.
SMRiO76099. Positions 22-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41548.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO76099.
KOiK04257.
OMAiTSEIQFI.
OrthoDBiEOG7HXCR6.
PhylomeDBiO76099.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ
110 120 130 140 150
IFFFTSFGCL DNLLLTVMAY DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC
160 170 180 190 200
ISVMGSLLET LTVLRLSFCT EMEIPHFFCD LLEVLKLACS DTFINNVVIY
210 220 230 240 250
FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST CGSHLSVVTL
260 270 280 290 300
FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
310 320
LGRLLSRATF FNGDITAGLS
Length:320
Mass (Da):35,519
Last modified:November 1, 1998 - v1
Checksum:iBBDCC409721D70C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471V → L in CAA61823 (PubMed:9119360).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991S → G.
Corresponds to variant rs17230134 [ dbSNP | Ensembl ].
VAR_053232
Natural varianti126 – 1261V → I.
Corresponds to variant rs10415562 [ dbSNP | Ensembl ].
VAR_024111
Natural varianti171 – 1711E → K.2 Publications
Corresponds to variant rs10415312 [ dbSNP | Ensembl ].
VAR_053233
Natural varianti210 – 2101S → P.1 Publication
Corresponds to variant rs16979912 [ dbSNP | Ensembl ].
VAR_024112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA. Translation: AAC25625.1.
AF399546 Genomic DNA. Translation: AAK95031.1.
X89676 mRNA. Translation: CAA61823.1.
BK004220 Genomic DNA. Translation: DAA04618.1.
CCDSiCCDS12317.1.
PIRiS58004.
RefSeqiNP_945182.1. NM_198944.1.
XP_005259910.1. XM_005259853.2.
UniGeneiHs.466053.

Genome annotation databases

EnsembliENST00000248073; ENSP00000248073; ENSG00000127530.
GeneIDi26664.
KEGGihsa:26664.
UCSCiuc010xnz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005255 Genomic DNA. Translation: AAC25625.1.
AF399546 Genomic DNA. Translation: AAK95031.1.
X89676 mRNA. Translation: CAA61823.1.
BK004220 Genomic DNA. Translation: DAA04618.1.
CCDSiCCDS12317.1.
PIRiS58004.
RefSeqiNP_945182.1. NM_198944.1.
XP_005259910.1. XM_005259853.2.
UniGeneiHs.466053.

3D structure databases

ProteinModelPortaliO76099.
SMRiO76099. Positions 22-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117779. 1 interaction.
STRINGi9606.ENSP00000248073.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO76099.

Polymorphism and mutation databases

BioMutaiOR7C1.

Proteomic databases

PaxDbiO76099.
PRIDEiO76099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248073; ENSP00000248073; ENSG00000127530.
GeneIDi26664.
KEGGihsa:26664.
UCSCiuc010xnz.2. human.

Organism-specific databases

CTDi26664.
GeneCardsiGC19M014909.
HGNCiHGNC:8373. OR7C1.
HPAiHPA047127.
neXtProtiNX_O76099.
PharmGKBiPA32624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41548.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO76099.
KOiK04257.
OMAiTSEIQFI.
OrthoDBiEOG7HXCR6.
PhylomeDBiO76099.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7C1.
GenomeRNAii26664.
NextBioi49023.
PROiO76099.

Gene expression databases

BgeeiO76099.
CleanExiHS_OR7C1.
GenevisibleiO76099. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT LYS-171.
  3. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, VARIANTS LYS-171 AND PRO-210.
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR7C1_HUMAN
AccessioniPrimary (citable) accession number: O76099
Secondary accession number(s): Q15621, Q6IFP2, Q96R94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.