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O76099

- OR7C1_HUMAN

UniProt

O76099 - OR7C1_HUMAN

Protein

Olfactory receptor 7C1

Gene

OR7C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 7C1
    Alternative name(s):
    Olfactory receptor 7C4
    Olfactory receptor OR19-16
    Olfactory receptor TPCR86
    Gene namesi
    Name:OR7C1
    Synonyms:OR7C4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8373. OR7C1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32624.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Olfactory receptor 7C1PRO_0000150646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76099.
    PRIDEiO76099.

    PTM databases

    PhosphoSiteiO76099.

    Expressioni

    Gene expression databases

    BgeeiO76099.
    CleanExiHS_OR7C1.
    GenevestigatoriO76099.

    Organism-specific databases

    HPAiHPA047127.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000248073.

    Structurei

    3D structure databases

    ProteinModelPortaliO76099.
    SMRiO76099. Positions 29-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41548.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiO76099.
    KOiK04257.
    OMAiTSEIQFI.
    OrthoDBiEOG7HXCR6.
    PhylomeDBiO76099.
    TreeFamiTF337210.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76099-1 [UniParc]FASTAAdd to Basket

    « Hide

    METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC    50
    SDSHLHTPMY FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ 100
    IFFFTSFGCL DNLLLTVMAY DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC 150
    ISVMGSLLET LTVLRLSFCT EMEIPHFFCD LLEVLKLACS DTFINNVVIY 200
    FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST CGSHLSVVTL 250
    FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA 300
    LGRLLSRATF FNGDITAGLS 320
    Length:320
    Mass (Da):35,519
    Last modified:November 1, 1998 - v1
    Checksum:iBBDCC409721D70C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471V → L in CAA61823. (PubMed:9119360)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti99 – 991S → G.
    Corresponds to variant rs17230134 [ dbSNP | Ensembl ].
    VAR_053232
    Natural varianti126 – 1261V → I.
    Corresponds to variant rs10415562 [ dbSNP | Ensembl ].
    VAR_024111
    Natural varianti171 – 1711E → K.2 Publications
    Corresponds to variant rs10415312 [ dbSNP | Ensembl ].
    VAR_053233
    Natural varianti210 – 2101S → P.1 Publication
    Corresponds to variant rs16979912 [ dbSNP | Ensembl ].
    VAR_024112

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005255 Genomic DNA. Translation: AAC25625.1.
    AF399546 Genomic DNA. Translation: AAK95031.1.
    X89676 mRNA. Translation: CAA61823.1.
    BK004220 Genomic DNA. Translation: DAA04618.1.
    CCDSiCCDS12317.1.
    PIRiS58004.
    RefSeqiNP_945182.1. NM_198944.1.
    XP_005259910.1. XM_005259853.1.
    UniGeneiHs.466053.

    Genome annotation databases

    EnsembliENST00000248073; ENSP00000248073; ENSG00000127530.
    GeneIDi26664.
    KEGGihsa:26664.
    UCSCiuc010xnz.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005255 Genomic DNA. Translation: AAC25625.1 .
    AF399546 Genomic DNA. Translation: AAK95031.1 .
    X89676 mRNA. Translation: CAA61823.1 .
    BK004220 Genomic DNA. Translation: DAA04618.1 .
    CCDSi CCDS12317.1.
    PIRi S58004.
    RefSeqi NP_945182.1. NM_198944.1.
    XP_005259910.1. XM_005259853.1.
    UniGenei Hs.466053.

    3D structure databases

    ProteinModelPortali O76099.
    SMRi O76099. Positions 29-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000248073.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O76099.

    Proteomic databases

    PaxDbi O76099.
    PRIDEi O76099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248073 ; ENSP00000248073 ; ENSG00000127530 .
    GeneIDi 26664.
    KEGGi hsa:26664.
    UCSCi uc010xnz.2. human.

    Organism-specific databases

    CTDi 26664.
    GeneCardsi GC19M014909.
    HGNCi HGNC:8373. OR7C1.
    HPAi HPA047127.
    neXtProti NX_O76099.
    PharmGKBi PA32624.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41548.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi O76099.
    KOi K04257.
    OMAi TSEIQFI.
    OrthoDBi EOG7HXCR6.
    PhylomeDBi O76099.
    TreeFami TF337210.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR7C1.
    GenomeRNAii 26664.
    NextBioi 49023.
    PROi O76099.

    Gene expression databases

    Bgeei O76099.
    CleanExi HS_OR7C1.
    Genevestigatori O76099.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT LYS-171.
    3. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
      Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
      Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, VARIANTS LYS-171 AND PRO-210.
      Tissue: Testis.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR7C1_HUMAN
    AccessioniPrimary (citable) accession number: O76099
    Secondary accession number(s): Q15621, Q6IFP2, Q96R94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3