Olfactory receptor 7C1 - Homo sapiens (Human)

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O76099 (OR7C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 118. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Olfactory receptor 7C1

Alternative name(s):
Olfactory receptor 7C4
Olfactory receptor OR19-16
Olfactory receptor TPCR86

Gene names

Name:	OR7C1
Synonyms:	OR7C4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC spermatogenesis Traceable author statement PubMed 9268701. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 9268701. Source: ProtInc olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 320

320

Olfactory receptor 7C1

PRO_0000150646

Regions

Topological domain

1 – 25

Extracellular Potential

Transmembrane

26 – 46

Helical; Name=1; Potential

Topological domain

47 – 54

Cytoplasmic Potential

Transmembrane

55 – 75

Helical; Name=2; Potential

Topological domain

76 – 99

Extracellular Potential

Transmembrane

100 – 120

Helical; Name=3; Potential

Topological domain

121 – 139

Cytoplasmic Potential

Transmembrane

140 – 160

Helical; Name=4; Potential

Topological domain

161 – 197

Extracellular Potential

Transmembrane

198 – 217

Helical; Name=5; Potential

Topological domain

218 – 237

Cytoplasmic Potential

Transmembrane

238 – 258

Helical; Name=6; Potential

Topological domain

259 – 271

Extracellular Potential

Transmembrane

272 – 292

Helical; Name=7; Potential

Topological domain

293 – 313

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

97 ↔ 189

By similarity

Natural variations

Natural variant

S → G.
Corresponds to variant rs17230134 [ dbSNP | Ensembl ].

VAR_053232

Natural variant

126

V → I.
Corresponds to variant rs10415562 [ dbSNP | Ensembl ].

VAR_024111

Natural variant

171

E → K. Ref.2 Ref.3
Corresponds to variant rs10415312 [ dbSNP | Ensembl ].

VAR_053233

Natural variant

210

S → P. Ref.3
Corresponds to variant rs16979912 [ dbSNP | Ensembl ].

VAR_024112

Experimental info

Sequence conflict

247

V → L in CAA61823. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

O76099 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: BBDCC409721D70C4
Show »

FASTA

320

35,519

        10         20         30         40         50         60 
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY 

        70         80         90        100        110        120 
FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY 

       130        140        150        160        170        180 
DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD 

       190        200        210        220        230        240 
LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST 

       250        260        270        280        290        300 
CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA 

       310        320 
LGRLLSRATF FNGDITAGLS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, VARIANT LYS-171.
[3]	"Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species." Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M. Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, VARIANTS LYS-171 AND PRO-210. Tissue: Testis.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005255 Genomic DNA. Translation: AAC25625.1. AF399546 Genomic DNA. Translation: AAK95031.1. X89676 mRNA. Translation: CAA61823.1. BK004220 Genomic DNA. Translation: DAA04618.1.
IPI	IPI00008839.
PIR	S58004.
RefSeq	NP_945182.1. NM_198944.1.
UniGene	Hs.466053.
3D structure databases
ProteinModelPortal	O76099.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000248073.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O76099.
Proteomic databases
PaxDb	O76099.
PRIDE	O76099.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248073; ENSP00000248073; ENSG00000127530.
GeneID	26664.
KEGG	hsa:26664.
UCSC	uc010xnz.2. human.
Organism-specific databases
CTD	26664.
GeneCards	GC19M014909.
HGNC	HGNC:8373. OR7C1.
HPA	HPA047127.
neXtProt	NX_O76099.
PharmGKB	PA32624.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41548.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	O76099.
KO	K04257.
OMA	TSEIQFI.
OrthoDB	EOG4W0XDJ.
PhylomeDB	O76099.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O76099.
CleanEx	HS_OR7C1.
Genevestigator	O76099.
GermOnline	ENSG00000127530. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26664.
NextBio	49023.

Entry information

Entry name

OR7C1_HUMAN

Accession

Primary (citable) accession number: O76099
Secondary accession number(s): Q15621, Q6IFP2, Q96R94

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents