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Protein

Cystatin-F

Gene

CST7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Reactive site1

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: ProtInc
  • endopeptidase inhibitor activity Source: ProtInc
  • protease binding Source: GO_Central

GO - Biological processi

  • immune response Source: ProtInc
  • negative regulation of cysteine-type endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077984-MONOMER.

Protein family/group databases

MEROPSiI25.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-F
Alternative name(s):
Cystatin-7
Cystatin-like metastasis-associated protein
Short name:
CMAP
Leukocystatin
Gene namesi
Name:CST7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:2479. CST7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8530.
OpenTargetsiENSG00000077984.
PharmGKBiPA26980.

Polymorphism and mutation databases

BioMutaiCST7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisCombined sourcesAdd BLAST19
ChainiPRO_000000664620 – 145Cystatin-FAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26Interchain (with C-63)1 Publication
Glycosylationi62N-linked (GlcNAc...)1 Publication1
Disulfide bondi63Interchain (with C-26)1 Publication
Disulfide bondi99 ↔ 1101 Publication
Glycosylationi115N-linked (GlcNAc...)1 Publication1
Disulfide bondi124 ↔ 1441 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO76096.
PaxDbiO76096.
PeptideAtlasiO76096.
PRIDEiO76096.

PTM databases

iPTMnetiO76096.
PhosphoSitePlusiO76096.

Expressioni

Tissue specificityi

Primarily expressed in peripheral blood cells and spleen.

Gene expression databases

BgeeiENSG00000077984.
CleanExiHS_CST7.
GenevisibleiO76096. HS.

Organism-specific databases

HPAiHPA040442.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CTSCP536342EBI-2807448,EBI-1047323

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114100. 8 interactors.
IntActiO76096. 2 interactors.
MINTiMINT-6179682.
STRINGi9606.ENSP00000420384.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 63Combined sources17
Beta strandi67 – 100Combined sources34
Helixi107 – 109Combined sources3
Turni116 – 118Combined sources3
Beta strandi121 – 131Combined sources11
Helixi132 – 134Combined sources3
Beta strandi136 – 145Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CH9X-ray2.10A20-145[»]
ProteinModelPortaliO76096.
SMRiO76096.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76096.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 85Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J26J. Eukaryota.
ENOG41121KX. LUCA.
GeneTreeiENSGT00860000133825.
HOGENOMiHOG000112134.
HOVERGENiHBG009556.
InParanoidiO76096.
KOiK13903.
OMAiDNCDFQT.
OrthoDBiEOG091G0TP1.
PhylomeDBiO76096.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAGTLLAF CCLVLSTTGG PSPDTCSQDL NSRVKPGFPK TIKTNDPGVL
60 70 80 90 100
QAARYSVEKF NNCTNDMFLF KESRITRALV QIVKGLKYML EVEIGRTTCK
110 120 130 140
KNQHLRLDDC DFQTNHTLKQ TLSCYSEVWV VPWLQHFEVP VLRCH
Length:145
Mass (Da):16,454
Last modified:November 1, 1998 - v1
Checksum:iB2BCC4F76857CB0F
GO

Sequence cautioni

The sequence AAH15507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP88827 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA34941 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB11886 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB75498 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031824 mRNA. Translation: AAC39788.1.
AF036342 mRNA. Translation: AAC35747.1.
AB029636 Genomic DNA. Translation: BAB11886.1. Different initiation.
AJ510167
, AJ510168, AJ510169, AJ510170 Genomic DNA. Translation: CAD52872.1.
AB015225 mRNA. Translation: BAA34941.1. Different initiation.
BT009825 mRNA. Translation: AAP88827.1. Different initiation.
CR541860 mRNA. Translation: CAG46658.1.
CR541878 mRNA. Translation: CAG46676.1.
AL035661 Genomic DNA. Translation: CAB75498.2. Different initiation.
BC015507 mRNA. Translation: AAH15507.1. Different initiation.
CCDSiCCDS13165.2.
RefSeqiNP_003641.3. NM_003650.3.
UniGeneiHs.143212.

Genome annotation databases

EnsembliENST00000480798; ENSP00000420384; ENSG00000077984.
GeneIDi8530.
KEGGihsa:8530.
UCSCiuc002wtx.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031824 mRNA. Translation: AAC39788.1.
AF036342 mRNA. Translation: AAC35747.1.
AB029636 Genomic DNA. Translation: BAB11886.1. Different initiation.
AJ510167
, AJ510168, AJ510169, AJ510170 Genomic DNA. Translation: CAD52872.1.
AB015225 mRNA. Translation: BAA34941.1. Different initiation.
BT009825 mRNA. Translation: AAP88827.1. Different initiation.
CR541860 mRNA. Translation: CAG46658.1.
CR541878 mRNA. Translation: CAG46676.1.
AL035661 Genomic DNA. Translation: CAB75498.2. Different initiation.
BC015507 mRNA. Translation: AAH15507.1. Different initiation.
CCDSiCCDS13165.2.
RefSeqiNP_003641.3. NM_003650.3.
UniGeneiHs.143212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CH9X-ray2.10A20-145[»]
ProteinModelPortaliO76096.
SMRiO76096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114100. 8 interactors.
IntActiO76096. 2 interactors.
MINTiMINT-6179682.
STRINGi9606.ENSP00000420384.

Protein family/group databases

MEROPSiI25.007.

PTM databases

iPTMnetiO76096.
PhosphoSitePlusiO76096.

Polymorphism and mutation databases

BioMutaiCST7.

Proteomic databases

EPDiO76096.
PaxDbiO76096.
PeptideAtlasiO76096.
PRIDEiO76096.

Protocols and materials databases

DNASUi8530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000480798; ENSP00000420384; ENSG00000077984.
GeneIDi8530.
KEGGihsa:8530.
UCSCiuc002wtx.2. human.

Organism-specific databases

CTDi8530.
DisGeNETi8530.
GeneCardsiCST7.
HGNCiHGNC:2479. CST7.
HPAiHPA040442.
MIMi603253. gene.
neXtProtiNX_O76096.
OpenTargetsiENSG00000077984.
PharmGKBiPA26980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J26J. Eukaryota.
ENOG41121KX. LUCA.
GeneTreeiENSGT00860000133825.
HOGENOMiHOG000112134.
HOVERGENiHBG009556.
InParanoidiO76096.
KOiK13903.
OMAiDNCDFQT.
OrthoDBiEOG091G0TP1.
PhylomeDBiO76096.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077984-MONOMER.

Miscellaneous databases

ChiTaRSiCST7. human.
EvolutionaryTraceiO76096.
GeneWikiiCST7_(gene).
GenomeRNAii8530.
PROiO76096.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077984.
CleanExiHS_CST7.
GenevisibleiO76096. HS.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTF_HUMAN
AccessioniPrimary (citable) accession number: O76096
Secondary accession number(s): Q6FH95, Q7Z4J8, Q9UED4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.