ID   JTB_HUMAN               Reviewed;         146 AA.
AC   O76095; O95442; Q6IB19; Q9P0Q4;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-JAN-2012, entry version 88.
DE   RecName: Full=Protein JTB;
DE   AltName: Full=Jumping translocation breakpoint protein;
DE   AltName: Full=Prostate androgen-regulated protein;
DE            Short=PAR protein;
DE   Flags: Precursor;
GN   Name=JTB; ORFNames=HSPC222;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   MEDLINE=99253649; PubMed=10321732; DOI=10.1038/sj.onc.1202510;
RA   Hatakeyama S., Osawa M., Omine M., Ishikawa F.;
RT   "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping
RT   translocation.";
RL   Oncogene 18:2085-2090(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Mammary cancer, and Prostatic carcinoma;
RX   MEDLINE=20227988; PubMed=10762645;
RA   Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M.;
RT   "PAR, a novel androgen regulated gene, ubiquitously expressed in
RT   normal and malignant cells.";
RL   Int. J. Oncol. 16:1055-1061(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Mei G., Yu W., Gibbs R.A.;
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Umbilical cord blood;
RX   MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for
RT   300 previously undefined genes expressed in CD34+ hematopoietic
RT   stem/progenitor cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Cervix, Lung, Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   TISSUE SPECIFICITY.
RX   PubMed=17369841; DOI=10.1038/sj.onc.1210423;
RA   Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K.,
RA   Shibanuma M.;
RT   "Characterization of Jumping translocation breakpoint (JTB) gene
RT   product isolated as a TGF-beta1-inducible clone involved in regulation
RT   of mitochondrial function, cell growth and cell death.";
RL   Oncogene 26:5991-6001(2007).
RN   [12]
RP   FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AURKA; AURKB AND
RP   BIRC5, SUBUNIT, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=21225229; DOI=10.3892/ijo.2011.900;
RA   Platica M., Ionescu A., Ivan E., Holland J.F., Mandeli J., Platica O.;
RT   "PAR, a protein involved in the cell cycle, is functionally related to
RT   chromosomal passenger proteins.";
RL   Int. J. Oncol. 38:777-785(2011).
RN   [13]
RP   STRUCTURE BY NMR OF 47-104.
RA   Rousseau F., Lingel A., Pan B., Fairbrother W.J., Bazan F.;
RT   "Solution structure of the extracellular domain of JTB.";
RL   Submitted (AUG-2010) to the PDB data bank.
CC   -!- FUNCTION: Required for normal cytokinesis during mitosis. Plays a
CC       role in the regulation of cell proliferation. May be a component
CC       of the chromosomal passenger complex (CPC), a complex that acts as
CC       a key regulator of mitosis. The CPC complex has essential
CC       functions at the centromere in ensuring correct chromosome
CC       alignment and segregation and is required for chromatin-induced
CC       microtubule stabilization and spindle assembly. Increases AURKB
CC       activity. Inhibits apoptosis induced by TGFB1 (By similarity).
CC       Overexpression induces swelling of mitochondria and reduces
CC       mitochondrial membrane potential (By similarity).
CC   -!- SUBUNIT: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a
CC       component of the CPC at least composed of BIRC5/survivin,
CC       CDCA8/borealin, INCENP and AURKB/Aurora-B.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential). Mitochondrion (By similarity). Cytoplasm.
CC       Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton,
CC       spindle. Note=Detected at the centrosome and along spindle fibers
CC       during prophase and metaphase. Detected at the midbody during
CC       telophase.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O76095-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O76095-2; Sequence=VSP_041400;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Expressed in all normal human
CC       tissues studied but overexpressed or underexpressed in many of
CC       their malignant counterparts.
CC   -!- INDUCTION: Protein levels increase during the S phase of the cell
CC       cycle, are highest during G2 and mitosis, and decrease to low
CC       levels at G1. Levels are lowest at the transition from G1 to S
CC       phase.
CC   -!- SIMILARITY: Belongs to the JTB family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB016492; BAA33735.1; -; Genomic_DNA.
DR   EMBL; AB016488; BAA33731.1; -; mRNA.
DR   EMBL; AB016493; BAA33736.1; -; Genomic_DNA.
DR   EMBL; AF115850; AAD09822.2; -; mRNA.
DR   EMBL; AF131797; AAD20045.1; -; mRNA.
DR   EMBL; AF151056; AAF36142.1; -; mRNA.
DR   EMBL; BT007285; AAP35949.1; -; mRNA.
DR   EMBL; CR456985; CAG33266.1; -; mRNA.
DR   EMBL; AK312106; BAG35042.1; -; mRNA.
DR   EMBL; AL358472; CAI14028.1; -; Genomic_DNA.
DR   EMBL; AL358472; CAI14029.1; -; Genomic_DNA.
DR   EMBL; AL358472; CAI14030.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53241.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53242.1; -; Genomic_DNA.
DR   EMBL; CH471121; EAW53244.1; -; Genomic_DNA.
DR   EMBL; BC000499; AAH00499.1; -; mRNA.
DR   EMBL; BC000996; AAH00996.1; -; mRNA.
DR   EMBL; BC001363; AAH01363.1; -; mRNA.
DR   EMBL; BC001667; AAH01667.1; -; mRNA.
DR   EMBL; BC004239; AAH04239.1; -; mRNA.
DR   EMBL; BC019277; AAH19277.1; -; mRNA.
DR   IPI; IPI00000912; -.
DR   IPI; IPI00008833; -.
DR   RefSeq; NP_006685.1; NM_006694.3.
DR   UniGene; Hs.6396; -.
DR   PDB; 2KJX; NMR; -; A=47-104.
DR   PDBsum; 2KJX; -.
DR   ProteinModelPortal; O76095; -.
DR   SMR; O76095; 46-104.
DR   IntAct; O76095; 5.
DR   STRING; O76095; -.
DR   PRIDE; O76095; -.
DR   Ensembl; ENST00000271843; ENSP00000271843; ENSG00000143543.
DR   Ensembl; ENST00000356648; ENSP00000349069; ENSG00000143543.
DR   Ensembl; ENST00000368589; ENSP00000357578; ENSG00000143543.
DR   Ensembl; ENST00000428469; ENSP00000395250; ENSG00000143543.
DR   Ensembl; ENST00000433648; ENSP00000413206; ENSG00000143543.
DR   GeneID; 10899; -.
DR   KEGG; hsa:10899; -.
DR   UCSC; uc001fds.1; human.
DR   CTD; 10899; -.
DR   GeneCards; GC01M153946; -.
DR   H-InvDB; HIX0001096; -.
DR   HGNC; HGNC:6201; JTB.
DR   HPA; HPA006514; -.
DR   MIM; 604671; gene.
DR   neXtProt; NX_O76095; -.
DR   PharmGKB; PA30003; -.
DR   eggNOG; prNOG14078; -.
DR   HOGENOM; HBG126257; -.
DR   HOVERGEN; HBG000952; -.
DR   InParanoid; O76095; -.
DR   OMA; TPECGST; -.
DR   OrthoDB; EOG49S67M; -.
DR   PhylomeDB; O76095; -.
DR   NextBio; 41391; -.
DR   ArrayExpress; O76095; -.
DR   Bgee; O76095; -.
DR   CleanEx; HS_JTB; -.
DR   Genevestigator; O76095; -.
DR   GermOnline; ENSG00000143543; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0005624; C:membrane fraction; TAS:ProtInc.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IDA:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0033205; P:cell cycle cytokinesis; IMP:UniProtKB.
DR   GO; GO:0007067; P:mitosis; IMP:UniProtKB.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
DR   InterPro; IPR008657; JTB.
DR   PANTHER; PTHR13041; JTB; 1.
DR   Pfam; PF05439; JTB; 1.
DR   ProDom; PD151382; JTB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Apoptosis; Cell cycle;
KW   Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Membrane;
KW   Mitochondrion; Mitosis; Polymorphism; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     30       Potential.
FT   CHAIN        31    146       Protein JTB.
FT                                /FTId=PRO_0000021535.
FT   TOPO_DOM     31    105       Extracellular (Potential).
FT   TRANSMEM    106    126       Helical; (Potential).
FT   TOPO_DOM    127    146       Cytoplasmic (Potential).
FT   VAR_SEQ       1     38       MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK ->
FT                                MAWGWHLSF (in isoform 2).
FT                                /FTId=VSP_041400.
FT   VARIANT      16     16       L -> F (in dbSNP:rs34686244).
FT                                /FTId=VAR_033994.
FT   TURN         49     51
FT   STRAND       54     61
FT   HELIX        65     70
FT   STRAND       80     85
FT   TURN         86     89
FT   STRAND       90     95
FT   HELIX        98    101
SQ   SEQUENCE   146 AA;  16358 MW;  CA7080543591C319 CRC64;
     MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC
     SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF
     ACLVIIRQRQ LDRKALEKVR KQIESI
//