Reviewed,
UniProtKB/Swiss-Prot O76095 (JTB_HUMAN)
Last modified
November 3, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein JTB Alternative name(s): Jumping translocation breakpoint protein Prostate androgen-regulated protein Short name=PAR protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 146 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Single-pass type I membrane protein Potential. |
| Tissue specificity | Expressed in all normal human tissues studied but overexpressed in most of their malignant counterparts. |
| Sequence similarities | Belongs to the JTB family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal Transmembrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc membrane fraction Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||
| Chain | 31 – 146 | 116 | Protein JTB | PRO_0000021535 | |||||
Regions | |||||||||
| Topological domain | 31 – 105 | 75 | Extracellular Potential | ||||||
| Transmembrane | 106 – 126 | 21 | Potential | ||||||
| Topological domain | 127 – 146 | 20 | Cytoplasmic Potential | ||||||
Natural variations | |||||||||
| Natural variant | 16 | 1 | L → F: dbSNP rs34686244. | VAR_033994 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation." Hatakeyama S., Osawa M., Omine M., Ishikawa F. Oncogene 18:2085-2090(1999) [PubMed: 10321732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [2] | "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells." Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M. Int. J. Oncol. 16:1055-1061(2000) [PubMed: 10762645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer and Prostatic carcinoma. |
| [3] | Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix, Lung and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB016492 Genomic DNA. Translation: BAA33735.1. AB016488 mRNA. Translation: BAA33731.1. AB016493 Genomic DNA. Translation: BAA33736.1. AF115850 mRNA. Translation: AAD09822.2. AF131797 mRNA. Translation: AAD20045.1. BC000499 mRNA. Translation: AAH00499.1. BC000996 mRNA. Translation: AAH00996.1. BC001363 mRNA. Translation: AAH01363.1. BC001667 mRNA. Translation: AAH01667.1. BC019277 mRNA. Translation: AAH19277.1. | |
| IPI | IPI00008833. |
| RefSeq | NP_006685.1. |
| UniGene | Hs.6396 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O76095. 1 interaction. |
| STRING | O76095. |
Proteomic databases | |
| PRIDE | O76095. |
Genome annotation databases | |
| Ensembl | ENST00000271843; ENSP00000271843; ENSG00000143543; Homo sapiens. [Genome view] ENST00000356648; ENSP00000349069; ENSG00000143543; Homo sapiens. [Genome view] ENST00000368589; ENSP00000357578; ENSG00000143543; Homo sapiens. [Genome view] ENST00000428469; ENSP00000395250; ENSG00000143543; Homo sapiens. [Genome view] ENST00000433648; ENSP00000413206; ENSG00000143543; Homo sapiens. [Genome view] |
| GeneID | 10899. |
| KEGG | hsa:10899. |
| UCSC | uc001fds.1. human. |
Organism-specific databases | |
| CTD | 10899. |
| GeneCards | GC01M152213. |
| HGNC | HGNC:6201. JTB. |
| HPA | HPA006514. |
| MIM | 604671. gene. |
| PharmGKB | PA30003. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O76095. |
| HOVERGEN | O76095. |
| OMA | TPECGST. |
Gene expression databases | |
| ArrayExpress | O76095. |
| Bgee | O76095. |
| CleanEx | HS_JTB. |
| Genevestigator | O76095. |
| GermOnline | ENSG00000143543. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008657. JTB. [Graphical view] |
| PANTHER | PTHR13041. JTB. 1 hit. |
| Pfam | PF05439. JTB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 41391. |
| SOURCE | Search... |
Entry information
| Entry name | JTB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O76095 Secondary accession number(s): O95442 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


