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Protein

Protein JTB

Gene

JTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. apoptotic mitochondrial changes Source: Ensembl
  2. cytokinesis Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB
  4. positive regulation of protein kinase activity Source: UniProtKB
  5. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Alternative name(s):
Jumping translocation breakpoint protein
Prostate androgen-regulated protein
Short name:
PAR protein
Gene namesi
Name:JTB
ORF Names:HSPC222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6201. JTB.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Mitochondrion By similarity. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle
Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 10575ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 14620CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. microtubule organizing center Source: UniProtKB-SubCell
  5. midbody Source: UniProtKB
  6. mitochondrion Source: UniProtKB-SubCell
  7. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 146116Protein JTBPRO_0000021535Add
BLAST

Proteomic databases

MaxQBiO76095.
PaxDbiO76095.
PRIDEiO76095.

PTM databases

PhosphoSiteiO76095.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.4 Publications

Inductioni

Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.1 Publication

Gene expression databases

BgeeiO76095.
CleanExiHS_JTB.
GenevestigatoriO76095.

Organism-specific databases

HPAiHPA006514.

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.1 Publication

Protein-protein interaction databases

BioGridi116105. 4 interactions.
IntActiO76095. 6 interactions.
MINTiMINT-8247506.
STRINGi9606.ENSP00000271843.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni49 – 513Combined sources
Beta strandi54 – 629Combined sources
Helixi65 – 706Combined sources
Helixi72 – 743Combined sources
Turni75 – 773Combined sources
Beta strandi79 – 857Combined sources
Turni86 – 894Combined sources
Beta strandi90 – 956Combined sources
Helixi98 – 1014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KJXNMR-A47-104[»]
ProteinModelPortaliO76095.
SMRiO76095. Positions 46-104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76095.

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296098.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO76095.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO76095.
TreeFamiTF316934.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O76095-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL
60 70 80 90 100
VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
MEQRLFWKFE GAVVCVALIF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,358
Last modified:November 1, 1998 - v1
Checksum:iCA7080543591C319
GO
Isoform 2 (identifier: O76095-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK → MAWGWHLSF

Show »
Length:117
Mass (Da):13,356
Checksum:i39BB62469FA5541B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → F.
Corresponds to variant rs34686244 [ dbSNP | Ensembl ].
VAR_033994

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838MLAGA…VQEEK → MAWGWHLSF in isoform 2. 2 PublicationsVSP_041400Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016492 Genomic DNA. Translation: BAA33735.1.
AB016488 mRNA. Translation: BAA33731.1.
AB016493 Genomic DNA. Translation: BAA33736.1.
AF115850 mRNA. Translation: AAD09822.2.
AF131797 mRNA. Translation: AAD20045.1.
AF151056 mRNA. Translation: AAF36142.1.
BT007285 mRNA. Translation: AAP35949.1.
CR456985 mRNA. Translation: CAG33266.1.
AK312106 mRNA. Translation: BAG35042.1.
AL358472 Genomic DNA. Translation: CAI14028.1.
AL358472 Genomic DNA. Translation: CAI14029.1.
AL358472 Genomic DNA. Translation: CAI14030.1.
CH471121 Genomic DNA. Translation: EAW53241.1.
CH471121 Genomic DNA. Translation: EAW53242.1.
CH471121 Genomic DNA. Translation: EAW53244.1.
BC000499 mRNA. Translation: AAH00499.1.
BC000996 mRNA. Translation: AAH00996.1.
BC001363 mRNA. Translation: AAH01363.1.
BC001667 mRNA. Translation: AAH01667.1.
BC004239 mRNA. Translation: AAH04239.1.
BC019277 mRNA. Translation: AAH19277.1.
CCDSiCCDS1057.1. [O76095-1]
RefSeqiNP_006685.1. NM_006694.3. [O76095-1]
UniGeneiHs.6396.

Genome annotation databases

EnsembliENST00000271843; ENSP00000271843; ENSG00000143543. [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543. [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543. [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543. [O76095-2]
GeneIDi10899.
KEGGihsa:10899.
UCSCiuc001fds.3. human. [O76095-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016492 Genomic DNA. Translation: BAA33735.1.
AB016488 mRNA. Translation: BAA33731.1.
AB016493 Genomic DNA. Translation: BAA33736.1.
AF115850 mRNA. Translation: AAD09822.2.
AF131797 mRNA. Translation: AAD20045.1.
AF151056 mRNA. Translation: AAF36142.1.
BT007285 mRNA. Translation: AAP35949.1.
CR456985 mRNA. Translation: CAG33266.1.
AK312106 mRNA. Translation: BAG35042.1.
AL358472 Genomic DNA. Translation: CAI14028.1.
AL358472 Genomic DNA. Translation: CAI14029.1.
AL358472 Genomic DNA. Translation: CAI14030.1.
CH471121 Genomic DNA. Translation: EAW53241.1.
CH471121 Genomic DNA. Translation: EAW53242.1.
CH471121 Genomic DNA. Translation: EAW53244.1.
BC000499 mRNA. Translation: AAH00499.1.
BC000996 mRNA. Translation: AAH00996.1.
BC001363 mRNA. Translation: AAH01363.1.
BC001667 mRNA. Translation: AAH01667.1.
BC004239 mRNA. Translation: AAH04239.1.
BC019277 mRNA. Translation: AAH19277.1.
CCDSiCCDS1057.1. [O76095-1]
RefSeqiNP_006685.1. NM_006694.3. [O76095-1]
UniGeneiHs.6396.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KJXNMR-A47-104[»]
ProteinModelPortaliO76095.
SMRiO76095. Positions 46-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116105. 4 interactions.
IntActiO76095. 6 interactions.
MINTiMINT-8247506.
STRINGi9606.ENSP00000271843.

PTM databases

PhosphoSiteiO76095.

Proteomic databases

MaxQBiO76095.
PaxDbiO76095.
PRIDEiO76095.

Protocols and materials databases

DNASUi10899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271843; ENSP00000271843; ENSG00000143543. [O76095-1]
ENST00000356648; ENSP00000349069; ENSG00000143543. [O76095-2]
ENST00000368589; ENSP00000357578; ENSG00000143543. [O76095-2]
ENST00000428469; ENSP00000395250; ENSG00000143543. [O76095-2]
GeneIDi10899.
KEGGihsa:10899.
UCSCiuc001fds.3. human. [O76095-1]

Organism-specific databases

CTDi10899.
GeneCardsiGC01M153946.
HGNCiHGNC:6201. JTB.
HPAiHPA006514.
MIMi604671. gene.
neXtProtiNX_O76095.
PharmGKBiPA30003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG296098.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO76095.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO76095.
TreeFamiTF316934.

Miscellaneous databases

ChiTaRSiJTB. human.
EvolutionaryTraceiO76095.
GeneWikiiJTB_(gene).
GenomeRNAii10899.
NextBioi41391.
PROiO76095.
SOURCEiSearch...

Gene expression databases

BgeeiO76095.
CleanExiHS_JTB.
GenevestigatoriO76095.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
    Hatakeyama S., Osawa M., Omine M., Ishikawa F.
    Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."
    Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M.
    Int. J. Oncol. 16:1055-1061(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Mammary cancer and Prostatic carcinoma.
  3. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix, Lung, Skin and Uterus.
  11. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
    Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
    Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
    Platica M., Ionescu A., Ivan E., Holland J.F., Mandeli J., Platica O.
    Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AURKA; AURKB AND BIRC5, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
  13. "The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold."
    Rousseau F., Pan B., Fairbrother W.J., Bazan J.F., Lingel A.
    J. Mol. Biol. 415:22-28(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 47-104.

Entry informationi

Entry nameiJTB_HUMAN
AccessioniPrimary (citable) accession number: O76095
Secondary accession number(s): O95442, Q6IB19, Q9P0Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.