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O76095

- JTB_HUMAN

UniProt

O76095 - JTB_HUMAN

Protein

Protein JTB

Gene

JTB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 By similarity. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential By similarity.By similarity

    GO - Molecular functioni

    1. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: Ensembl
    2. cytokinesis Source: UniProtKB
    3. mitotic nuclear division Source: UniProtKB
    4. positive regulation of protein kinase activity Source: UniProtKB
    5. regulation of cell proliferation Source: Ensembl

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein JTB
    Alternative name(s):
    Jumping translocation breakpoint protein
    Prostate androgen-regulated protein
    Short name:
    PAR protein
    Gene namesi
    Name:JTB
    ORF Names:HSPC222
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6201. JTB.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Mitochondrion By similarity. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle
    Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. microtubule organizing center Source: UniProtKB-SubCell
    5. midbody Source: UniProtKB
    6. mitochondrion Source: UniProtKB-SubCell
    7. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 146116Protein JTBPRO_0000021535Add
    BLAST

    Proteomic databases

    MaxQBiO76095.
    PaxDbiO76095.
    PRIDEiO76095.

    PTM databases

    PhosphoSiteiO76095.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.4 Publications

    Inductioni

    Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase.1 Publication

    Gene expression databases

    BgeeiO76095.
    CleanExiHS_JTB.
    GenevestigatoriO76095.

    Organism-specific databases

    HPAiHPA006514.

    Interactioni

    Subunit structurei

    Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.1 Publication

    Protein-protein interaction databases

    BioGridi116105. 4 interactions.
    IntActiO76095. 6 interactions.
    MINTiMINT-8247506.
    STRINGi9606.ENSP00000271843.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni49 – 513
    Beta strandi54 – 629
    Helixi65 – 706
    Helixi72 – 743
    Turni75 – 773
    Beta strandi79 – 857
    Turni86 – 894
    Beta strandi90 – 956
    Helixi98 – 1014

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KJXNMR-A47-104[»]
    ProteinModelPortaliO76095.
    SMRiO76095. Positions 46-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO76095.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 10575ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14620CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the JTB family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296098.
    HOGENOMiHOG000294204.
    HOVERGENiHBG000952.
    InParanoidiO76095.
    OMAiTPECGST.
    OrthoDBiEOG7SR4Q2.
    PhylomeDBiO76095.
    TreeFamiTF316934.

    Family and domain databases

    InterProiIPR008657. JTB.
    [Graphical view]
    PfamiPF05439. JTB. 1 hit.
    [Graphical view]
    ProDomiPD151382. JTB. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O76095-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL    50
    VEEFVVAEEC SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL 100
    MEQRLFWKFE GAVVCVALIF ACLVIIRQRQ LDRKALEKVR KQIESI 146
    Length:146
    Mass (Da):16,358
    Last modified:November 1, 1998 - v1
    Checksum:iCA7080543591C319
    GO
    Isoform 2 (identifier: O76095-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEK → MAWGWHLSF

    Show »
    Length:117
    Mass (Da):13,356
    Checksum:i39BB62469FA5541B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161L → F.
    Corresponds to variant rs34686244 [ dbSNP | Ensembl ].
    VAR_033994

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3838MLAGA…VQEEK → MAWGWHLSF in isoform 2. 2 PublicationsVSP_041400Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016492 Genomic DNA. Translation: BAA33735.1.
    AB016488 mRNA. Translation: BAA33731.1.
    AB016493 Genomic DNA. Translation: BAA33736.1.
    AF115850 mRNA. Translation: AAD09822.2.
    AF131797 mRNA. Translation: AAD20045.1.
    AF151056 mRNA. Translation: AAF36142.1.
    BT007285 mRNA. Translation: AAP35949.1.
    CR456985 mRNA. Translation: CAG33266.1.
    AK312106 mRNA. Translation: BAG35042.1.
    AL358472 Genomic DNA. Translation: CAI14028.1.
    AL358472 Genomic DNA. Translation: CAI14029.1.
    AL358472 Genomic DNA. Translation: CAI14030.1.
    CH471121 Genomic DNA. Translation: EAW53241.1.
    CH471121 Genomic DNA. Translation: EAW53242.1.
    CH471121 Genomic DNA. Translation: EAW53244.1.
    BC000499 mRNA. Translation: AAH00499.1.
    BC000996 mRNA. Translation: AAH00996.1.
    BC001363 mRNA. Translation: AAH01363.1.
    BC001667 mRNA. Translation: AAH01667.1.
    BC004239 mRNA. Translation: AAH04239.1.
    BC019277 mRNA. Translation: AAH19277.1.
    CCDSiCCDS1057.1. [O76095-1]
    RefSeqiNP_006685.1. NM_006694.3. [O76095-1]
    UniGeneiHs.6396.

    Genome annotation databases

    EnsembliENST00000271843; ENSP00000271843; ENSG00000143543. [O76095-1]
    ENST00000356648; ENSP00000349069; ENSG00000143543. [O76095-2]
    ENST00000368589; ENSP00000357578; ENSG00000143543. [O76095-2]
    ENST00000428469; ENSP00000395250; ENSG00000143543. [O76095-2]
    GeneIDi10899.
    KEGGihsa:10899.
    UCSCiuc001fds.3. human. [O76095-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016492 Genomic DNA. Translation: BAA33735.1 .
    AB016488 mRNA. Translation: BAA33731.1 .
    AB016493 Genomic DNA. Translation: BAA33736.1 .
    AF115850 mRNA. Translation: AAD09822.2 .
    AF131797 mRNA. Translation: AAD20045.1 .
    AF151056 mRNA. Translation: AAF36142.1 .
    BT007285 mRNA. Translation: AAP35949.1 .
    CR456985 mRNA. Translation: CAG33266.1 .
    AK312106 mRNA. Translation: BAG35042.1 .
    AL358472 Genomic DNA. Translation: CAI14028.1 .
    AL358472 Genomic DNA. Translation: CAI14029.1 .
    AL358472 Genomic DNA. Translation: CAI14030.1 .
    CH471121 Genomic DNA. Translation: EAW53241.1 .
    CH471121 Genomic DNA. Translation: EAW53242.1 .
    CH471121 Genomic DNA. Translation: EAW53244.1 .
    BC000499 mRNA. Translation: AAH00499.1 .
    BC000996 mRNA. Translation: AAH00996.1 .
    BC001363 mRNA. Translation: AAH01363.1 .
    BC001667 mRNA. Translation: AAH01667.1 .
    BC004239 mRNA. Translation: AAH04239.1 .
    BC019277 mRNA. Translation: AAH19277.1 .
    CCDSi CCDS1057.1. [O76095-1 ]
    RefSeqi NP_006685.1. NM_006694.3. [O76095-1 ]
    UniGenei Hs.6396.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KJX NMR - A 47-104 [» ]
    ProteinModelPortali O76095.
    SMRi O76095. Positions 46-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116105. 4 interactions.
    IntActi O76095. 6 interactions.
    MINTi MINT-8247506.
    STRINGi 9606.ENSP00000271843.

    PTM databases

    PhosphoSitei O76095.

    Proteomic databases

    MaxQBi O76095.
    PaxDbi O76095.
    PRIDEi O76095.

    Protocols and materials databases

    DNASUi 10899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271843 ; ENSP00000271843 ; ENSG00000143543 . [O76095-1 ]
    ENST00000356648 ; ENSP00000349069 ; ENSG00000143543 . [O76095-2 ]
    ENST00000368589 ; ENSP00000357578 ; ENSG00000143543 . [O76095-2 ]
    ENST00000428469 ; ENSP00000395250 ; ENSG00000143543 . [O76095-2 ]
    GeneIDi 10899.
    KEGGi hsa:10899.
    UCSCi uc001fds.3. human. [O76095-1 ]

    Organism-specific databases

    CTDi 10899.
    GeneCardsi GC01M153946.
    HGNCi HGNC:6201. JTB.
    HPAi HPA006514.
    MIMi 604671. gene.
    neXtProti NX_O76095.
    PharmGKBi PA30003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296098.
    HOGENOMi HOG000294204.
    HOVERGENi HBG000952.
    InParanoidi O76095.
    OMAi TPECGST.
    OrthoDBi EOG7SR4Q2.
    PhylomeDBi O76095.
    TreeFami TF316934.

    Miscellaneous databases

    EvolutionaryTracei O76095.
    GeneWikii JTB_(gene).
    GenomeRNAii 10899.
    NextBioi 41391.
    PROi O76095.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76095.
    CleanExi HS_JTB.
    Genevestigatori O76095.

    Family and domain databases

    InterProi IPR008657. JTB.
    [Graphical view ]
    Pfami PF05439. JTB. 1 hit.
    [Graphical view ]
    ProDomi PD151382. JTB. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
      Hatakeyama S., Osawa M., Omine M., Ishikawa F.
      Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."
      Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M.
      Int. J. Oncol. 16:1055-1061(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Mammary cancer and Prostatic carcinoma.
    3. Mei G., Yu W., Gibbs R.A.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Umbilical cord blood.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Tongue.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cervix, Lung, Skin and Uterus.
    11. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
      Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
      Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    12. "PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
      Platica M., Ionescu A., Ivan E., Holland J.F., Mandeli J., Platica O.
      Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AURKA; AURKB AND BIRC5, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
    13. "The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold."
      Rousseau F., Pan B., Fairbrother W.J., Bazan J.F., Lingel A.
      J. Mol. Biol. 415:22-28(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 47-104.

    Entry informationi

    Entry nameiJTB_HUMAN
    AccessioniPrimary (citable) accession number: O76095
    Secondary accession number(s): O95442, Q6IB19, Q9P0Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3