Reviewed, UniProtKB/Swiss-Prot O76095 (JTB_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein JTB
Alternative name(s):
    Jumping translocation breakpoint protein
    Prostate androgen-regulated protein
      Short name=PAR protein

Gene names

Name:

JTB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in all normal human tissues studied but overexpressed in most of their malignant counterparts.
Sequence similarities	Belongs to the JTB family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc membrane fraction Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 146	116	Protein JTB		PRO_0000021535
Regions
	Topological domain	31 – 105	75	Extracellular Potential
	Transmembrane	106 – 126	21	Potential
	Topological domain	127 – 146	20	Cytoplasmic Potential
Natural variations
	Natural variant	16	1	L → F: dbSNP rs34686244.		VAR_033994

Sequences

	Sequence		Length	Mass (Da)
	O76095-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: CA7080543591C319	FASTA	146	16,358
	10 20 30 40 50 60 MLAGAGRPGL PQGRHLCWLL CAFTLKLCQA EAPVQEEKLS ASTSNLPCWL VEEFVVAEEC 70 80 90 100 110 120 SPCSNFRAKT TPECGPTGYV EKITCSSSKR NEFKSCRSAL MEQRLFWKFE GAVVCVALIF 130 140 ACLVIIRQRQ LDRKALEKVR KQIESI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation." Hatakeyama S., Osawa M., Omine M., Ishikawa F. Oncogene 18:2085-2090(1999) [PubMed: 10321732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells." Platica O., Chen S., Ivan E., Lopingco M.C., Holland J.F., Platica M. Int. J. Oncol. 16:1055-1061(2000) [PubMed: 10762645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer and Prostatic carcinoma.
[3]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix, Lung and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB016492 Genomic DNA. Translation: BAA33735.1. AB016488 mRNA. Translation: BAA33731.1. AB016493 Genomic DNA. Translation: BAA33736.1. AF115850 mRNA. Translation: AAD09822.2. AF131797 mRNA. Translation: AAD20045.1. BC000499 mRNA. Translation: AAH00499.1. BC000996 mRNA. Translation: AAH00996.1. BC001363 mRNA. Translation: AAH01363.1. BC001667 mRNA. Translation: AAH01667.1. BC019277 mRNA. Translation: AAH19277.1.
IPI	IPI00008833.
RefSeq	NP_006685.1.
UniGene	Hs.6396
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O76095. 1 interaction.
STRING	O76095.
Proteomic databases
PRIDE	O76095.
Genome annotation databases
Ensembl	ENST00000271843; ENSP00000271843; ENSG00000143543; Homo sapiens. [Genome view] ENST00000356648; ENSP00000349069; ENSG00000143543; Homo sapiens. [Genome view] ENST00000368589; ENSP00000357578; ENSG00000143543; Homo sapiens. [Genome view] ENST00000428469; ENSP00000395250; ENSG00000143543; Homo sapiens. [Genome view] ENST00000433648; ENSP00000413206; ENSG00000143543; Homo sapiens. [Genome view]
GeneID	10899.
KEGG	hsa:10899.
UCSC	uc001fds.1. human.
Organism-specific databases
CTD	10899.
GeneCards	GC01M152213.
HGNC	HGNC:6201. JTB.
HPA	HPA006514.
MIM	604671. gene.
PharmGKB	PA30003.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O76095.
HOVERGEN	O76095.
OMA	TPECGST.
Gene expression databases
ArrayExpress	O76095.
Bgee	O76095.
CleanEx	HS_JTB.
Genevestigator	O76095.
GermOnline	ENSG00000143543. Homo sapiens.
Family and domain databases
InterPro	IPR008657. JTB. [Graphical view]
PANTHER	PTHR13041. JTB. 1 hit.
Pfam	PF05439. JTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	41391.
SOURCE	Search...

Entry information

Entry name

JTB_HUMAN

Accession

Primary (citable) accession number: O76095
Secondary accession number(s): O95442

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.