##gff-version 3 O76094 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.6,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:22223895,PMID:22814378 O76094 UniProtKB Chain 2 671 . . . ID=PRO_0000135234;Note=Signal recognition particle subunit SRP72 O76094 UniProtKB Repeat 11 44 . . . Note=TPR 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00339 O76094 UniProtKB Repeat 109 142 . . . Note=TPR 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00339 O76094 UniProtKB Repeat 226 259 . . . Note=TPR 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00339 O76094 UniProtKB Repeat 406 439 . . . Note=TPR 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00339 O76094 UniProtKB Repeat 447 480 . . . Note=TPR 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00339 O76094 UniProtKB Region 9 163 . . . Note=Required for interaction with SRP68;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16672232,ECO:0000269|PubMed:28369529;Dbxref=PMID:16672232,PMID:28369529 O76094 UniProtKB Region 379 509 . . . Note=Required for the interaction with the SRP68/7SL RNA complex;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P33731 O76094 UniProtKB Region 532 671 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O76094 UniProtKB Region 545 617 . . . Note=RNA-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Compositional bias 564 585 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O76094 UniProtKB Compositional bias 603 644 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O76094 UniProtKB Compositional bias 657 671 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O76094 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|Ref.6,ECO:0007744|PubMed:22223895,ECO:0007744|PubMed:22814378;Dbxref=PMID:22223895,PMID:22814378 O76094 UniProtKB Modified residue 571 571 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18691976,ECO:0007744|PubMed:23186163;Dbxref=PMID:18691976,PMID:23186163 O76094 UniProtKB Modified residue 618 618 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:24275569 O76094 UniProtKB Modified residue 630 630 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O76094 UniProtKB Modified residue 635 635 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O76094 UniProtKB Cross-link 391 391 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 O76094 UniProtKB Cross-link 391 391 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:28112733 O76094 UniProtKB Alternative sequence 215 275 . . . ID=VSP_045576;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 O76094 UniProtKB Natural variant 207 207 . . . ID=VAR_068522;Note=In BMFS1%3B affects protein localization to ER. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22541560;Dbxref=dbSNP:rs387907189,PMID:22541560 O76094 UniProtKB Mutagenesis 11 44 . . . Note=Loss of interaction with SRP68. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 44 44 . . . Note=Reduced interaction with SRP68. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 45 45 . . . Note=Reduced interaction with SRP68. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 53 53 . . . Note=Reduced interaction with SRP68. Diminished localization to endoplasmic reticulum. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 56 56 . . . Note=Loss of interaction with SRP72%3B when associated with A-598 in SRP68. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27899666;Dbxref=PMID:27899666 O76094 UniProtKB Mutagenesis 86 86 . . . Note=Loss of interaction with SRP68. Diminished localization to endoplasmic reticulum. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 113 131 . . . Note=Loss of interaction with SRP68. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 132 165 . . . Note=Loss of interaction with SRP68. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 136 137 . . . Note=Stronger interaction with SRP68. VR->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28369529;Dbxref=PMID:28369529 O76094 UniProtKB Mutagenesis 553 558 . . . Note=Loss of RNA binding. KKKKKK->AAAAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 555 556 . . . Note=Diminished RNA binding. KK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 577 578 . . . Note=Loss of RNA binding. WL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 579 580 . . . Note=Diminished RNA binding. PM->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 579 579 . . . Note=Strongly reduced RNA binding. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 580 580 . . . Note=Does not affect RNA binding. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 581 582 . . . Note=Diminished RNA binding. RE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 583 584 . . . Note=Loss of RNA binding. RS->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 585 586 . . . Note=Diminished RNA binding. YY->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 587 588 . . . Note=No impact on RNA binding. RG->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Mutagenesis 589 590 . . . Note=No impact on RNA binding. RK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21073748;Dbxref=PMID:21073748 O76094 UniProtKB Sequence conflict 23 23 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 O76094 UniProtKB Helix 11 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 27 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 45 57 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 61 70 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 72 75 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 81 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 94 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 109 121 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 125 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 144 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M72 O76094 UniProtKB Helix 563 566 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M73 O76094 UniProtKB Turn 567 570 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M73 O76094 UniProtKB Turn 580 582 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M73 O76094 UniProtKB Helix 590 602 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5M73