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O76094

- SRP72_HUMAN

UniProt

O76094 - SRP72_HUMAN

Protein

Signal recognition particle subunit SRP72

Gene

SRP72

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

    GO - Molecular functioni

    1. 7S RNA binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. signal recognition particle binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. response to drug Source: UniProtKB
    4. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    5. translation Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Protein family/group databases

    TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal recognition particle subunit SRP72
    Short name:
    SRP72
    Alternative name(s):
    Signal recognition particle 72 kDa protein
    Gene namesi
    Name:SRP72
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11303. SRP72.

    Subcellular locationi

    Cytoplasm 1 Publication. Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endoplasmic reticulum Source: UniProtKB
    3. signal recognition particle, endoplasmic reticulum targeting Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Signal recognition particle

    Pathology & Biotechi

    Involvement in diseasei

    Bone marrow failure syndrome 1 (BMFS1) [MIM:614675]: An autosomal dominant disease characterized by aplastic anemia and myelodysplasia resulting from bone marrow failure. Aplastic anemia is a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Myelodysplasia is a clonal hematopoietic stem cell disorder in which immature cells in the bone marrow become malformed and dysfunctional.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti207 – 2071R → H in BMFS1; affects protein localization to ER. 1 Publication
    VAR_068522

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614675. phenotype.
    Orphaneti314399. Autosomal dominant aplasia and myelodysplasia.
    PharmGKBiPA36127.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 671670Signal recognition particle subunit SRP72PRO_0000135234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei571 – 5711Phosphothreonine1 Publication
    Modified residuei618 – 6181Phosphothreonine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO76094.
    PaxDbiO76094.
    PeptideAtlasiO76094.
    PRIDEiO76094.

    PTM databases

    PhosphoSiteiO76094.

    Expressioni

    Gene expression databases

    ArrayExpressiO76094.
    BgeeiO76094.
    CleanExiHS_SRP72.
    GenevestigatoriO76094.

    Organism-specific databases

    HPAiHPA034621.

    Interactioni

    Subunit structurei

    Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

    Protein-protein interaction databases

    BioGridi112609. 18 interactions.
    IntActiO76094. 8 interactions.
    MINTiMINT-1197309.
    STRINGi9606.ENSP00000342181.

    Structurei

    3D structure databases

    ProteinModelPortaliO76094.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 4434TPR 1Add
    BLAST
    Repeati109 – 14234TPR 2Add
    BLAST
    Repeati226 – 25934TPR 3Add
    BLAST
    Repeati406 – 43934TPR 4Add
    BLAST
    Repeati447 – 48034TPR 5Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi552 – 56110Poly-Lys
    Compositional biasi662 – 6654Poly-Lys

    Domaini

    The C-terminus is essential for the interaction with the SRP68/7S RNA complex.By similarity

    Sequence similaritiesi

    Belongs to the SRP72 family.Curated
    Contains 5 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG263236.
    HOGENOMiHOG000006745.
    HOVERGENiHBG059920.
    InParanoidiO76094.
    KOiK03108.
    OMAiIGQGQLS.
    OrthoDBiEOG7RFTH7.
    PhylomeDBiO76094.
    TreeFamiTF106250.

    Family and domain databases

    Gene3Di1.25.40.10. 4 hits.
    InterProiIPR013699. Signal_recog_part_SRP72_RNA-bd.
    IPR026270. SRP72.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR14094. PTHR14094. 1 hit.
    PfamiPF08492. SRP72. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF13174. TPR_6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038922. SRP72. 1 hit.
    PROSITEiPS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O76094-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC    50
    KVVCLIQNGS FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT 100
    IESANQQTDK LKELYGQVLY RLERYDECLA VYRDLVRNSQ DDYDEERKTN 150
    LSAVVAAQSN WEKVVPENLG LQEGTHELCY NTACALIGQG QLNQAMKILQ 200
    KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG RTEEALQLYN 250
    QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK 300
    KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR 350
    EKQHTKAIEL LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE 400
    ELKHKPGMVS ALVTMYSHEE DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI 450
    REAANFKLKY GRKKEAISDL QQLWKQNPKD IHTLAQLISA YSLVDPEKAK 500
    ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD SQPKEQGQGD 550
    LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK 600
    GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA 650
    GAPATKKKQQ QKKKKGGKGG W 671
    Length:671
    Mass (Da):74,606
    Last modified:January 23, 2007 - v3
    Checksum:iCC0BA17AC52E3613
    GO
    Isoform 2 (identifier: O76094-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         215-275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:610
    Mass (Da):67,879
    Checksum:i6351C7451A38ECEC
    GO

    Sequence cautioni

    The sequence CAD97950.1 differs from that shown. Reason: Frameshift at position 565.
    The sequence CAD97950.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231Q → R in CAD97950. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti207 – 2071R → H in BMFS1; affects protein localization to ER. 1 Publication
    VAR_068522

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei215 – 27561Missing in isoform 2. 1 PublicationVSP_045576Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077019 mRNA. Translation: AAC27324.1.
    AF069765 mRNA. Translation: AAC97490.1.
    BX537991 mRNA. Translation: CAD97950.1. Sequence problems.
    AC114766 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05498.1.
    CCDSiCCDS3506.1. [O76094-1]
    CCDS58898.1. [O76094-2]
    RefSeqiNP_001254651.1. NM_001267722.1. [O76094-2]
    NP_008878.3. NM_006947.3. [O76094-1]
    UniGeneiHs.237825.

    Genome annotation databases

    EnsembliENST00000342756; ENSP00000342181; ENSG00000174780. [O76094-1]
    ENST00000510663; ENSP00000424576; ENSG00000174780. [O76094-2]
    GeneIDi6731.
    KEGGihsa:6731.
    UCSCiuc003hbv.3. human. [O76094-1]
    uc010ihe.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Signal recognition particle entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077019 mRNA. Translation: AAC27324.1 .
    AF069765 mRNA. Translation: AAC97490.1 .
    BX537991 mRNA. Translation: CAD97950.1 . Sequence problems.
    AC114766 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05498.1 .
    CCDSi CCDS3506.1. [O76094-1 ]
    CCDS58898.1. [O76094-2 ]
    RefSeqi NP_001254651.1. NM_001267722.1. [O76094-2 ]
    NP_008878.3. NM_006947.3. [O76094-1 ]
    UniGenei Hs.237825.

    3D structure databases

    ProteinModelPortali O76094.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112609. 18 interactions.
    IntActi O76094. 8 interactions.
    MINTi MINT-1197309.
    STRINGi 9606.ENSP00000342181.

    Protein family/group databases

    TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

    PTM databases

    PhosphoSitei O76094.

    Proteomic databases

    MaxQBi O76094.
    PaxDbi O76094.
    PeptideAtlasi O76094.
    PRIDEi O76094.

    Protocols and materials databases

    DNASUi 6731.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342756 ; ENSP00000342181 ; ENSG00000174780 . [O76094-1 ]
    ENST00000510663 ; ENSP00000424576 ; ENSG00000174780 . [O76094-2 ]
    GeneIDi 6731.
    KEGGi hsa:6731.
    UCSCi uc003hbv.3. human. [O76094-1 ]
    uc010ihe.3. human.

    Organism-specific databases

    CTDi 6731.
    GeneCardsi GC04P057334.
    HGNCi HGNC:11303. SRP72.
    HPAi HPA034621.
    MIMi 602122. gene.
    614675. phenotype.
    neXtProti NX_O76094.
    Orphaneti 314399. Autosomal dominant aplasia and myelodysplasia.
    PharmGKBi PA36127.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263236.
    HOGENOMi HOG000006745.
    HOVERGENi HBG059920.
    InParanoidi O76094.
    KOi K03108.
    OMAi IGQGQLS.
    OrthoDBi EOG7RFTH7.
    PhylomeDBi O76094.
    TreeFami TF106250.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    ChiTaRSi SRP72. human.
    GenomeRNAii 6731.
    NextBioi 26258.
    PROi O76094.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O76094.
    Bgeei O76094.
    CleanExi HS_SRP72.
    Genevestigatori O76094.

    Family and domain databases

    Gene3Di 1.25.40.10. 4 hits.
    InterProi IPR013699. Signal_recog_part_SRP72_RNA-bd.
    IPR026270. SRP72.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR14094. PTHR14094. 1 hit.
    Pfami PF08492. SRP72. 1 hit.
    PF00515. TPR_1. 1 hit.
    PF13174. TPR_6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038922. SRP72. 1 hit.
    PROSITEi PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein SRP72 sequence of human signal recognition particle."
      Gowda K., Zwieb C.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Sequence of human signal recognition particle (SRP) 72."
      Utz P.J., Hottelet M., Miller I.J., Anderson P.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Esophageal carcinoma.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-20; 63-84; 113-121; 148-163; 242-275; 288-297; 302-324; 326-350; 357-376; 465-475; 480-498; 516-531 AND 601-617, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-571, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-618, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia."
      Kirwan M., Walne A.J., Plagnol V., Velangi M., Ho A., Hossain U., Vulliamy T., Dokal I.
      Am. J. Hum. Genet. 90:888-892(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT BMFS1 HIS-207, SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT BMFS1 HIS-207.

    Entry informationi

    Entry nameiSRP72_HUMAN
    AccessioniPrimary (citable) accession number: O76094
    Secondary accession number(s): G5E9Z8, Q7Z3C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3