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Protein

Signal recognition particle subunit SRP72

Gene

SRP72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

GO - Molecular functioni

  • 7S RNA binding Source: CAFA
  • RNA binding Source: UniProtKB
  • signal recognition particle binding Source: UniProtKB
  • TPR domain binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP72
Short name:
SRP72
Alternative name(s):
Signal recognition particle 72 kDa protein
Gene namesi
Name:SRP72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000174780.15.
HGNCiHGNC:11303. SRP72.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Signal recognition particle

Pathology & Biotechi

Involvement in diseasei

Bone marrow failure syndrome 1 (BMFS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by aplastic anemia and myelodysplasia resulting from bone marrow failure. Aplastic anemia is a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Myelodysplasia is a clonal hematopoietic stem cell disorder in which immature cells in the bone marrow become malformed and dysfunctional.
See also OMIM:614675
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068522207R → H in BMFS1; affects protein localization to ER. 1 PublicationCorresponds to variant dbSNP:rs387907189Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6731.
MalaCardsiSRP72.
MIMi614675. phenotype.
OpenTargetsiENSG00000174780.
Orphaneti314399. Autosomal dominant aplasia and myelodysplasia.
PharmGKBiPA36127.

Polymorphism and mutation databases

BioMutaiSRP72.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001352342 – 671Signal recognition particle subunit SRP72Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei571PhosphothreonineCombined sources1
Modified residuei618PhosphothreonineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO76094.
PaxDbiO76094.
PeptideAtlasiO76094.
PRIDEiO76094.

PTM databases

iPTMnetiO76094.
PhosphoSitePlusiO76094.
SwissPalmiO76094.

Expressioni

Gene expression databases

BgeeiENSG00000174780.
CleanExiHS_SRP72.
ExpressionAtlasiO76094. baseline and differential.
GenevisibleiO76094. HS.

Organism-specific databases

HPAiHPA034621.

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

GO - Molecular functioni

  • TPR domain binding Source: CAFA

Protein-protein interaction databases

BioGridi112609. 55 interactors.
IntActiO76094. 30 interactors.
MINTiMINT-1197309.
STRINGi9606.ENSP00000342181.

Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 23Combined sources13
Helixi27 – 40Combined sources14
Helixi45 – 57Combined sources13
Helixi61 – 70Combined sources10
Helixi72 – 75Combined sources4
Helixi81 – 90Combined sources10
Helixi94 – 102Combined sources9
Helixi109 – 121Combined sources13
Helixi125 – 138Combined sources14
Helixi144 – 158Combined sources15
Helixi563 – 566Combined sources4
Turni567 – 570Combined sources4
Turni580 – 582Combined sources3
Helixi590 – 602Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5M72X-ray1.60A10-166[»]
5M73X-ray3.40D/H513-662[»]
5WRVX-ray1.70B1-163[»]
5WRWX-ray2.91A/B/C/D/E/F1-163[»]
ProteinModelPortaliO76094.
SMRiO76094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati109 – 142TPR 2Add BLAST34
Repeati226 – 259TPR 3Add BLAST34
Repeati406 – 439TPR 4Add BLAST34
Repeati447 – 480TPR 5Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi552 – 561Poly-Lys10
Compositional biasi662 – 665Poly-Lys4

Domaini

The C-terminus is essential for the interaction with the SRP68/7S RNA complex.By similarity

Sequence similaritiesi

Belongs to the SRP72 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2376. Eukaryota.
ENOG410XRWI. LUCA.
GeneTreeiENSGT00390000013264.
HOGENOMiHOG000006745.
HOVERGENiHBG059920.
InParanoidiO76094.
KOiK03108.
OMAiLWKQNPK.
OrthoDBiEOG091G04IK.
PhylomeDBiO76094.
TreeFamiTF106250.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiView protein in InterPro
IPR013699. Signal_recog_part_SRP72_RNA-bd.
IPR026270. SRP72.
IPR031545. SRP_TPR-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
PANTHERiPTHR14094. PTHR14094. 1 hit.
PfamiView protein in Pfam
PF08492. SRP72. 1 hit.
PF17004. SRP_TPR_like. 1 hit.
PF13181. TPR_8. 2 hits.
PIRSFiPIRSF038922. SRP72. 1 hit.
SMARTiView protein in SMART
SM00028. TPR. 5 hits.
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiView protein in PROSITE
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76094-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC
60 70 80 90 100
KVVCLIQNGS FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT
110 120 130 140 150
IESANQQTDK LKELYGQVLY RLERYDECLA VYRDLVRNSQ DDYDEERKTN
160 170 180 190 200
LSAVVAAQSN WEKVVPENLG LQEGTHELCY NTACALIGQG QLNQAMKILQ
210 220 230 240 250
KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG RTEEALQLYN
260 270 280 290 300
QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK
310 320 330 340 350
KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR
360 370 380 390 400
EKQHTKAIEL LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE
410 420 430 440 450
ELKHKPGMVS ALVTMYSHEE DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI
460 470 480 490 500
REAANFKLKY GRKKEAISDL QQLWKQNPKD IHTLAQLISA YSLVDPEKAK
510 520 530 540 550
ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD SQPKEQGQGD
560 570 580 590 600
LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK
610 620 630 640 650
GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA
660 670
GAPATKKKQQ QKKKKGGKGG W
Length:671
Mass (Da):74,606
Last modified:January 23, 2007 - v3
Checksum:iCC0BA17AC52E3613
GO
Isoform 2 (identifier: O76094-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-275: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):67,879
Checksum:i6351C7451A38ECEC
GO

Sequence cautioni

O76094: The sequence CAD97950 differs from that shown. Reason: Frameshift at position 565.Curated
O76094: The sequence CAD97950 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Q → R in CAD97950 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068522207R → H in BMFS1; affects protein localization to ER. 1 PublicationCorresponds to variant dbSNP:rs387907189Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045576215 – 275Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077019 mRNA. Translation: AAC27324.1.
AF069765 mRNA. Translation: AAC97490.1.
BX537991 mRNA. Translation: CAD97950.1. Sequence problems.
AC114766 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05498.1.
CCDSiCCDS3506.1. [O76094-1]
CCDS58898.1. [O76094-2]
RefSeqiNP_001254651.1. NM_001267722.1. [O76094-2]
NP_008878.3. NM_006947.3. [O76094-1]
UniGeneiHs.237825.

Genome annotation databases

EnsembliENST00000342756; ENSP00000342181; ENSG00000174780. [O76094-1]
ENST00000510663; ENSP00000424576; ENSG00000174780. [O76094-2]
GeneIDi6731.
KEGGihsa:6731.
UCSCiuc010ihe.4. human. [O76094-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRP72_HUMAN
AccessioniPrimary (citable) accession number: O76094
Secondary accession number(s): G5E9Z8, Q7Z3C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families