ID   FGF18_HUMAN             Reviewed;         207 AA.
AC   O76093; D3DQL7; Q6UWF1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-JAN-2012, entry version 101.
DE   RecName: Full=Fibroblast growth factor 18;
DE            Short=FGF-18;
DE   AltName: Full=zFGF5;
DE   Flags: Precursor;
GN   Name=FGF18; ORFNames=UNQ420/PRO856;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=98414622; PubMed=9742123;
RA   Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S.,
RA   Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T.,
RA   Danilenko D.M.;
RT   "FGF-18, a novel member of the fibroblast growth factor family,
RT   stimulates hepatic and intestinal proliferation.";
RL   Mol. Cell. Biol. 18:6063-6074(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RX   MEDLINE=98325019; PubMed=9660775; DOI=10.1074/jbc.273.29.18161;
RA   Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.;
RT   "Structure and expression of the mRNA encoding a novel fibroblast
RT   growth factor, FGF-18.";
RL   J. Biol. Chem. 273:18161-18164(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S.,
RA   Hansen B., Sheppard P., O'Hara P.;
RT   "Homo sapiens homologue of fibroblast growth factor.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [8]
RP   INTERACTION WITH FGFR3 AND FGFR4, AND FUNCTION IN STIMULATION OF CELL
RP   PROLIFERATION.
RX   PubMed=16597617; DOI=10.1074/jbc.M601252200;
RA   Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M.,
RA   Ornitz D.M.;
RT   "Receptor specificity of the fibroblast growth factor family. The
RT   complete mammalian FGF family.";
RL   J. Biol. Chem. 281:15694-15700(2006).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND DISULFIDE BOND.
RA   Vilbois F.;
RL   Submitted (MAR-2010) to UniProtKB.
RN   [10]
RP   REVIEW.
RX   PubMed=20094046; DOI=10.1038/nrc2780;
RA   Turner N., Grose R.;
RT   "Fibroblast growth factor signalling: from development to cancer.";
RL   Nat. Rev. Cancer 10:116-129(2010).
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation, cell differentiation and cell migration. Required
CC       for normal ossification and bone development. Stimulates hepatic
CC       and intestinal proliferation.
CC   -!- SUBUNIT: Interacts with FGFR3 and FGFR4.
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; AF075292; AAC62240.1; -; mRNA.
DR   EMBL; AB007422; BAA31986.1; -; mRNA.
DR   EMBL; AF211188; AAF22977.1; -; mRNA.
DR   EMBL; BT019570; AAV38377.1; -; mRNA.
DR   EMBL; BT019571; AAV38378.1; -; mRNA.
DR   EMBL; CH471062; EAW61441.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61442.1; -; Genomic_DNA.
DR   EMBL; BC006245; AAH06245.1; -; mRNA.
DR   EMBL; AY358811; AAQ89954.1; -; mRNA.
DR   IPI; IPI00008830; -.
DR   RefSeq; NP_003853.1; NM_003862.2.
DR   UniGene; Hs.87191; -.
DR   ProteinModelPortal; O76093; -.
DR   SMR; O76093; 33-180.
DR   IntAct; O76093; 1.
DR   STRING; O76093; -.
DR   PRIDE; O76093; -.
DR   Ensembl; ENST00000274625; ENSP00000274625; ENSG00000156427.
DR   GeneID; 8817; -.
DR   KEGG; hsa:8817; -.
DR   UCSC; uc003mbk.1; human.
DR   CTD; 8817; -.
DR   GeneCards; GC05P170846; -.
DR   H-InvDB; HIX0200755; -.
DR   HGNC; HGNC:3674; FGF18.
DR   HPA; HPA018795; -.
DR   MIM; 603726; gene.
DR   neXtProt; NX_O76093; -.
DR   PharmGKB; PA28113; -.
DR   eggNOG; prNOG12955; -.
DR   GeneTree; ENSGT00570000079132; -.
DR   HOGENOM; HBG714373; -.
DR   HOVERGEN; HBG005659; -.
DR   InParanoid; O76093; -.
DR   OMA; RIRGKET; -.
DR   OrthoDB; EOG4NGGNQ; -.
DR   PhylomeDB; O76093; -.
DR   Pathway_Interaction_DB; fgf_pathway; FGF signaling pathway.
DR   Reactome; REACT_111102; Signal Transduction.
DR   NextBio; 33074; -.
DR   ArrayExpress; O76093; -.
DR   Bgee; O76093; -.
DR   CleanEx; HS_FGF18; -.
DR   Genevestigator; O76093; -.
DR   GermOnline; ENSG00000156427; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0005730; C:nucleolus; IDA:LIFEdb.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome.
DR   GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IDA:UniProtKB.
DR   GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IDA:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Growth factor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL        1     27       Potential.
FT   CHAIN        28    207       Fibroblast growth factor 18.
FT                                /FTId=PRO_0000008990.
FT   CARBOHYD     39     39       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    137    137       N-linked (GlcNAc...) (Potential).
FT   DISULFID    109    127
SQ   SEQUENCE   207 AA;  23989 MW;  57F69E7B30181500 CRC64;
     MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
     TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
     DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
     GQPELQKPFK YTTVTKRSRR IRPTHPA
//