ID FGF18_HUMAN Reviewed; 207 AA. AC O76093; Q6UWF1; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 03-NOV-2009, entry version 81. DE RecName: Full=Fibroblast growth factor 18; DE Short=FGF-18; DE AltName: Full=zFGF5; DE Flags: Precursor; GN Name=FGF18; ORFNames=UNQ420/PRO856; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98414622; PubMed=9742123; RA Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., RA Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., RA Danilenko D.M.; RT "FGF-18, a novel member of the fibroblast growth factor family, RT stimulates hepatic and intestinal proliferation."; RL Mol. Cell. Biol. 18:6063-6074(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung; RX MEDLINE=98325019; PubMed=9660775; DOI=10.1074/jbc.273.29.18161; RA Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.; RT "Structure and expression of the mRNA encoding a novel fibroblast RT growth factor, FGF-18."; RL J. Biol. Chem. 273:18161-18164(1998). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., RA Hansen B., Sheppard P., O'Hara P.; RT "Homo sapiens homologue of fibroblast growth factor."; RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). CC -!- FUNCTION: Stimulates hepatic and intestinal proliferation. CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF075292; AAC62240.1; -; mRNA. DR EMBL; AB007422; BAA31986.1; -; mRNA. DR EMBL; AF211188; AAF22977.1; -; mRNA. DR EMBL; BT019570; AAV38377.1; -; mRNA. DR EMBL; BT019571; AAV38378.1; -; mRNA. DR EMBL; BC006245; AAH06245.1; -; mRNA. DR EMBL; AY358811; AAQ89954.1; -; mRNA. DR IPI; IPI00008830; -. DR RefSeq; NP_003853.1; -. DR UniGene; Hs.87191; -. DR HSSP; P31371; 1G82. DR STRING; O76093; -. DR PRIDE; O76093; -. DR Ensembl; ENST00000274625; ENSP00000274625; ENSG00000156427; Homo sapiens. DR GeneID; 8817; -. DR KEGG; hsa:8817; -. DR UCSC; uc003mbk.1; human. DR CTD; 8817; -. DR GeneCards; GC05P170779; -. DR H-InvDB; HIX0005412; -. DR HGNC; HGNC:3674; FGF18. DR HPA; HPA018795; -. DR MIM; 603726; gene. DR PharmGKB; PA28113; -. DR HOGENOM; O76093; -. DR HOVERGEN; O76093; -. DR OMA; EDGDKYX; -. DR Pathway_Interaction_DB; fgf_pathway; FGF signaling pathway. DR Reactome; REACT_9470; Signaling by FGFR. DR NextBio; 33074; -. DR ArrayExpress; O76093; -. DR Bgee; O76093; -. DR CleanEx; HS_FGF18; -. DR Genevestigator; O76093; -. DR GermOnline; ENSG00000156427; Homo sapiens. DR GO; GO:0005615; C:extracellular space; TAS:ProtInc. DR GO; GO:0005730; C:nucleolus; IDA:LIFEdb. DR GO; GO:0008083; F:growth factor activity; TAS:ProtInc. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00262; IL1HBGF. DR ProDom; PD000831; IL1_HBGF; 1. DR SMART; SM00442; FGF; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 2: Evidence at transcript level; KW Complete proteome; Glycoprotein; Growth factor; Secreted; Signal. FT SIGNAL 1 27 Potential. FT CHAIN 28 207 Fibroblast growth factor 18. FT /FTId=PRO_0000008990. FT CARBOHYD 39 39 N-linked (GlcNAc...) (Potential). FT CARBOHYD 137 137 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 207 AA; 23989 MW; 57F69E7B30181500 CRC64; MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR IRPTHPA //