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O76093

- FGF18_HUMAN

UniProt

O76093 - FGF18_HUMAN

Protein

Fibroblast growth factor 18

Gene

FGF18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.1 Publication

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc
    2. type 1 fibroblast growth factor receptor binding Source: UniProtKB
    3. type 2 fibroblast growth factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. angiogenesis Source: Ensembl
    3. cell-cell signaling Source: ProtInc
    4. chondrocyte development Source: Ensembl
    5. endochondral ossification Source: Ensembl
    6. epidermal growth factor receptor signaling pathway Source: Reactome
    7. Fc-epsilon receptor signaling pathway Source: Reactome
    8. fibroblast growth factor receptor signaling pathway Source: Reactome
    9. innate immune response Source: Reactome
    10. insulin receptor signaling pathway Source: Reactome
    11. intramembranous ossification Source: Ensembl
    12. lung development Source: Ensembl
    13. nervous system development Source: Ensembl
    14. neurotrophin TRK receptor signaling pathway Source: Reactome
    15. phosphatidylinositol-mediated signaling Source: Reactome
    16. positive regulation of cell proliferation Source: ProtInc
    17. positive regulation of chondrocyte differentiation Source: Ensembl
    18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    19. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
    20. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiO76093.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 18
    Short name:
    FGF-18
    Alternative name(s):
    zFGF5
    Gene namesi
    Name:FGF18
    ORF Names:UNQ420/PRO856
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:3674. FGF18.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc
    3. nucleolus Source: LIFEdb

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 207180Fibroblast growth factor 18PRO_0000008990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 1271 Publication
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76093.
    PRIDEiO76093.

    PTM databases

    PhosphoSiteiO76093.

    Expressioni

    Gene expression databases

    BgeeiO76093.
    CleanExiHS_FGF18.
    GenevestigatoriO76093.

    Organism-specific databases

    HPAiHPA018795.

    Interactioni

    Subunit structurei

    Interacts with FGFR3 and FGFR4.1 Publication

    Protein-protein interaction databases

    BioGridi114344. 1 interaction.
    IntActiO76093. 1 interaction.
    STRINGi9606.ENSP00000274625.

    Structurei

    Secondary structure

    1
    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi52 – 598
    Turni60 – 623
    Beta strandi63 – 686
    Beta strandi73 – 775
    Helixi82 – 843
    Beta strandi86 – 905
    Beta strandi94 – 1018
    Turni102 – 1043
    Beta strandi107 – 1104
    Beta strandi116 – 1205
    Helixi125 – 1273
    Beta strandi129 – 1335
    Beta strandi139 – 1468
    Helixi162 – 1643
    Helixi170 – 1723
    Beta strandi174 – 1774

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CJMX-ray2.70A/B/C/D50-190[»]
    ProteinModelPortaliO76093.
    SMRiO76093. Positions 33-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269838.
    HOGENOMiHOG000115986.
    HOVERGENiHBG005659.
    InParanoidiO76093.
    KOiK04358.
    OMAiLMANITI.
    OrthoDBiEOG7DFXD5.
    PhylomeDBiO76093.
    TreeFamiTF331233.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028289. FGF18.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF4. PTHR11486:SF4. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O76093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK    50
    QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK 100
    GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY 150
    VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR 200
    IRPTHPA 207
    Length:207
    Mass (Da):23,989
    Last modified:November 1, 1998 - v1
    Checksum:i57F69E7B30181500
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075292 mRNA. Translation: AAC62240.1.
    AB007422 mRNA. Translation: BAA31986.1.
    AF211188 mRNA. Translation: AAF22977.1.
    BT019570 mRNA. Translation: AAV38377.1.
    BT019571 mRNA. Translation: AAV38378.1.
    CH471062 Genomic DNA. Translation: EAW61441.1.
    CH471062 Genomic DNA. Translation: EAW61442.1.
    BC006245 mRNA. Translation: AAH06245.1.
    AY358811 mRNA. Translation: AAQ89954.1.
    CCDSiCCDS4378.1.
    RefSeqiNP_003853.1. NM_003862.2.
    UniGeneiHs.87191.

    Genome annotation databases

    EnsembliENST00000274625; ENSP00000274625; ENSG00000156427.
    GeneIDi8817.
    KEGGihsa:8817.
    UCSCiuc003mbk.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075292 mRNA. Translation: AAC62240.1 .
    AB007422 mRNA. Translation: BAA31986.1 .
    AF211188 mRNA. Translation: AAF22977.1 .
    BT019570 mRNA. Translation: AAV38377.1 .
    BT019571 mRNA. Translation: AAV38378.1 .
    CH471062 Genomic DNA. Translation: EAW61441.1 .
    CH471062 Genomic DNA. Translation: EAW61442.1 .
    BC006245 mRNA. Translation: AAH06245.1 .
    AY358811 mRNA. Translation: AAQ89954.1 .
    CCDSi CCDS4378.1.
    RefSeqi NP_003853.1. NM_003862.2.
    UniGenei Hs.87191.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CJM X-ray 2.70 A/B/C/D 50-190 [» ]
    ProteinModelPortali O76093.
    SMRi O76093. Positions 33-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114344. 1 interaction.
    IntActi O76093. 1 interaction.
    STRINGi 9606.ENSP00000274625.

    PTM databases

    PhosphoSitei O76093.

    Proteomic databases

    PaxDbi O76093.
    PRIDEi O76093.

    Protocols and materials databases

    DNASUi 8817.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274625 ; ENSP00000274625 ; ENSG00000156427 .
    GeneIDi 8817.
    KEGGi hsa:8817.
    UCSCi uc003mbk.3. human.

    Organism-specific databases

    CTDi 8817.
    GeneCardsi GC05P170846.
    HGNCi HGNC:3674. FGF18.
    HPAi HPA018795.
    MIMi 603726. gene.
    neXtProti NX_O76093.
    PharmGKBi PA28113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269838.
    HOGENOMi HOG000115986.
    HOVERGENi HBG005659.
    InParanoidi O76093.
    KOi K04358.
    OMAi LMANITI.
    OrthoDBi EOG7DFXD5.
    PhylomeDBi O76093.
    TreeFami TF331233.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki O76093.

    Miscellaneous databases

    ChiTaRSi FGF18. human.
    GeneWikii FGF18.
    GenomeRNAii 8817.
    NextBioi 33074.
    PROi O76093.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76093.
    CleanExi HS_FGF18.
    Genevestigatori O76093.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028289. FGF18.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF4. PTHR11486:SF4. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
      Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
      Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
      Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
      J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "Homo sapiens homologue of fibroblast growth factor."
      Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
    8. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    9. Vilbois F.
      Submitted (MAR-2010) to UniProtKB
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BOND.
    10. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF18_HUMAN
    AccessioniPrimary (citable) accession number: O76093
    Secondary accession number(s): D3DQL7, Q6UWF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3