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O76093

- FGF18_HUMAN

UniProt

O76093 - FGF18_HUMAN

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Protein

Fibroblast growth factor 18

Gene
FGF18, UNQ420/PRO856
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.1 Publication

GO - Molecular functioni

  1. growth factor activity Source: ProtInc
  2. type 1 fibroblast growth factor receptor binding Source: UniProtKB
  3. type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. angiogenesis Source: Ensembl
  3. cell-cell signaling Source: ProtInc
  4. chondrocyte development Source: Ensembl
  5. endochondral ossification Source: Ensembl
  6. epidermal growth factor receptor signaling pathway Source: Reactome
  7. Fc-epsilon receptor signaling pathway Source: Reactome
  8. fibroblast growth factor receptor signaling pathway Source: Reactome
  9. innate immune response Source: Reactome
  10. insulin receptor signaling pathway Source: Reactome
  11. intramembranous ossification Source: Ensembl
  12. lung development Source: Ensembl
  13. nervous system development Source: Ensembl
  14. neurotrophin TRK receptor signaling pathway Source: Reactome
  15. phosphatidylinositol-mediated signaling Source: Reactome
  16. positive regulation of cell proliferation Source: ProtInc
  17. positive regulation of chondrocyte differentiation Source: Ensembl
  18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  19. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  20. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiO76093.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Alternative name(s):
zFGF5
Gene namesi
Name:FGF18
ORF Names:UNQ420/PRO856
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3674. FGF18.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: ProtInc
  3. nucleolus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 207180Fibroblast growth factor 18PRO_0000008990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 1271 Publication
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76093.
PRIDEiO76093.

PTM databases

PhosphoSiteiO76093.

Expressioni

Gene expression databases

BgeeiO76093.
CleanExiHS_FGF18.
GenevestigatoriO76093.

Organism-specific databases

HPAiHPA018795.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.1 Publication

Protein-protein interaction databases

BioGridi114344. 1 interaction.
IntActiO76093. 1 interaction.
STRINGi9606.ENSP00000274625.

Structurei

Secondary structure

1
207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi52 – 598
Turni60 – 623
Beta strandi63 – 686
Beta strandi73 – 775
Helixi82 – 843
Beta strandi86 – 905
Beta strandi94 – 1018
Turni102 – 1043
Beta strandi107 – 1104
Beta strandi116 – 1205
Helixi125 – 1273
Beta strandi129 – 1335
Beta strandi139 – 1468
Helixi162 – 1643
Helixi170 – 1723
Beta strandi174 – 1774

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CJMX-ray2.70A/B/C/D50-190[»]
ProteinModelPortaliO76093.
SMRiO76093. Positions 33-180.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269838.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiO76093.
KOiK04358.
OMAiLMANITI.
OrthoDBiEOG7DFXD5.
PhylomeDBiO76093.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76093-1 [UniParc]FASTAAdd to Basket

« Hide

MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK    50
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK 100
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY 150
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR 200
IRPTHPA 207
Length:207
Mass (Da):23,989
Last modified:November 1, 1998 - v1
Checksum:i57F69E7B30181500
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075292 mRNA. Translation: AAC62240.1.
AB007422 mRNA. Translation: BAA31986.1.
AF211188 mRNA. Translation: AAF22977.1.
BT019570 mRNA. Translation: AAV38377.1.
BT019571 mRNA. Translation: AAV38378.1.
CH471062 Genomic DNA. Translation: EAW61441.1.
CH471062 Genomic DNA. Translation: EAW61442.1.
BC006245 mRNA. Translation: AAH06245.1.
AY358811 mRNA. Translation: AAQ89954.1.
CCDSiCCDS4378.1.
RefSeqiNP_003853.1. NM_003862.2.
UniGeneiHs.87191.

Genome annotation databases

EnsembliENST00000274625; ENSP00000274625; ENSG00000156427.
GeneIDi8817.
KEGGihsa:8817.
UCSCiuc003mbk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075292 mRNA. Translation: AAC62240.1 .
AB007422 mRNA. Translation: BAA31986.1 .
AF211188 mRNA. Translation: AAF22977.1 .
BT019570 mRNA. Translation: AAV38377.1 .
BT019571 mRNA. Translation: AAV38378.1 .
CH471062 Genomic DNA. Translation: EAW61441.1 .
CH471062 Genomic DNA. Translation: EAW61442.1 .
BC006245 mRNA. Translation: AAH06245.1 .
AY358811 mRNA. Translation: AAQ89954.1 .
CCDSi CCDS4378.1.
RefSeqi NP_003853.1. NM_003862.2.
UniGenei Hs.87191.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CJM X-ray 2.70 A/B/C/D 50-190 [» ]
ProteinModelPortali O76093.
SMRi O76093. Positions 33-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114344. 1 interaction.
IntActi O76093. 1 interaction.
STRINGi 9606.ENSP00000274625.

PTM databases

PhosphoSitei O76093.

Proteomic databases

PaxDbi O76093.
PRIDEi O76093.

Protocols and materials databases

DNASUi 8817.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274625 ; ENSP00000274625 ; ENSG00000156427 .
GeneIDi 8817.
KEGGi hsa:8817.
UCSCi uc003mbk.3. human.

Organism-specific databases

CTDi 8817.
GeneCardsi GC05P170846.
HGNCi HGNC:3674. FGF18.
HPAi HPA018795.
MIMi 603726. gene.
neXtProti NX_O76093.
PharmGKBi PA28113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269838.
HOGENOMi HOG000115986.
HOVERGENi HBG005659.
InParanoidi O76093.
KOi K04358.
OMAi LMANITI.
OrthoDBi EOG7DFXD5.
PhylomeDBi O76093.
TreeFami TF331233.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinki O76093.

Miscellaneous databases

ChiTaRSi FGF18. human.
GeneWikii FGF18.
GenomeRNAii 8817.
NextBioi 33074.
PROi O76093.
SOURCEi Search...

Gene expression databases

Bgeei O76093.
CleanExi HS_FGF18.
Genevestigatori O76093.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
    Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
    Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
    Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
    J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "Homo sapiens homologue of fibroblast growth factor."
    Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
  8. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  9. Vilbois F.
    Submitted (MAR-2010) to UniProtKB
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BOND.
  10. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF18_HUMAN
AccessioniPrimary (citable) accession number: O76093
Secondary accession number(s): D3DQL7, Q6UWF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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