Reviewed, UniProtKB/Swiss-Prot O76093 (FGF18_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 18
      Short name=FGF-18
Alternative name(s):
    zFGF5

Gene names

Name:	FGF18
ORF Names:	UNQ420/PRO856

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Stimulates hepatic and intestinal proliferation.
Subcellular location	SecretedBy similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome positive regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.1 Traceable author statement. Source: ProtInc nucleolus Inferred from direct assay. Source: LIFEdb
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 207	180	Fibroblast growth factor 18		PRO_0000008990
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O76093-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 57F69E7B30181500	FASTA	207	23,989
	10 20 30 40 50 60 MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 70 80 90 100 110 120 TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 130 140 150 160 170 180 DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 190 200 GQPELQKPFK YTTVTKRSRR IRPTHPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation." Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M. Mol. Cell. Biol. 18:6063-6074(1998) [PubMed: 9742123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18." Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N. J. Biol. Chem. 273:18161-18164(1998) [PubMed: 9660775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"Homo sapiens homologue of fibroblast growth factor." Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF075292 mRNA. Translation: AAC62240.1. AB007422 mRNA. Translation: BAA31986.1. AF211188 mRNA. Translation: AAF22977.1. BT019570 mRNA. Translation: AAV38377.1. BT019571 mRNA. Translation: AAV38378.1. BC006245 mRNA. Translation: AAH06245.1. AY358811 mRNA. Translation: AAQ89954.1.
RefSeq	NP_003853.1.
UniGene	Hs.87191
3D structure databases
HSSP	HSSP built from PDB template 1G82 based on UniProtKB P31371.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000156427. Homo sapiens. [Contig view]
GeneID	8817.
KEGG	hsa:8817.
Organism-specific databases
H-InvDB	HIX0005412.
HGNC	HGNC:3674. FGF18.
HPA	HPA018795.
MIM	603726. gene.
PharmGKB	PA28113.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O76093.
HOVERGEN	O76093.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
ArrayExpress	O76093.
CleanEx	HS_FGF18.
GermOnline	ENSG00000156427. Homo sapiens.
Family and domain databases
InterPro	IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33074.
SOURCE	Search...

Entry information

Entry name

FGF18_HUMAN

Accession

Primary (citable) accession number: O76093
Secondary accession number(s): Q6UWF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	November 25, 2008
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)