O76093 (FGF18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 18
Short name=FGF-18

Alternative name(s):
zFGF5

Gene names

Name:	FGF18
ORF Names:	UNQ420/PRO856

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Ref.8
Subunit structure	Interacts with FGFR3 and FGFR4. Ref.8
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc angiogenesis Inferred from electronic annotation. Source: Compara cell-cell signaling Traceable author statement Ref.1. Source: ProtInc chondrocyte development Inferred from electronic annotation. Source: Compara endochondral ossification Inferred from electronic annotation. Source: Compara fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome intramembranous ossification Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara nervous system development Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc positive regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Traceable author statement Ref.1. Source: ProtInc nucleolus Inferred from direct assay. Source: LIFEdb
Molecular_function	growth factor activity Traceable author statement Ref.1. Source: ProtInc type 1 fibroblast growth factor receptor binding Inferred from direct assay PubMed 16384934. Source: UniProtKB type 2 fibroblast growth factor receptor binding Inferred from direct assay PubMed 16384934. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 207	180	Fibroblast growth factor 18		PRO_0000008990
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Disulfide bond	109 ↔ 127		Ref.9

Sequences

	Sequence		Length	Mass (Da)
	O76093 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 57F69E7B30181500	FASTA	207	23,989
	10 20 30 40 50 60 MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 70 80 90 100 110 120 TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 130 140 150 160 170 180 DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 190 200 GQPELQKPFK YTTVTKRSRR IRPTHPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation." Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M. Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18." Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N. J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"Homo sapiens homologue of fibroblast growth factor." Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
[8]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[9]	Vilbois F. Submitted (MAR-2010) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BOND.
[10]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF075292 mRNA. Translation: AAC62240.1. AB007422 mRNA. Translation: BAA31986.1. AF211188 mRNA. Translation: AAF22977.1. BT019570 mRNA. Translation: AAV38377.1. BT019571 mRNA. Translation: AAV38378.1. CH471062 Genomic DNA. Translation: EAW61441.1. CH471062 Genomic DNA. Translation: EAW61442.1. BC006245 mRNA. Translation: AAH06245.1. AY358811 mRNA. Translation: AAQ89954.1.
IPI	IPI00008830.
RefSeq	NP_003853.1. NM_003862.2.
UniGene	Hs.87191.
3D structure databases
ProteinModelPortal	O76093.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76093. 1 interaction.
STRING	9606.ENSP00000274625.
PTM databases
PhosphoSite	O76093.
Proteomic databases
PaxDb	O76093.
PRIDE	O76093.
Protocols and materials databases
DNASU	8817.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274625; ENSP00000274625; ENSG00000156427.
GeneID	8817.
KEGG	hsa:8817.
UCSC	uc003mbk.3. human.
Organism-specific databases
CTD	8817.
GeneCards	GC05P170846.
HGNC	HGNC:3674. FGF18.
HPA	HPA018795.
MIM	603726. gene.
neXtProt	NX_O76093.
PharmGKB	PA28113.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG269838.
HOGENOM	HOG000115986.
HOVERGEN	HBG005659.
InParanoid	O76093.
KO	K04358.
OMA	RGKETNF.
OrthoDB	EOG4NGGNQ.
PhylomeDB	O76093.
Enzyme and pathway databases
Pathway_Interaction_DB	fgf_pathway. FGF signaling pathway.
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
Bgee	O76093.
CleanEx	HS_FGF18.
Genevestigator	O76093.
GermOnline	ENSG00000156427. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FGF18. human.
GenomeRNAi	8817.
NextBio	33074.
SOURCE	Search...

Entry information

Entry name

FGF18_HUMAN

Accession

Primary (citable) accession number: O76093
Secondary accession number(s): D3DQL7, Q6UWF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.