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Protein

Fibroblast growth factor 18

Gene

FGF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • angiogenesis Source: Ensembl
  • cell-cell signaling Source: ProtInc
  • chondrocyte development Source: Ensembl
  • endochondral ossification Source: Ensembl
  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • intramembranous ossification Source: Ensembl
  • lung development Source: Ensembl
  • MAPK cascade Source: Reactome
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of chondrocyte differentiation Source: Ensembl
  • positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: Reactome
  • positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190371 FGFR3b ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiO76093
SIGNORiO76093

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Alternative name(s):
zFGF5
Gene namesi
Name:FGF18
ORF Names:UNQ420/PRO856
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000156427.7
HGNCiHGNC:3674 FGF18
MIMi603726 gene
neXtProtiNX_O76093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8817
OpenTargetsiENSG00000156427
PharmGKBiPA28113

Polymorphism and mutation databases

BioMutaiFGF18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000899028 – 207Fibroblast growth factor 18Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 1271 Publication
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO76093
PaxDbiO76093
PeptideAtlasiO76093
PRIDEiO76093

PTM databases

iPTMnetiO76093
PhosphoSitePlusiO76093

Expressioni

Gene expression databases

BgeeiENSG00000156427
CleanExiHS_FGF18
GenevisibleiO76093 HS

Organism-specific databases

HPAiHPA018795

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.1 Publication

GO - Molecular functioni

  • growth factor activity Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • type 1 fibroblast growth factor receptor binding Source: UniProtKB
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114344, 1 interactor
IntActiO76093, 1 interactor
STRINGi9606.ENSP00000274625

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 59Combined sources8
Turni60 – 62Combined sources3
Beta strandi63 – 68Combined sources6
Beta strandi73 – 77Combined sources5
Helixi82 – 84Combined sources3
Beta strandi86 – 90Combined sources5
Beta strandi94 – 101Combined sources8
Turni102 – 104Combined sources3
Beta strandi107 – 110Combined sources4
Beta strandi116 – 120Combined sources5
Helixi125 – 127Combined sources3
Beta strandi129 – 133Combined sources5
Beta strandi139 – 146Combined sources8
Helixi162 – 164Combined sources3
Helixi170 – 172Combined sources3
Beta strandi174 – 177Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CJMX-ray2.70A/B/C/D50-190[»]
ProteinModelPortaliO76093
SMRiO76093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOGENOMiHOG000115986
HOVERGENiHBG005659
InParanoidiO76093
KOiK04358
OMAiMFVAEEN
OrthoDBiEOG091G0NQH
PhylomeDBiO76093
TreeFamiTF331233

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028289 FGF18
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF124 PTHR11486:SF124, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK
60 70 80 90 100
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
110 120 130 140 150
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
160 170 180 190 200
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR

IRPTHPA
Length:207
Mass (Da):23,989
Last modified:November 1, 1998 - v1
Checksum:i57F69E7B30181500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075292 mRNA Translation: AAC62240.1
AB007422 mRNA Translation: BAA31986.1
AF211188 mRNA Translation: AAF22977.1
BT019570 mRNA Translation: AAV38377.1
BT019571 mRNA Translation: AAV38378.1
CH471062 Genomic DNA Translation: EAW61441.1
CH471062 Genomic DNA Translation: EAW61442.1
BC006245 mRNA Translation: AAH06245.1
AY358811 mRNA Translation: AAQ89954.1
CCDSiCCDS4378.1
RefSeqiNP_003853.1, NM_003862.2
UniGeneiHs.87191

Genome annotation databases

EnsembliENST00000274625; ENSP00000274625; ENSG00000156427
GeneIDi8817
KEGGihsa:8817
UCSCiuc003mbk.4 human

Similar proteinsi

Entry informationi

Entry nameiFGF18_HUMAN
AccessioniPrimary (citable) accession number: O76093
Secondary accession number(s): D3DQL7, Q6UWF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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