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O76093 (FGF18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 18

Short name=FGF-18
Alternative name(s):
zFGF5
Gene names
Name:FGF18
ORF Names:UNQ420/PRO856
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Ref.8

Subunit structure

Interacts with FGFR3 and FGFR4. Ref.8

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

anatomical structure morphogenesis

Traceable author statement Ref.1. Source: ProtInc

angiogenesis

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

chondrocyte development

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

intramembranous ossification

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from electronic annotation. Source: Ensembl

nervous system development

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Traceable author statement Ref.1. Source: ProtInc

positive regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Traceable author statement Ref.1. Source: ProtInc

nucleolus

Inferred from direct assay. Source: LIFEdb

   Molecular_functiongrowth factor activity

Traceable author statement Ref.1. Source: ProtInc

type 1 fibroblast growth factor receptor binding

Inferred from direct assay PubMed 16384934. Source: UniProtKB

type 2 fibroblast growth factor receptor binding

Inferred from direct assay PubMed 16384934. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 207180Fibroblast growth factor 18
PRO_0000008990

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 127 Ref.9

Secondary structure

.............................. 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O76093 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 57F69E7B30181500

FASTA20723,989
        10         20         30         40         50         60 
MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 

        70         80         90        100        110        120 
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 

       130        140        150        160        170        180 
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 

       190        200 
GQPELQKPFK YTTVTKRSRR IRPTHPA 

« Hide

References

« Hide 'large scale' references
[1]"FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"Homo sapiens homologue of fibroblast growth factor."
Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
[8]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[9]Vilbois F.
Submitted (MAR-2010) to UniProtKB
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BOND.
[10]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF075292 mRNA. Translation: AAC62240.1.
AB007422 mRNA. Translation: BAA31986.1.
AF211188 mRNA. Translation: AAF22977.1.
BT019570 mRNA. Translation: AAV38377.1.
BT019571 mRNA. Translation: AAV38378.1.
CH471062 Genomic DNA. Translation: EAW61441.1.
CH471062 Genomic DNA. Translation: EAW61442.1.
BC006245 mRNA. Translation: AAH06245.1.
AY358811 mRNA. Translation: AAQ89954.1.
CCDSCCDS4378.1.
RefSeqNP_003853.1. NM_003862.2.
UniGeneHs.87191.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4CJMX-ray2.70A/B/C/D50-190[»]
ProteinModelPortalO76093.
SMRO76093. Positions 33-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114344. 1 interaction.
IntActO76093. 1 interaction.
STRING9606.ENSP00000274625.

PTM databases

PhosphoSiteO76093.

Proteomic databases

PaxDbO76093.
PRIDEO76093.

Protocols and materials databases

DNASU8817.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274625; ENSP00000274625; ENSG00000156427.
GeneID8817.
KEGGhsa:8817.
UCSCuc003mbk.3. human.

Organism-specific databases

CTD8817.
GeneCardsGC05P170846.
HGNCHGNC:3674. FGF18.
HPAHPA018795.
MIM603726. gene.
neXtProtNX_O76093.
PharmGKBPA28113.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269838.
HOGENOMHOG000115986.
HOVERGENHBG005659.
InParanoidO76093.
KOK04358.
OMALMANITI.
OrthoDBEOG7DFXD5.
PhylomeDBO76093.
TreeFamTF331233.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkO76093.

Gene expression databases

BgeeO76093.
CleanExHS_FGF18.
GenevestigatorO76093.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGF18. human.
GeneWikiFGF18.
GenomeRNAi8817.
NextBio33074.
PROO76093.
SOURCESearch...

Entry information

Entry nameFGF18_HUMAN
AccessionPrimary (citable) accession number: O76093
Secondary accession number(s): D3DQL7, Q6UWF1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM