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Protein

G antigen 7

Gene

GAGE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 7
Short name:
GAGE-7
Alternative name(s):
AL4
Cancer/testis antigen 4.7
Short name:
CT4.7
GAGE-12I
GAGE-7B
GAGE-8
Gene namesi
Name:GAGE7
Synonyms:GAGE12I, GAGE7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000215269.5.
HostDB:ENSG00000236362.7.
HGNCiHGNC:4104. GAGE7.
MIMi300601. gene.
300637. gene.
neXtProtiNX_O76087.

Pathology & Biotechi

Organism-specific databases

DisGeNETi100008586.
2579.
26748.
645073.
PharmGKBiPA145148778.

Polymorphism and mutation databases

BioMutaiGAGE7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483451 – 117G antigen 7Add BLAST117

Proteomic databases

PaxDbiO76087.
PRIDEiO76087.
TopDownProteomicsiO76087.

PTM databases

iPTMnetiO76087.
PhosphoSitePlusiO76087.

Expressioni

Tissue specificityi

Expressed in some prostate cancer tissues but not in normal prostate tissue.

Gene expression databases

BgeeiENSG00000215269.
CleanExiHS_GAGE7.
ExpressionAtlasiO76087. baseline.
GenevisibleiO76087. HS.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

BioGridi117808. 2 interactors.
STRINGi9606.ENSP00000416249.

Structurei

3D structure databases

ProteinModelPortaliO76087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOVERGENiHBG056227.
InParanoidiO76087.
OrthoDBiEOG091G0UGV.
PhylomeDBiO76087.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

O76087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,978
Last modified:November 1, 1998 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058988 mRNA. Translation: AAC25989.1.
AF055474 mRNA. Translation: AAC33677.1.
AF055475 Genomic DNA. Translation: AAC33678.1.
BX649339 Genomic DNA. Translation: CAI95423.1.
BC031628 mRNA. Translation: AAH31628.1.
BC104951 mRNA. Translation: AAI04952.1.
BC121182 mRNA. Translation: AAI21183.1.
BC121183 mRNA. Translation: AAI21184.1.
BC144193 mRNA. Translation: AAI44194.1.
RefSeqiNP_001091875.1. NM_001098405.2.
NP_001091879.1. NM_001098409.1.
NP_001120817.1. NM_001127345.1.
NP_001468.1. NM_001477.1.
NP_066946.1. NM_021123.2.
UniGeneiHs.460641.
Hs.632808.
Hs.632812.
Hs.695912.

Genome annotation databases

GeneIDi100008586.
2579.
26748.
645073.
729428.
KEGGihsa:100008586.
hsa:2579.
hsa:26748.
hsa:645073.
hsa:729428.

Similar proteinsi

Entry informationi

Entry nameiGAGE7_HUMAN
AccessioniPrimary (citable) accession number: O76087
Secondary accession number(s): B7ZM13, Q4V324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome