Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G antigen 7

Gene

GAGE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 7
Short name:
GAGE-7
Alternative name(s):
AL4
Cancer/testis antigen 4.7
Short name:
CT4.7
GAGE-12I
GAGE-7B
GAGE-8
Gene namesi
Name:GAGE7
Synonyms:GAGE12I, GAGE7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:4104. GAGE7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148778.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117G antigen 7PRO_0000148345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO76087.

PTM databases

PhosphoSiteiO76087.

Expressioni

Tissue specificityi

Expressed in some prostate cancer tissues but not in normal prostate tissue.

Gene expression databases

BgeeiO76087.
CleanExiHS_GAGE7.
GenevestigatoriO76087.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

BioGridi117808. 2 interactions.
STRINGi9606.ENSP00000405110.

Structurei

3D structure databases

ProteinModelPortaliO76087.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

HOVERGENiHBG056227.
InParanoidiO76087.
PhylomeDBiO76087.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76087-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,978
Last modified:November 1, 1998 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058988 mRNA. Translation: AAC25989.1.
AF055474 mRNA. Translation: AAC33677.1.
AF055475 Genomic DNA. Translation: AAC33678.1.
BX649339 Genomic DNA. Translation: CAI95423.1.
BC031628 mRNA. Translation: AAH31628.1.
BC104951 mRNA. Translation: AAI04952.1.
BC121182 mRNA. Translation: AAI21183.1.
BC121183 mRNA. Translation: AAI21184.1.
BC144193 mRNA. Translation: AAI44194.1.
RefSeqiNP_001091875.1. NM_001098405.2.
NP_001091879.1. NM_001098409.1.
NP_001468.1. NM_001477.1.
NP_066946.1. NM_021123.2.
UniGeneiHs.460641.
Hs.632808.
Hs.695912.

Genome annotation databases

GeneIDi100008586.
2579.
26748.
645073.
KEGGihsa:100008586.
hsa:2579.
hsa:26748.
hsa:645073.
UCSCiuc004dnw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058988 mRNA. Translation: AAC25989.1.
AF055474 mRNA. Translation: AAC33677.1.
AF055475 Genomic DNA. Translation: AAC33678.1.
BX649339 Genomic DNA. Translation: CAI95423.1.
BC031628 mRNA. Translation: AAH31628.1.
BC104951 mRNA. Translation: AAI04952.1.
BC121182 mRNA. Translation: AAI21183.1.
BC121183 mRNA. Translation: AAI21184.1.
BC144193 mRNA. Translation: AAI44194.1.
RefSeqiNP_001091875.1. NM_001098405.2.
NP_001091879.1. NM_001098409.1.
NP_001468.1. NM_001477.1.
NP_066946.1. NM_021123.2.
UniGeneiHs.460641.
Hs.632808.
Hs.695912.

3D structure databases

ProteinModelPortaliO76087.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117808. 2 interactions.
STRINGi9606.ENSP00000405110.

PTM databases

PhosphoSiteiO76087.

Proteomic databases

PRIDEiO76087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008586.
2579.
26748.
645073.
KEGGihsa:100008586.
hsa:2579.
hsa:26748.
hsa:645073.
UCSCiuc004dnw.4. human.

Organism-specific databases

CTDi100008586.
2579.
26748.
645073.
GeneCardsiGC0XU990070.
HGNCiHGNC:4104. GAGE7.
HPAiHPA043232.
MIMi300601. gene.
300637. gene.
neXtProtiNX_O76087.
PharmGKBiPA145148778.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG056227.
InParanoidiO76087.
PhylomeDBiO76087.

Miscellaneous databases

NextBioi10197.
PROiO76087.
SOURCEiSearch...

Gene expression databases

BgeeiO76087.
CleanExiHS_GAGE7.
GenevestigatoriO76087.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens."
    Chen M.E., Lin S.-H., Chung L.W.K., Sikes R.A.
    J. Biol. Chem. 273:17618-17625(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
    De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
    Cancer Res. 59:3157-3165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGAGE7_HUMAN
AccessioniPrimary (citable) accession number: O76087
Secondary accession number(s): B7ZM13, Q4V324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.