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O76087

- GAGE7_HUMAN

UniProt

O76087 - GAGE7_HUMAN

Protein

G antigen 7

Gene

GAGE7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 7
    Short name:
    GAGE-7
    Alternative name(s):
    AL4
    Cancer/testis antigen 4.7
    Short name:
    CT4.7
    GAGE-12I
    GAGE-7B
    GAGE-8
    Gene namesi
    Name:GAGE7
    Synonyms:GAGE12I, GAGE7B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4104. GAGE7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148778.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117G antigen 7PRO_0000148345Add
    BLAST

    Proteomic databases

    MaxQBiO76087.
    PRIDEiO76087.

    PTM databases

    PhosphoSiteiO76087.

    Expressioni

    Tissue specificityi

    Expressed in some prostate cancer tissues but not in normal prostate tissue.

    Gene expression databases

    BgeeiO76087.
    CleanExiHS_GAGE7.
    GenevestigatoriO76087.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Protein-protein interaction databases

    BioGridi117808. 1 interaction.
    STRINGi9606.ENSP00000405110.

    Structurei

    3D structure databases

    ProteinModelPortaliO76087.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    HOVERGENiHBG056227.
    InParanoidiO76087.
    PhylomeDBiO76087.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76087-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR    50
    QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP 100
    NPEEVKTPEE GEKQSQC 117
    Length:117
    Mass (Da):12,978
    Last modified:November 1, 1998 - v1
    Checksum:i365ED8D41361C7AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058988 mRNA. Translation: AAC25989.1.
    AF055474 mRNA. Translation: AAC33677.1.
    AF055475 Genomic DNA. Translation: AAC33678.1.
    BX649339 Genomic DNA. Translation: CAI95423.1.
    BC031628 mRNA. Translation: AAH31628.1.
    BC104951 mRNA. Translation: AAI04952.1.
    BC121182 mRNA. Translation: AAI21183.1.
    BC121183 mRNA. Translation: AAI21184.1.
    BC144193 mRNA. Translation: AAI44194.1.
    RefSeqiNP_001091875.1. NM_001098405.2.
    NP_001091879.1. NM_001098409.1.
    NP_001468.1. NM_001477.1.
    NP_066946.1. NM_021123.2.
    UniGeneiHs.460641.
    Hs.632808.
    Hs.695912.

    Genome annotation databases

    GeneIDi100008586.
    2579.
    26748.
    645073.
    KEGGihsa:100008586.
    hsa:2579.
    hsa:26748.
    hsa:645073.
    UCSCiuc004dnw.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058988 mRNA. Translation: AAC25989.1 .
    AF055474 mRNA. Translation: AAC33677.1 .
    AF055475 Genomic DNA. Translation: AAC33678.1 .
    BX649339 Genomic DNA. Translation: CAI95423.1 .
    BC031628 mRNA. Translation: AAH31628.1 .
    BC104951 mRNA. Translation: AAI04952.1 .
    BC121182 mRNA. Translation: AAI21183.1 .
    BC121183 mRNA. Translation: AAI21184.1 .
    BC144193 mRNA. Translation: AAI44194.1 .
    RefSeqi NP_001091875.1. NM_001098405.2.
    NP_001091879.1. NM_001098409.1.
    NP_001468.1. NM_001477.1.
    NP_066946.1. NM_021123.2.
    UniGenei Hs.460641.
    Hs.632808.
    Hs.695912.

    3D structure databases

    ProteinModelPortali O76087.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117808. 1 interaction.
    STRINGi 9606.ENSP00000405110.

    PTM databases

    PhosphoSitei O76087.

    Proteomic databases

    MaxQBi O76087.
    PRIDEi O76087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008586.
    2579.
    26748.
    645073.
    KEGGi hsa:100008586.
    hsa:2579.
    hsa:26748.
    hsa:645073.
    UCSCi uc004dnw.4. human.

    Organism-specific databases

    CTDi 100008586.
    2579.
    26748.
    645073.
    GeneCardsi GC0XU990070.
    HGNCi HGNC:4104. GAGE7.
    HPAi HPA043232.
    MIMi 300601. gene.
    300637. gene.
    neXtProti NX_O76087.
    PharmGKBi PA145148778.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG056227.
    InParanoidi O76087.
    PhylomeDBi O76087.

    Miscellaneous databases

    NextBioi 10197.
    PROi O76087.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76087.
    CleanExi HS_GAGE7.
    Genevestigatori O76087.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of PAGE-1 and GAGE-7: new genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens."
      Chen M.E., Lin S.-H., Chung L.W.K., Sikes R.A.
      J. Biol. Chem. 273:17618-17625(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the GAGE genes that are expressed in various human cancers and in normal testis."
      De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S., Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T., van der Bruggen P.
      Cancer Res. 59:3157-3165(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGAGE7_HUMAN
    AccessioniPrimary (citable) accession number: O76087
    Secondary accession number(s): B7ZM13, Q4V324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3