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Protein

AN1-type zinc finger protein 5

Gene

ZFAND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri151 – 194AN1-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 5
Alternative name(s):
Zinc finger A20 domain-containing protein 2
Zinc finger protein 216
Gene namesi
Name:ZFAND5
Synonyms:ZA20D2, ZNF216
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107372.12
HGNCiHGNC:13008 ZFAND5
MIMi604761 gene
neXtProtiNX_O76080

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi7763
OpenTargetsiENSG00000107372
PharmGKBiPA37587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665571 – 213AN1-type zinc finger protein 5Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineCombined sources1
Modified residuei58PhosphoserineBy similarity1
Modified residuei209N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO76080
MaxQBiO76080
PaxDbiO76080
PeptideAtlasiO76080
PRIDEiO76080
TopDownProteomicsiO76080

PTM databases

iPTMnetiO76080
PhosphoSitePlusiO76080

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000107372
CleanExiHS_ZFAND5
ExpressionAtlasiO76080 baseline and differential
GenevisibleiO76080 HS

Organism-specific databases

HPAiHPA018129

Interactioni

Subunit structurei

Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBCP0CG483EBI-8028844,EBI-3390054

Protein-protein interaction databases

BioGridi113546, 14 interactors
IntActiO76080, 6 interactors
MINTiO76080
STRINGi9606.ENSP00000237937

Structurei

3D structure databases

ProteinModelPortaliO76080
SMRiO76080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri151 – 194AN1-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173 Eukaryota
ENOG4111UWC LUCA
GeneTreeiENSGT00510000046525
HOGENOMiHOG000238229
HOVERGENiHBG053349
InParanoidiO76080
OMAiTEGLCSK
OrthoDBiEOG091G0M53
PhylomeDBiO76080
TreeFamiTF313612

Family and domain databases

Gene3Di4.10.1110.10, 1 hit
InterProiView protein in InterPro
IPR035896 AN1-like_Znf
IPR002653 Znf_A20
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF01754 zf-A20, 1 hit
PF01428 zf-AN1, 1 hit
SMARTiView protein in SMART
SM00259 ZnF_A20, 1 hit
SM00154 ZnF_AN1, 1 hit
SUPFAMiSSF118310 SSF118310, 1 hit
PROSITEiView protein in PROSITE
PS51036 ZF_A20, 1 hit
PS51039 ZF_AN1, 1 hit

Sequencei

Sequence statusi: Complete.

O76080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM
60 70 80 90 100
GTASGSNSPT SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ
110 120 130 140 150
MTEMSISRED KITTPKTEVS EPVVTQPSPS VSQPSTSQSE EKAPELPKPK
160 170 180 190 200
KNRCFMCRKK VGLTGFDCRC GNLFCGLHRY SDKHNCPYDY KAEAAAKIRK
210
ENPVVVAEKI QRI
Length:213
Mass (Da):23,132
Last modified:November 1, 1998 - v1
Checksum:iE477504B1BA77753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062072 Genomic DNA Translation: AAC61801.1
AF062346 mRNA Translation: AAC42601.1
AF062347 mRNA Translation: AAC42602.1
AK290849 mRNA Translation: BAF83538.1
AL135924 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62533.1
BC011018 mRNA Translation: AAH11018.1
BC027707 mRNA Translation: AAH27707.1
BC073131 mRNA Translation: AAH73131.1
CCDSiCCDS6642.1
RefSeqiNP_001095890.1, NM_001102420.2
NP_001095891.1, NM_001102421.2
NP_001265172.1, NM_001278243.1
NP_001265173.1, NM_001278244.1
NP_001265174.1, NM_001278245.1
NP_005998.1, NM_006007.3
UniGeneiHs.406096

Genome annotation databases

EnsembliENST00000237937; ENSP00000237937; ENSG00000107372
ENST00000343431; ENSP00000350586; ENSG00000107372
ENST00000376960; ENSP00000366159; ENSG00000107372
ENST00000376962; ENSP00000366161; ENSG00000107372
GeneIDi7763
KEGGihsa:7763
UCSCiuc004aix.3 human

Similar proteinsi

Entry informationi

Entry nameiZFAN5_HUMAN
AccessioniPrimary (citable) accession number: O76080
Secondary accession number(s): A8K484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health