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O76076

- WISP2_HUMAN

UniProt

O76076 - WISP2_HUMAN

Protein

WNT1-inducible-signaling pathway protein 2

Gene

WISP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell-cell signaling Source: ProtInc
    3. regulation of cell growth Source: Ensembl
    4. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    SignaLinkiO76076.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WNT1-inducible-signaling pathway protein 2
    Short name:
    WISP-2
    Alternative name(s):
    CCN family member 5
    Connective tissue growth factor-like protein
    Short name:
    CTGF-L
    Connective tissue growth factor-related protein 58
    Gene namesi
    Name:WISP2
    Synonyms:CCN5, CT58, CTGFL
    ORF Names:UNQ228/PRO261
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:12770. WISP2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37373.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 250227WNT1-inducible-signaling pathway protein 2PRO_0000014409Add
    BLAST

    Proteomic databases

    PaxDbiO76076.
    PeptideAtlasiO76076.
    PRIDEiO76076.

    Expressioni

    Tissue specificityi

    Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.

    Gene expression databases

    ArrayExpressiO76076.
    BgeeiO76076.
    CleanExiHS_WISP2.
    GenevestigatoriO76076.

    Organism-specific databases

    HPAiCAB019273.

    Interactioni

    Protein-protein interaction databases

    BioGridi114366. 2 interactions.
    IntActiO76076. 2 interactions.
    STRINGi9606.ENSP00000190983.

    Structurei

    3D structure databases

    ProteinModelPortaliO76076.
    SMRiO76076. Positions 26-167, 196-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 23845TSP type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82184.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiO76076.
    OMAiSNQNRFC.
    OrthoDBiEOG77T15K.
    PhylomeDBiO76076.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O76076-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGTPKTHLL AFSLLCLLSK VRTQLCPTPC TCPWPPPRCP LGVPLVLDGC    50
    GCCRVCARRL GEPCDQLHVC DASQGLVCQP GAGPGGRGAL CLLAEDDSSC 100
    EVNGRLYREG ETFQPHCSIR CRCEDGGFTC VPLCSEDVRL PSWDCPHPRR 150
    VEVLGKCCPE WVCGQGGGLG TQPLPAQGPQ FSGLVSSLPP GVPCPEWSTA 200
    WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF 250
    Length:250
    Mass (Da):26,825
    Last modified:November 1, 1998 - v1
    Checksum:iC499837EF42FEEAC
    GO
    Isoform 2 (identifier: O76076-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-218: LAEDDSSCEV...GLGMATRVSN → CKQDPSFLAL...AWVHHAEHQY
         219-250: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:218
    Mass (Da):22,577
    Checksum:i2A8A79681111542B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591R → Q.
    Corresponds to variant rs33932543 [ dbSNP | Ensembl ].
    VAR_049566

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei93 – 218126LAEDD…TRVSN → CKQDPSFLALSLPCPLVSPA QNGARPGDPARPPVGWAWPP GCPTRTASADWRPSAACACP GPAHPPGVAVHKTVPSRAGL GMGTRCPPSPAGGPVPGPWA DGRWSVPRPLAAGNTLAWVH HAEHQY in isoform 2. 1 PublicationVSP_056298Add
    BLAST
    Alternative sequencei219 – 25032Missing in isoform 2. 1 PublicationVSP_056299Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083500 mRNA. Translation: AAC70350.1.
    AF074604 mRNA. Translation: AAC26794.1.
    AF100780 mRNA. Translation: AAC96322.1.
    AY358915 mRNA. Translation: AAQ89274.1.
    AK313853 mRNA. Translation: BAG36581.1.
    AL139352 Genomic DNA. Translation: CAB94788.1.
    CH471077 Genomic DNA. Translation: EAW75902.1.
    CH471077 Genomic DNA. Translation: EAW75903.1.
    BC017782 mRNA. Translation: AAH17782.1.
    BC058074 mRNA. Translation: AAH58074.1.
    BC064379 mRNA. Translation: AAH64379.1.
    CCDSiCCDS13336.1.
    RefSeqiNP_003872.1. NM_003881.2.
    XP_005260660.1. XM_005260603.2.
    UniGeneiHs.592145.

    Genome annotation databases

    EnsembliENST00000190983; ENSP00000190983; ENSG00000064205.
    ENST00000372865; ENSP00000361956; ENSG00000064205.
    ENST00000372868; ENSP00000361959; ENSG00000064205.
    GeneIDi8839.
    KEGGihsa:8839.
    UCSCiuc002xmp.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083500 mRNA. Translation: AAC70350.1 .
    AF074604 mRNA. Translation: AAC26794.1 .
    AF100780 mRNA. Translation: AAC96322.1 .
    AY358915 mRNA. Translation: AAQ89274.1 .
    AK313853 mRNA. Translation: BAG36581.1 .
    AL139352 Genomic DNA. Translation: CAB94788.1 .
    CH471077 Genomic DNA. Translation: EAW75902.1 .
    CH471077 Genomic DNA. Translation: EAW75903.1 .
    BC017782 mRNA. Translation: AAH17782.1 .
    BC058074 mRNA. Translation: AAH58074.1 .
    BC064379 mRNA. Translation: AAH64379.1 .
    CCDSi CCDS13336.1.
    RefSeqi NP_003872.1. NM_003881.2.
    XP_005260660.1. XM_005260603.2.
    UniGenei Hs.592145.

    3D structure databases

    ProteinModelPortali O76076.
    SMRi O76076. Positions 26-167, 196-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114366. 2 interactions.
    IntActi O76076. 2 interactions.
    STRINGi 9606.ENSP00000190983.

    Proteomic databases

    PaxDbi O76076.
    PeptideAtlasi O76076.
    PRIDEi O76076.

    Protocols and materials databases

    DNASUi 8839.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000190983 ; ENSP00000190983 ; ENSG00000064205 .
    ENST00000372865 ; ENSP00000361956 ; ENSG00000064205 .
    ENST00000372868 ; ENSP00000361959 ; ENSG00000064205 .
    GeneIDi 8839.
    KEGGi hsa:8839.
    UCSCi uc002xmp.3. human.

    Organism-specific databases

    CTDi 8839.
    GeneCardsi GC20P043343.
    HGNCi HGNC:12770. WISP2.
    HPAi CAB019273.
    MIMi 603399. gene.
    neXtProti NX_O76076.
    PharmGKBi PA37373.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82184.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi O76076.
    OMAi SNQNRFC.
    OrthoDBi EOG77T15K.
    PhylomeDBi O76076.
    TreeFami TF326070.

    Enzyme and pathway databases

    SignaLinki O76076.

    Miscellaneous databases

    GeneWikii WNT1-inducible-signaling_pathway_protein_2.
    GenomeRNAii 8839.
    NextBioi 33180.
    PROi O76076.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O76076.
    Bgeei O76076.
    CleanExi HS_WISP2.
    Genevestigatori O76076.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions."
      Kumar S., Hand A.T., Connor J.R., Dodds R.A., Ryan P.J., Trill J.J., Fisher S.M., Nuttall M.E., Lipshutz D.B., Zou C., Hwang S.M., Votta B.J., James I.E., Rieman D.J., Gowen M., Lee J.C.
      J. Biol. Chem. 274:17123-17131(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "CT58, a new member of the connective tissue growth factor family, interacts with the breast cancer associated mucin MUC1."
      Rowles J., Gendler S.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
      Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J., Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L., Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J., Gurney A.L., Botstein D., Levine A.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    6. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Lung and Ovary.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38.

    Entry informationi

    Entry nameiWISP2_HUMAN
    AccessioniPrimary (citable) accession number: O76076
    Secondary accession number(s): B2R9N4, E1P612, Q6PEG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3