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Protein

WNT1-inducible-signaling pathway protein 2

Gene

WISP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • regulation of cell growth Source: InterPro
  • signal transduction Source: ProtInc

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

SignaLinkiO76076.

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
Connective tissue growth factor-like protein
Short name:
CTGF-L
Connective tissue growth factor-related protein 58
Gene namesi
Name:WISP2
Synonyms:CCN5, CT58, CTGFL
ORF Names:UNQ228/PRO261
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:12770. WISP2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8839.
OpenTargetsiENSG00000064205.
PharmGKBiPA37373.

Polymorphism and mutation databases

BioMutaiWISP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001440924 – 250WNT1-inducible-signaling pathway protein 2Add BLAST227

Proteomic databases

PaxDbiO76076.
PeptideAtlasiO76076.
PRIDEiO76076.

Expressioni

Tissue specificityi

Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.

Gene expression databases

BgeeiENSG00000064205.
CleanExiHS_WISP2.
GenevisibleiO76076. HS.

Organism-specific databases

HPAiCAB019273.

Interactioni

Protein-protein interaction databases

BioGridi114366. 8 interactors.
IntActiO76076. 4 interactors.
STRINGi9606.ENSP00000190983.

Structurei

3D structure databases

ProteinModelPortaliO76076.
SMRiO76076.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST71
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini194 – 238TSP type-1PROSITE-ProRule annotationAdd BLAST45

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWPW. Eukaryota.
ENOG410YSW1. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO76076.
OMAiLCVATQV.
OrthoDBiEOG091G0SQP.
PhylomeDBiO76076.
TreeFamiTF326070.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76076-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGTPKTHLL AFSLLCLLSK VRTQLCPTPC TCPWPPPRCP LGVPLVLDGC
60 70 80 90 100
GCCRVCARRL GEPCDQLHVC DASQGLVCQP GAGPGGRGAL CLLAEDDSSC
110 120 130 140 150
EVNGRLYREG ETFQPHCSIR CRCEDGGFTC VPLCSEDVRL PSWDCPHPRR
160 170 180 190 200
VEVLGKCCPE WVCGQGGGLG TQPLPAQGPQ FSGLVSSLPP GVPCPEWSTA
210 220 230 240 250
WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF
Length:250
Mass (Da):26,825
Last modified:November 1, 1998 - v1
Checksum:iC499837EF42FEEAC
GO
Isoform 2 (identifier: O76076-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-218: LAEDDSSCEV...GLGMATRVSN → CKQDPSFLAL...AWVHHAEHQY
     219-250: Missing.

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):22,577
Checksum:i2A8A79681111542B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04956659R → Q. Corresponds to variant dbSNP:rs33932543Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05629893 – 218LAEDD…TRVSN → CKQDPSFLALSLPCPLVSPA QNGARPGDPARPPVGWAWPP GCPTRTASADWRPSAACACP GPAHPPGVAVHKTVPSRAGL GMGTRCPPSPAGGPVPGPWA DGRWSVPRPLAAGNTLAWVH HAEHQY in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_056299219 – 250Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083500 mRNA. Translation: AAC70350.1.
AF074604 mRNA. Translation: AAC26794.1.
AF100780 mRNA. Translation: AAC96322.1.
AY358915 mRNA. Translation: AAQ89274.1.
AK313853 mRNA. Translation: BAG36581.1.
AL139352 Genomic DNA. Translation: CAB94788.1.
CH471077 Genomic DNA. Translation: EAW75902.1.
CH471077 Genomic DNA. Translation: EAW75903.1.
BC017782 mRNA. Translation: AAH17782.1.
BC058074 mRNA. Translation: AAH58074.1.
BC064379 mRNA. Translation: AAH64379.1.
CCDSiCCDS13336.1. [O76076-1]
CCDS82619.1. [O76076-2]
RefSeqiNP_001310298.1. NM_001323369.1. [O76076-2]
NP_001310299.1. NM_001323370.1. [O76076-1]
NP_003872.1. NM_003881.3. [O76076-1]
UniGeneiHs.592145.

Genome annotation databases

EnsembliENST00000190983; ENSP00000190983; ENSG00000064205. [O76076-1]
ENST00000372865; ENSP00000361956; ENSG00000064205. [O76076-2]
ENST00000372868; ENSP00000361959; ENSG00000064205. [O76076-1]
GeneIDi8839.
KEGGihsa:8839.
UCSCiuc002xmp.4. human. [O76076-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083500 mRNA. Translation: AAC70350.1.
AF074604 mRNA. Translation: AAC26794.1.
AF100780 mRNA. Translation: AAC96322.1.
AY358915 mRNA. Translation: AAQ89274.1.
AK313853 mRNA. Translation: BAG36581.1.
AL139352 Genomic DNA. Translation: CAB94788.1.
CH471077 Genomic DNA. Translation: EAW75902.1.
CH471077 Genomic DNA. Translation: EAW75903.1.
BC017782 mRNA. Translation: AAH17782.1.
BC058074 mRNA. Translation: AAH58074.1.
BC064379 mRNA. Translation: AAH64379.1.
CCDSiCCDS13336.1. [O76076-1]
CCDS82619.1. [O76076-2]
RefSeqiNP_001310298.1. NM_001323369.1. [O76076-2]
NP_001310299.1. NM_001323370.1. [O76076-1]
NP_003872.1. NM_003881.3. [O76076-1]
UniGeneiHs.592145.

3D structure databases

ProteinModelPortaliO76076.
SMRiO76076.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114366. 8 interactors.
IntActiO76076. 4 interactors.
STRINGi9606.ENSP00000190983.

Polymorphism and mutation databases

BioMutaiWISP2.

Proteomic databases

PaxDbiO76076.
PeptideAtlasiO76076.
PRIDEiO76076.

Protocols and materials databases

DNASUi8839.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000190983; ENSP00000190983; ENSG00000064205. [O76076-1]
ENST00000372865; ENSP00000361956; ENSG00000064205. [O76076-2]
ENST00000372868; ENSP00000361959; ENSG00000064205. [O76076-1]
GeneIDi8839.
KEGGihsa:8839.
UCSCiuc002xmp.4. human. [O76076-1]

Organism-specific databases

CTDi8839.
DisGeNETi8839.
GeneCardsiWISP2.
HGNCiHGNC:12770. WISP2.
HPAiCAB019273.
MIMi603399. gene.
neXtProtiNX_O76076.
OpenTargetsiENSG00000064205.
PharmGKBiPA37373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWPW. Eukaryota.
ENOG410YSW1. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiO76076.
OMAiLCVATQV.
OrthoDBiEOG091G0SQP.
PhylomeDBiO76076.
TreeFamiTF326070.

Enzyme and pathway databases

SignaLinkiO76076.

Miscellaneous databases

GeneWikiiWNT1-inducible-signaling_pathway_protein_2.
GenomeRNAii8839.
PROiO76076.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064205.
CleanExiHS_WISP2.
GenevisibleiO76076. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWISP2_HUMAN
AccessioniPrimary (citable) accession number: O76076
Secondary accession number(s): B2R9N4, E1P612, Q6PEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1998
Last modified: March 15, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.