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Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

CIAO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.UniRule annotation2 Publications

GO - Biological processi

  • chromosome segregation Source: UniProtKB-KW
  • iron-sulfur cluster assembly Source: UniProtKB
  • positive regulation of cell proliferation Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144021-MONOMER.
ReactomeiR-HSA-2564830. Cytosolic iron-sulfur cluster assembly.
SignaLinkiO76071.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:CIAO1UniRule annotation
Synonyms:WDR39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14280. CIAO1.

Subcellular locationi

GO - Cellular componenti

  • CIA complex Source: UniProtKB
  • MMXD complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9391.
OpenTargetsiENSG00000144021.
PharmGKBiPA162382269.

Polymorphism and mutation databases

BioMutaiCIAO1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513891 – 339Probable cytosolic iron-sulfur protein assembly protein CIAO1Add BLAST339

Proteomic databases

EPDiO76071.
MaxQBiO76071.
PaxDbiO76071.
PeptideAtlasiO76071.
PRIDEiO76071.
TopDownProteomicsiO76071.

PTM databases

iPTMnetiO76071.
PhosphoSitePlusiO76071.

Expressioni

Gene expression databases

BgeeiENSG00000144021.
CleanExiHS_CIAO1.
GenevisibleiO76071. HS.

Organism-specific databases

HPAiHPA017882.

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.UniRule annotation5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM96AQ9H5X110EBI-725145,EBI-752069
FAM96BQ9Y3D011EBI-725145,EBI-744045
MEOX1P502213EBI-725145,EBI-2864512
MMS19Q96T76-85EBI-725145,EBI-10190644
SF1Q156373EBI-725145,EBI-744603

Protein-protein interaction databases

BioGridi114791. 80 interactors.
IntActiO76071. 14 interactors.
MINTiMINT-1416717.
STRINGi9606.ENSP00000418287.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi19 – 24Combined sources6
Beta strandi31 – 35Combined sources5
Beta strandi40 – 46Combined sources7
Beta strandi49 – 56Combined sources8
Beta strandi64 – 69Combined sources6
Beta strandi73 – 80Combined sources8
Beta strandi85 – 90Combined sources6
Beta strandi95 – 101Combined sources7
Beta strandi108 – 113Combined sources6
Beta strandi117 – 124Combined sources8
Beta strandi129 – 134Combined sources6
Beta strandi140 – 146Combined sources7
Beta strandi153 – 158Combined sources6
Beta strandi160 – 163Combined sources4
Beta strandi165 – 169Combined sources5
Beta strandi174 – 180Combined sources7
Beta strandi183 – 190Combined sources8
Beta strandi197 – 202Combined sources6
Beta strandi206 – 213Combined sources8
Beta strandi218 – 224Combined sources7
Beta strandi240 – 247Combined sources8
Beta strandi255 – 260Combined sources6
Turni262 – 264Combined sources3
Beta strandi267 – 271Combined sources5
Beta strandi276 – 281Combined sources6
Beta strandi292 – 298Combined sources7
Beta strandi301 – 304Combined sources4
Beta strandi306 – 311Combined sources6
Beta strandi313 – 315Combined sources3
Beta strandi318 – 323Combined sources6
Beta strandi328 – 333Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FM0X-ray1.70A1-339[»]
ProteinModelPortaliO76071.
SMRiO76071.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76071.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 53WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati103 – 142WD 3Add BLAST40
Repeati148 – 187WD 4Add BLAST40
Repeati192 – 231WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati301 – 339WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00860000133757.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiO76071.
OMAiWEVAGDD.
OrthoDBiEOG091G0AAM.
PhylomeDBiO76071.
TreeFamiTF318181.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1. 1 hit.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYREE EDDWVCCATL EGHESTVWSL
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCICTLSGF
260 270 280 290 300
HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ
310 320 330
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL
Length:339
Mass (Da):37,840
Last modified:November 1, 1998 - v1
Checksum:i63A8D8257A204FC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243C → G in BAD96977 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63810 mRNA. Translation: AAC24948.1.
EF011618 mRNA. Translation: ABK41108.1.
AC004020 Genomic DNA. Translation: AAC23493.1.
CR456802 mRNA. Translation: CAG33083.1.
AK223257 mRNA. Translation: BAD96977.1.
BC001395 mRNA. Translation: AAH01395.1.
BC032812 mRNA. Translation: AAH32812.1.
CCDSiCCDS2019.1.
RefSeqiNP_004795.1. NM_004804.2.
UniGeneiHs.12109.

Genome annotation databases

EnsembliENST00000488633; ENSP00000418287; ENSG00000144021.
GeneIDi9391.
KEGGihsa:9391.
UCSCiuc002svs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63810 mRNA. Translation: AAC24948.1.
EF011618 mRNA. Translation: ABK41108.1.
AC004020 Genomic DNA. Translation: AAC23493.1.
CR456802 mRNA. Translation: CAG33083.1.
AK223257 mRNA. Translation: BAD96977.1.
BC001395 mRNA. Translation: AAH01395.1.
BC032812 mRNA. Translation: AAH32812.1.
CCDSiCCDS2019.1.
RefSeqiNP_004795.1. NM_004804.2.
UniGeneiHs.12109.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FM0X-ray1.70A1-339[»]
ProteinModelPortaliO76071.
SMRiO76071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114791. 80 interactors.
IntActiO76071. 14 interactors.
MINTiMINT-1416717.
STRINGi9606.ENSP00000418287.

PTM databases

iPTMnetiO76071.
PhosphoSitePlusiO76071.

Polymorphism and mutation databases

BioMutaiCIAO1.

Proteomic databases

EPDiO76071.
MaxQBiO76071.
PaxDbiO76071.
PeptideAtlasiO76071.
PRIDEiO76071.
TopDownProteomicsiO76071.

Protocols and materials databases

DNASUi9391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000488633; ENSP00000418287; ENSG00000144021.
GeneIDi9391.
KEGGihsa:9391.
UCSCiuc002svs.4. human.

Organism-specific databases

CTDi9391.
DisGeNETi9391.
GeneCardsiCIAO1.
HGNCiHGNC:14280. CIAO1.
HPAiHPA017882.
MIMi604333. gene.
neXtProtiNX_O76071.
OpenTargetsiENSG00000144021.
PharmGKBiPA162382269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0645. Eukaryota.
ENOG410XRMA. LUCA.
GeneTreeiENSGT00860000133757.
HOGENOMiHOG000208901.
HOVERGENiHBG056532.
InParanoidiO76071.
OMAiWEVAGDD.
OrthoDBiEOG091G0AAM.
PhylomeDBiO76071.
TreeFamiTF318181.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144021-MONOMER.
ReactomeiR-HSA-2564830. Cytosolic iron-sulfur cluster assembly.
SignaLinkiO76071.

Miscellaneous databases

ChiTaRSiCIAO1. human.
EvolutionaryTraceiO76071.
GeneWikiiCIAO1.
GenomeRNAii9391.
PROiO76071.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144021.
CleanExiHS_CIAO1.
GenevisibleiO76071. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03037. ciao1. 1 hit.
InterProiIPR028608. CIAO1/Cia1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIAO1_HUMAN
AccessioniPrimary (citable) accession number: O76071
Secondary accession number(s): A0MNN9, Q53FM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Ciao' means 'bridge' in Chinese.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.