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Protein

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Gene

CIAO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.UniRule annotation2 Publications

Miscellaneous

'Ciao' means 'bridge' in Chinese.

GO - Biological processi

  • chromosome segregation Source: UniProtKB-KW
  • iron-sulfur cluster assembly Source: UniProtKB
  • positive regulation of cell proliferation Source: ProtInc
  • regulation of transcription by RNA polymerase II Source: ProtInc

Keywordsi

Biological processChromosome partition

Enzyme and pathway databases

ReactomeiR-HSA-2564830 Cytosolic iron-sulfur cluster assembly
SignaLinkiO76071

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosolic iron-sulfur protein assembly protein CIAO1UniRule annotation
Alternative name(s):
WD repeat-containing protein 39UniRule annotation
Gene namesi
Name:CIAO1UniRule annotation
Synonyms:WDR39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144021.2
HGNCiHGNC:14280 CIAO1
MIMi604333 gene
neXtProtiNX_O76071

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9391
OpenTargetsiENSG00000144021
PharmGKBiPA162382269

Polymorphism and mutation databases

BioMutaiCIAO1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513891 – 339Probable cytosolic iron-sulfur protein assembly protein CIAO1Add BLAST339

Proteomic databases

EPDiO76071
MaxQBiO76071
PaxDbiO76071
PeptideAtlasiO76071
PRIDEiO76071
ProteomicsDBi50373
TopDownProteomicsiO76071

PTM databases

iPTMnetiO76071
PhosphoSitePlusiO76071

Expressioni

Gene expression databases

BgeeiENSG00000144021
CleanExiHS_CIAO1
GenevisibleiO76071 HS

Organism-specific databases

HPAiHPA017882

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.UniRule annotation5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114791, 85 interactors
IntActiO76071, 22 interactors
MINTiO76071
STRINGi9606.ENSP00000418287

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi19 – 24Combined sources6
Beta strandi31 – 35Combined sources5
Beta strandi40 – 46Combined sources7
Beta strandi49 – 56Combined sources8
Beta strandi64 – 69Combined sources6
Beta strandi73 – 80Combined sources8
Beta strandi85 – 90Combined sources6
Beta strandi95 – 101Combined sources7
Beta strandi108 – 113Combined sources6
Beta strandi117 – 124Combined sources8
Beta strandi129 – 134Combined sources6
Beta strandi140 – 146Combined sources7
Beta strandi153 – 158Combined sources6
Beta strandi160 – 163Combined sources4
Beta strandi165 – 169Combined sources5
Beta strandi174 – 180Combined sources7
Beta strandi183 – 190Combined sources8
Beta strandi197 – 202Combined sources6
Beta strandi206 – 213Combined sources8
Beta strandi218 – 224Combined sources7
Beta strandi240 – 247Combined sources8
Beta strandi255 – 260Combined sources6
Turni262 – 264Combined sources3
Beta strandi267 – 271Combined sources5
Beta strandi276 – 281Combined sources6
Beta strandi292 – 298Combined sources7
Beta strandi301 – 304Combined sources4
Beta strandi306 – 311Combined sources6
Beta strandi313 – 315Combined sources3
Beta strandi318 – 323Combined sources6
Beta strandi328 – 333Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FM0X-ray1.70A1-339[»]
ProteinModelPortaliO76071
SMRiO76071
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76071

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 53WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati103 – 142WD 3Add BLAST40
Repeati148 – 187WD 4Add BLAST40
Repeati192 – 231WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati301 – 339WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat CIA1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0645 Eukaryota
ENOG410XRMA LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000208901
HOVERGENiHBG056532
InParanoidiO76071
OMAiVWKCVCT
OrthoDBiEOG091G0AAM
PhylomeDBiO76071
TreeFamiTF318181

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03037 ciao1, 1 hit
InterProiView protein in InterPro
IPR028608 CIAO1/Cia1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19920 PTHR19920, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O76071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW
60 70 80 90 100
ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT
110 120 130 140 150
LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT
160 170 180 190 200
QDVKHVVWHP SQELLASASY DDTVKLYREE EDDWVCCATL EGHESTVWSL
210 220 230 240 250
AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCICTLSGF
260 270 280 290 300
HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ
310 320 330
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL
Length:339
Mass (Da):37,840
Last modified:November 1, 1998 - v1
Checksum:i63A8D8257A204FC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243C → G in BAD96977 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63810 mRNA Translation: AAC24948.1
EF011618 mRNA Translation: ABK41108.1
AC004020 Genomic DNA Translation: AAC23493.1
CR456802 mRNA Translation: CAG33083.1
AK223257 mRNA Translation: BAD96977.1
BC001395 mRNA Translation: AAH01395.1
BC032812 mRNA Translation: AAH32812.1
CCDSiCCDS2019.1
RefSeqiNP_004795.1, NM_004804.2
UniGeneiHs.12109

Genome annotation databases

EnsembliENST00000488633; ENSP00000418287; ENSG00000144021
GeneIDi9391
KEGGihsa:9391
UCSCiuc002svs.4 human

Similar proteinsi

Entry informationi

Entry nameiCIAO1_HUMAN
AccessioniPrimary (citable) accession number: O76071
Secondary accession number(s): A0MNN9, Q53FM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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